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    Altered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications
    (Sbem-Soc Brasil Endocrinologia & Metabologia, 2025) Aslanoglu, Nuri; Keskek, Sakir Ozgur; Neselioglu, Salim; Eren, Funda
    Objective: To evaluate the effect of diabetes mellitus and its chronic complications on thiol/disulfide homeostasis. Methods: The study included 381 participants divided into six groups: healthy controls (Group 1; n = 91), patients with prediabetes (Group 2; n = 50), patients with diabetes mellitus without complications (Group 3; n = 70), patients with diabetic retinopathy (Group 4; n = 47), patients with diabetic nephropathy (Group 5; n = 70), and patients with diabetic foot (Group 6; n = 53). Thiol/disulfide homeostasis was determined by measuring the reduction reaction of oxidized thiols. Results: Native thiol levels were low in patients with diabetes mellitus complications (Group 4, 264.7 +/- 58.5 mu mol/L; Group 5, 246.6 +/- 67.5 mu mol/L; Group 6, 174.3 +/- 65.9 mu mol/L), as were total thiol levels. The highest and lowest disulfide levels were observed in Group 1(controls; 20.4 +/- 5.2 mu mol/L) and Group 6 (16.2 +/- 5.7 mu mol/L), respectively. The disulfide/native thiol ratio was increased in Groups 4, 5, and 6 compared with Groups 1, 2, and 3. Conclusion: The presence of diabetes mellitus complications substantially decreased native thiol, total thiol, and disulfide levels.
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    Visceral Adiposity Index, Body Fat Index and Fat Mass In Patients with Chronic Renal Failure
    (Galenos Yayincilik, 2020) Kunt, Sema; Keskek, Sakir Ozgur
    Aim: The aim of this study was to investigate the level of visceral adiposity index (VAI), body fat index and fat mass in patients with chronic renal failure (CRF). Methods: A total of 231 subjects were enrolled, of which 83, 64 and 84 subjects were hemodialysis patients, peritoneal dialysis patients and healthy subjects, respectively. VAI, body fat index and body fat mass were calculated in all groups. The results were compared between the groups. MedCalc 18.2.1 software program was used for statistical analysis. Results: In this study, we found higher levels of body fat index and body fat mass in the healthy group (p=0.016 and p=0.03, respectively). VAI was higher in patients with CRF (p<0.001). Conclusion: Visceral adipose tissue is a metabolically active organ and it is an independent risk factor for metabolic alterations and development of cardiovascular diseases. High level of VAI can give an idea about cardiovascular diseases in patients with CRF.