Caffeic Acid Based Polyurethane Membrane Modified Screen-Printed Electrodes and Their Application for the Simultaneous Determination of Melatonin and Serotonin

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dc.contributor.authorErel, Ensar
dc.contributor.authorTunc, Merve Goksin Karaaslan
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2026-01-24T12:31:24Z
dc.date.available2026-01-24T12:31:24Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractCaffeic acid (CA) based polyurethane (PU) films were synthesized and characterized for the simultaneous determination of melatonin (MT) and serotonin (5-HT). The CA based PUs were synthesized using a polyol mixture of 4,4'-diisocyanodiphenylmethane (MPI), polyethylene glycol-200 (PEG), and CA. The PEG-CA monomer units in the polyol were varied in molar ratios of 99:1, 97:3, 95:5, and 90:10. The synthesized PUs were characterized by FTIR spectroscopy and thermal analysis. These CA based PU films were coated onto screen-printed carbon electrodes (SPCEs) with varying thicknesses and used for the simultaneous determination of MT and 5-HT. Electrochemical responses of MT and 5-HT were evaluated using differential pulse voltammetry. The limit of detection and correlation coefficient for MT were 280 mu M and 0.9797, respectively, while for 5-HT, the detection was 150 mu M with a correlation coefficient of 0.9690. The precision, expressed as the relative standard deviation was 2.633% for MT and 4.668% for 5-HT. These findings suggest that CA based PU-modified electrodes hold potential in medical and biomedical applications.
dc.description.sponsorshipInonu University Scientific Research Projects unit [BAP-2016-33]
dc.description.sponsorshipWe would like to thank Inonu University Scientific Research Projects unit for supporting this study by project number BAP-2016-33.
dc.identifier.doi10.1080/00032719.2024.2420907
dc.identifier.endpage2568
dc.identifier.issn0003-2719
dc.identifier.issn1532-236X
dc.identifier.issue15
dc.identifier.startpage2551
dc.identifier.urihttps://doi.org/10.1080/00032719.2024.2420907
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5844
dc.identifier.volume58
dc.identifier.wosWOS:001347009900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofAnalytical Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectCaffeic acid
dc.subjectdifferential pulse voltammetry (DPV)
dc.subjectelectrochemical analysis
dc.subjectmelatonin
dc.subjectpolyurethane
dc.subjectserotonin
dc.subjectvoltammetric sensor
dc.titleCaffeic Acid Based Polyurethane Membrane Modified Screen-Printed Electrodes and Their Application for the Simultaneous Determination of Melatonin and Serotonin
dc.typeArticle

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