Yazar "Sözen, Mehmet Enes" seçeneğine göre listele

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    Farklı Konsantrasyonlardaki Monosodyum Glutamatın Koryoallantoik Membran Modelinde Anti-Anjiyojenik ve Oksidan Etkileri
    (Muğla Sıtkı Koçman Üniversitesi, 2023) Sözen, Mehmet Enes; Savaş, Hasan Basri; Akkaya, Özgür; Karahan, Oğuz
    Monosodyum glutamat (MSG), lezzet artırıcı bir gıda katkı maddesidir. İşlenmiş gıda tüketimindeki yükselişe bağlı olarak MSG maruziyeti her geçen gün artmaktadır. MSG maruziyeti çeşitli doku ve organlara zarar vermektedir. Bu çalışmanın amacı, MSG'nin anjiyogenez ve oksidan-antioksidan dengesi üzerindeki etkilerini araştırmaktır. Üç farklı konsantrasyonda MSG (10-4 M, 10-5 M ve 10-6 M), kontrol ve bevasizumab (10-6 M) hazırlanıp, embriyoların korioallantoik membranına (CAM) yerleştirildi. Deneyden önce ve sonra tavuk yumurtalarından sıvı alındı. Yumurta kabuğu üzerinde açılan pencereden anjiyogenez araştırıldı. Kontrol ve 10-6 M MSG grubunda (ortalama skor: 0.3) anjiyogenez normal bulundu. Anti-anjiyojenik etkilerin, 10-5 M MSG grubunda (ortalama puan: 0.5) ve 10-4 M MSG grubunda (ortalama puan: 0.7) orta düzeyde ve bevasizumab grubunda (ortalama puan: 1.1) güçlü olduğu tespit edildi. Sonuçlarımıza göre MSG daha yüksek dozlarda antianjiyogenik özellikler göstermektedir. Araştırmamızın sonuçlarına göre MSG'nin CAM modelinde anjiyogenezi doza bağımlı bir şekilde inhibe ettiği ve oksidan-antioksidan dengesini bozarak oksidatif hasarda artışa neden olabileceği görülmektedir. MSG'nin CAM modelinde anjiyogenez ve oksidan-antioksidan denge üzerindeki etkilerine ilişkin literatürde daha önce yapılmış bir çalışma tespit edilemediği için araştırma sonuçlarımızın literatürdeki önemli bir eksikliği gidereceğini düşünmekteyiz.
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    Öğe
    Medical Tourism in Alanya from the Perspective of Sectoral Stakeholders
    (Onur OĞUZ, 2023) Kuzkaya, Ümit; Işık, Fikret; Sözen, Mehmet Enes
    This study aims to evaluate Alanya's medical tourism from the perspective of sectoral stakeholders. The study was conducted in accordance with qualitative research methods and phenomenological design. In the study, the participants were determined by maximum diversity sampling from purposive sampling methods. The study group of the research consists of 11 managers working in Alanya. A semi-structured interview form was used to create the primary data set in the study. Audio recordings of the interviews were taken with the permission of the participants. Within the scope of the research, the audio recordings of the interviews were digitized using MS Word program as raw data without any screening. Each transcript was analyzed with a line-by-line analysis approach and the interview data were interpreted with inductive descriptive analysis method. As a result of the analysis of the data, the findings were grouped under five main themes: Evaluations on the country environment in terms of medical tourism, Evaluations on Tourism Destination, Evaluations on Medical Tourism Costs, Evaluations on Facilities and Services, General evaluations on Medical Tourism. As a result of the research, it was determined that Alanya is one of the important medical tourism destinations, but its potential is not sufficiently utilized. In order for Alanya to realize its potential, it is recommended that medical tourism should be implemented with a holistic approach and unregistered activities should be prevented from disrupting the competitive environment.
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    Öğe
    The effect of tartrazine on angiogenesis and oxidative stress in the chorioallantoic membrane model
    (Field Crops Central Research Institute, 2025) Savaş, Hasan Basri; Sözen, Mehmet Enes; Dinc, Elina
    Tartrazine is commonly preferred as a coloring agent in non-alcoholic beverages, fruit juices, jellies, cereals, and soups. This study aims to investigate the effects of tartrazine exposure on anti-angiogenesis and the oxidant-antioxidant balance. Three different tartrazine dose, a bevacizumab, and an empty pellet used to evaluate anti-angiogenic effects on the chorioallantoic membrane (CAM) model. Fluid samples were collected for measurements of total antioxidant capacity (TAC) and total oxidant status (TOS), from which the oxidative stress index (OSI) was calculated. The control group and 10-6 M tartrazine group had no anti-angiogenic impact, but the bevacizumab group had a strong anti-angiogenic effect. Furthermore, the 10-4 M and 10-5 M tartrazine groups had a weak anti-angiogenic effect. The levels of TOS increase with tartrazine consumption. TAC values were highest in the 10-6 M tartrazine group and lowest in the 10-5 M tartrazine group. Moreover, OSI values have increased in the 10-4 M tartrazine group, 10-5 M tartrazine group, and 10-6 M tartrazine group compared to control group. This study demonstrates that tartrazine exposure leads to dose-dependent increases in oxidative stress and, in parallel, exhibits dose-dependent anti-angiogenic effects. For this reason, it is recommended to be careful when consuming products containing tartrazine. © 2025, Field Crops Central Research Institute. All rights reserved.