Association between vitamin D levels and frequency of disease exacerbations and hospitalizations in patients with COPD
| dc.contributor.author | Bulut, Sertan | |
| dc.contributor.author | Karamanlı, Harun | |
| dc.contributor.author | Şahin, Mustafa Engin | |
| dc.contributor.author | Çelik, Deniz | |
| dc.contributor.author | Biber, Çiğdem | |
| dc.date.accessioned | 2023-05-23T07:20:12Z | |
| dc.date.available | 2023-05-23T07:20:12Z | |
| dc.date.issued | 2022 | |
| dc.department | ALKÜ, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | |
| dc.description.abstract | Introduction: Chronic obstructive pulmonary disease (COPD) is a debilitating disorder that restricts the physical activity of patients who are deprived of sunlight, which is a source of vitamin D. The purpose of this study was to assess the relationship between vitamin D and the frequency of exacerbation and hospitalization among patients with COPD. Material and Method: In the main analysis, 303 patients with COPD (stage GOLD A to D) were included in a retrospective cohort study in Turkey. Serum levels of vitamin D (25-hydroxyvitamin D) were measured in 303 patients with COPD and were associated with pulmonary function, AECOPD frequency and hospitalization in the previous year. Results: For COPD patients, the mean reference level of 25 hydroxyvitamin D in serum was 12.5 ng/dL. In comparison to patients with a serious 25-hydroxyvitamin D deficiency (< 10 ng/dL, n=119 [39,3%]), patients with a moderate deficiency (10-19.99 ng/dL, n=100 [33%]), inadequate levels (20-29.99 ng/dL, n=49 [16,2%]) presented a different risk of exacerbation (incidence rate ratio, 2.3 [95% CI, 1.9-2.6], 1.6 [95% CI, 1.2-2.0], and 0.8 [95% CI, 0.3-1.2] respectively). In patients with desirable levels (> 30 ng/dL, n=34 [11,2%]), the risk was lower but not significant (incidence ratio, 0.7 [95% CI, 0.2-1.2]. In COPD patients, 25-hydroxyvitamin D rates are low correlated with 1-s forced expiratory volume (FEV1) (r=0.187, p=0.0013). Conclusion: 25-hydroxyvitamin D deficiency is a frequent occurrence in COPD and is correlated with the frequency of exacerbation and hospitalization in COPD patients. | |
| dc.identifier.doi | 10.32322/jhsm.1050722 | |
| dc.identifier.endpage | 477 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 471 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12868/2136 | |
| dc.identifier.volume | 5 | en_US |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.relation.ispartof | Journal of Health Sciences and Medicine | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | 25-hydroxyvitamin D | |
| dc.subject | COPD | |
| dc.subject | COPD exacerbation | |
| dc.title | Association between vitamin D levels and frequency of disease exacerbations and hospitalizations in patients with COPD | |
| dc.type | Article |
