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    A Rare Complication of Simple Hepatic Cyst: Spontaneous Rupture, Case Report and Literature Review
    (2020) Güler, Yılmaz; Sengul, Serkan; Çalış, Hasan; Ozen, Ozkan; Karabulut, Zülfikar
    Simple hepatic cysts are usually asymptomatic; most of them are found incidentally, and complications, such as rupture, bleeding, infection and obstructive jaundice, are rare. Intracystic hemorrhage is seen in 2-5% cases, but cyst rupture is an uncommon complication of hepatic cysts. A 70-year-old man without trauma history was admitted to our hospital’s emergency department with severe abdominal pain. Urgent laparotomy and surgical excision of the cyst were performed, revealing a ruptured cyst approximately 10x15 cm in size over the leftliver lobe and a rupture hole approximately 1.5 cm in size over the cystic wall. The postoperative period was uneventful, and the patient was discharged six days after the operation. Spontaneous rupture is an extremely rare complication of simple hepatic cysts. Treatment for symptomatic hepatic cysts includes percutaneous aspiration and surgery. Surgical intervention, especially laparotomy, was preferred in most cases.
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    Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?
    (Pergamon-Elsevier Science Ltd, 2023) Avnioglu, Seda; Sahin, Caner; Cankaya, Seyda; Ozen, Ozkan; Dikici, Rumeysa; Yilmaz, Halil; Velioglu, Halil Aziz
    Purpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.
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    Morphometric evaluation of cerebellar lobules in individuals with unilateral vertebral artery hypoplasia
    (Springer France, 2023) Ozen, Ozkan; Yuksel, Yavuz; Torun, Ebru; Ergun, Tarkan
    Purpose Vertebral arteries (VAs) provide blood circulation to the posterior fossa in general and are the main blood supply of the posterior fossa structures of the brain. Our aim in this study is to analyze the segmental volumetric values of cerebellar structures with the voxel-based volumetric analysis system in individuals with unilateral vertebral artery hypoplasia. Methods In this retrospective study, segmental volumetric values/percentile ratios of cerebellar lobules were calculated using 3D fast spoiled gradient recall acquisition in steady-state (3D T1 FSPGR) MRI sequence images of the brain in individuals with unilateral vertebral artery hypoplasia (VAH) and in those without bilateral VAH and any symptoms of vertebrobasilar insufficiency as the control group was evaluated in volBrain. Results The VAH group consisted of 50 (19 males/31 females) and the control group had 50 (21 males/29 females) individuals. The cerebellar lobule III, IV, VIIIA and X total volumes and the cerebellar lobule I-II, III, IV, VIIIA and X gray matter volumes were lower in the hypoplastic side than the non-hypoplastic cases and also than the contralateral side of the hypoplastic cases in the VAH group. In addition, it was found that that lobules IV and V had lower cortical thickness and lobules I-II had a higher coverage rate in the intracranial cavity in the hypoplastic side than the non-hypoplastic cases and also than the contralateral side of the hypoplastic cases (p < 0.05). Conclusion In this study, it was found that cerebellar lobule III, IV, VIIIA, X total volumes and cerebellar lobule I-II, III, IV, VIIIA, X gray matter volumes in addition to lobule IV, V cortical thicknesses were low in individuals with unilateral VAH. Being aware of these variations and taking them into account during future volumetric studies on the cerebellum are very important.
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    Morphometric evaluation of cerebral and cerebellar structures in long-term unilateral sensorineural hearing loss
    (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2025) Kubat, Gozde Orhan; Ozen, Ozkan; Colak, Emre
    Objective: Structural changes in the brain have been identified in patients with hearing loss. However, the effect of long-term Unilateral Sensorineural Hearing Loss (USNHL) on cerebral and cerebellar morphology is not fully understood. Methods: In this study, Magnetic Resonance Imaging (MRI) of 12 long-term USNHL adults was compared with their Normal-Hearing (NH) side using Voxel-Based Morphometry (VBM). The USNHL group was also compared to a control group of 12 hearing-healthy individuals. Volume and cortical thickness changes in cerebral and cerebellar structures, possibly related to hearing loss severity and duration, were assessed using VBM. Results: The study found that, compared to the control group, USNHL patients had significantly higher measurements in the Frontal Operculum (FO) Gray Matter (GM) volume (cm3) (p = 0.024), Superior Temporal Gyrus (STG) thickness (p = 0.041), and cerebellum IX GM volume (cm3) (p = 0.025). No significant differences were observed between the intact and NH sides in the USNHL group (p > 0.05). Conclusion: Cerebral and cerebellar structures, which are essential for perceiving and interpreting sound, integrating information, and coordinating movement, may undergo morphological changes due to neuroadaptive mechanisms in long-term USNHL patients. Larger case series are needed to explore the clinical implications of these changes for diagnosis, treatment, and prognosis. Levels of evidence: Level 3.
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    When Should Definitive Surgery Be Performed After Sacrococcygeal Pilonidal Sinus Abscess Drainage
    (2023) Güler, Yılmaz; Sengul, Serkan; Çalış, Hasan; Karabulut, Zulfikar; Ozen, Ozkan
    Objective: The abscess development is one of the common clinical presentations of pilonidal sinus. Treatment in pilonidal sinus abscesses involves allowing secondary recovery following wide local excision with drainage, and excision procedures are performed after a few weeks and after the infection is completely cured. We aimed to investigate the effect of the time interval between the abscess drainage and definitive surgical treatment on the development of postoperative complications in patients who had pilonidal sinus abscess. Methods: The patients were divided into 2 groups according to the time interval from abscess drainage to sinus excision surgery: patients who under- went sinus excision 1 month after abscess drainage comprised group 1 and patients who underwent sinus excision 3 months after abscess drainage comprised group 2. Sinus excision and primary closure surgery were performed in patients in both groups. Results: In total, 44 patients (53.0%) underwent sinus excision group 1 and 39 patients (47.0%) underwent sinus excision group 2 after abscess drainage. Postoperative wound infection and wound dehiscence rates were significantly higher in group 1 patients than in group 2 patients (P < .05). Conclusion: We suggest that for reducing postoperative complications, it would be a better approach performing sinus excision after waiting for at least 3 months following drainage instead of performing excision right after recovery of infection or within a few weeks after the abscess drainage.