Yazar "Neselioglu, Salim" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Altered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications
    (Sbem-Soc Brasil Endocrinologia & Metabologia, 2025) Aslanoglu, Nuri; Keskek, Sakir Ozgur; Neselioglu, Salim; Eren, Funda
    Objective: To evaluate the effect of diabetes mellitus and its chronic complications on thiol/disulfide homeostasis. Methods: The study included 381 participants divided into six groups: healthy controls (Group 1; n = 91), patients with prediabetes (Group 2; n = 50), patients with diabetes mellitus without complications (Group 3; n = 70), patients with diabetic retinopathy (Group 4; n = 47), patients with diabetic nephropathy (Group 5; n = 70), and patients with diabetic foot (Group 6; n = 53). Thiol/disulfide homeostasis was determined by measuring the reduction reaction of oxidized thiols. Results: Native thiol levels were low in patients with diabetes mellitus complications (Group 4, 264.7 +/- 58.5 mu mol/L; Group 5, 246.6 +/- 67.5 mu mol/L; Group 6, 174.3 +/- 65.9 mu mol/L), as were total thiol levels. The highest and lowest disulfide levels were observed in Group 1(controls; 20.4 +/- 5.2 mu mol/L) and Group 6 (16.2 +/- 5.7 mu mol/L), respectively. The disulfide/native thiol ratio was increased in Groups 4, 5, and 6 compared with Groups 1, 2, and 3. Conclusion: The presence of diabetes mellitus complications substantially decreased native thiol, total thiol, and disulfide levels.
  • [ X ]
    Öğe
    Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome
    (Walter De Gruyter Gmbh, 2021) Kucuksayan, Ertan; Ozben, Serkan; Tuac, Selma Topaloglu; Koseoglu, Mesrure; Erel, Ozcan; Neselioglu, Salim; Ozben, Tomris
    Objectives: Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods: A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results: Plasma total (401 +/- 27 mu mol/L) and native thiol (354 +/- 30 mu mol/L) levels were significantly lower, but disulphide level (24 +/- 6 itmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 +/- 36, 424 +/- 37, 15 +/- 5 mu mol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRL SSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions: Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.