Serum ZO-1 and occludin levels in bipolar disorder patients

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dc.contributor.authorAydoğan Avşar, Pınar
dc.contributor.authorAkkuş, Merve
dc.date.accessioned2026-01-24T12:20:44Z
dc.date.available2026-01-24T12:20:44Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBipolar disorder is a mental illness with a complex and multidimensional etiology. The blood-brain barrier (BBB) is a semi-permeable barrier between the central nervous system (CNS) and peripheral circulation that protects the CNS from external threats. The healthy functioning of the BBB is ensured by tight junctions (TJs) between cells. This research aims to investigate the serum levels of TJ proteins occludin and zonula occludens-1 protein (ZO-1) in bipolar disorder to elucidate etiopathogenesis. This study included 40 BD patients (20 manic episodes, 20 euthymic episodes) and 40 healthy controls. Serum occludin and ZO-1 values were obtained and compared between the two groups. The serum occludin and ZO-1 levels were significantly higher in the bipolar disorder patients. The analysis of covariance (ANCOVA) revealed a significant main effect of groups in the serum occludin and ZO-1 levels and an effect that was independent of age, gender, BMI, and smoking.BBB disruption and neuroinflammation may play a role in bipolar disorder etiopathogenesis. Occludin and ZO-1 may serve as potential biomarkers for BBB leakage in bipolar disorder. Further research may lead to additional pharmacological therapies targeting BBB for drug-resistant bipolar disorder patients. © Springer-Verlag GmbH Germany, part of Springer Nature 2025.
dc.identifier.doi10.1007/s00406-025-02097-7
dc.identifier.issn0940-1334
dc.identifier.scopus2-s2.0-105014886793
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00406-025-02097-7
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4552
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260121
dc.subjectBBB
dc.subjectBipolar disorder
dc.subjectBrain-blood-barrier
dc.subjectOccludin
dc.subjectTight junction proteins
dc.subjectZO-1
dc.titleSerum ZO-1 and occludin levels in bipolar disorder patients
dc.typeArticle

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