Yazar "Karahan, Oğuz" seçeneğine göre listele
Listeleniyor 1 - 17 / 17
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute phase reactant proteins in Buerger's disease: Is it a systemic disease?(2022) Keramat, Shayan; Karahan, Oğuz; Patel, Malay; Fazeli, BahareAim: The aim of this study was evaluating acute phase reactant (APR) proteins including high sensitivity C-reactive protein (hsCRP), pentraxin 3 (PTX3), fibrinogen, complement C3, hepcidin, and albumin in patients suffering from Buerger's disease (BD) compared to controls. Methods: The APRs were evaluated in 92 cases of BD patients and 90 healthy age and sex matched controls of blood from Iran and Turkey. The diagnosis was done according to Shionoya's criteria. However, patients with age less than 40 were included, instead of those less than 50. The diagnosis was confirmed by angiography or CT angiography. The patients were categorized into active and quiescent phases of the disease according to clinical manifestation. Patients with rest pain, non-healing ulcer, and gangrene were categorized in the active phase of the disease and the patients with unchanged claudication for more than 6 months without trophic lesions or gangrene were categorized in the quiescent phase of the disease. Results: The serum level of PTX3, hsCRP, fibrinogen, C3, and hepcidin in BD was significantly higher than controls (p < 0.004). Also, albumin in the BD group was significantly lower than controls (p < 0.001). In patients that categorized in the active phase, fibrinogen, C3, and hsCRP were significantly higher and albumin was significantly lower compared to patients in the quiescent phase. No significant difference was found between the level of PTX3 and hepcidin in the patients in active and quiescent phases of the disease. Conclusion: The pattern of the level of APRs in BD seems more likely systemic inflammatory disorder than atherosclerosis obliterans. More clinical trials for evaluating the efficacy of anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, and corticosteroids as a part of management of BD are required. Also, according to low level of albumin in TAO, a protein rich diet might be beneficial for BD patients in the active phase of their disease.Öğe Analysis of routine blood markers for predicting amputation/re-amputation risk in diabetic foot(Wiley, 2020) Gülcü, Anıl; Etli, Mustafa; Karahan, Oğuz; Aslan, AhmetDiabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re-amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee-disarticulation, above-knee amputation) and re-amputations recorded and compared with routine blood parameters. Re-amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (P < 0.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re-amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re-amputation. The statistically optimal HbA1c cutoff point for diabetes was >= 7.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re-amputation possibility.Öğe Bilimsellik ve H-endeksi(Alanya Alaaddin Keykubat Üniversitesi, 2020) Karahan, Oğuz; Aslan, AhmetBilimsellik, bir akademisyenin veya bir bilim adamının literatüre bilimsel katkısını tanımlayan kapsamlı bir ifadedir. Bilimselliği saptamak için kabul edilen bazı belirleyiciler vardır. h-endeksi, katkıda bulunanların bilimsel seviyesinin tespiti için hali hazırda kullanılan göstergelerden biridir. Bu yazıda h-indeksi ve gerekliliğini açıklamaya odaklandık.Öğe Cilostazol induces angiogenesis and regulates oxidative stress in adose-dependent manner: A chorioallantoic membrane study(2021) Etli, Mutlu; Karahan, Oğuz; Akkaya, Özgür; Savaş, Hasan BasriBackground: In this study, we aimed to investigate the effects ofcilostazol on angiogenesis and oxidative stress using the chorioallantoicmembrane model. Methods: In this experimental study, the Ross 308 chick embryos wereused. The negative control group (n=10) received no intervention. Thepositive control group (n=10) consisted of eggs treated with epidermalgrowth factor for inducing angiogenesis. Three cilostazol groups weredesigned with 10-7 (n=10), 10-6 (n=10), and 10-5 (n=10) M concentrations.Each egg was punctured on the sixth day of incubation, and drugpellets were introduced to the positive control and drug groups at theprespecified doses. Vascular development was evaluated on the eighthday of application. The total oxidant status, total antioxidant capacity,and oxidative stress index levels were determined from albumen liquidsobtained with a syringe before and after drug application. Results: Lower oxidative stress index levels were obtained fromthe positive control and cilostazol groups compared to the negativecontrol albumens (p=0.001). The increments in vascular junctions andnewly developed vascular nodules were evaluated in drug-free anddrug-applied chorioallantoic membranes. The highest activity wasobtained in the 10-7 M concentration cilostazol group. An increasedangiogenic activity was detected in all drug groups in each concentrationcompared to the negative control group (p=0.001). Angiogenic activitywas similar in all the cilostazol-treated groups (p=0.43).Conclusion: Cilostazol has a positive stimulant effect on angiogenesisand it seems to suppress oxidative stress during embryonic growth.Cilostazol exerts these effects significantly and similarly at differentdoses.Öğe Evaluation of the predictive role of standard laboratory tests for disease severity in patients with deep venous thrombosis(2022) Etli, Mustafa; Karahan, Oğuz; Serhatlıoğlu, Faruk; Öntaş, HakanIntroduction: Deep venous thrombosis (DVT) can result in fatal outcomes if it is not timely diagnosed and sufficiently treated. Some laboratory markers were identified in previous reports for predicting the disease with low sensitivity or specificity. We aimed to evaluate the predictive value of serum albumin levels and compare them with conventional laboratory parameters. Material and methods: Fifty patients with acute lower-extremity DVT who has no previous history of malignancy or hematologic disorder were included in the study. The demographical variables and standard biomarkers of the DVT group were compared with the normal population (n:50). Thereafter patients were divided into two groups extensive DVT (thrombosis involves popliteal, femoral, and iliac veins together) and localized DVT (thrombosis involves popliteal vein and below) and biomarkers were compared in patient groups. Results: The demographical variables and white blood cell count (WBC) were found as similar between healthy groups and DVT groups. However, mean platelet volume (MPV), D-Dimer, neutrophil to lymphocyte ratio (NLR), and fibrinogen to albumin ratio (FAR) were found markedly higher in DVT patients. Moreover, statistically incremental FAR and NLR levels were detected (p < 0.05) in patients with extensive DVT (involved iliac and femoral veins). Conclusion: Serum NLR and FAR levels seem to be significant predictors for the extensive thrombotic event in patients with DVT.Öğe Farklı Konsantrasyonlardaki Monosodyum Glutamatın Koryoallantoik Membran Modelinde Anti-Anjiyojenik ve Oksidan Etkileri(Muğla Sıtkı Koçman Üniversitesi, 2023) Sözen, Mehmet Enes; Savaş, Hasan Basri; Akkaya, Özgür; Karahan, OğuzMonosodyum glutamat (MSG), lezzet artırıcı bir gıda katkı maddesidir. İşlenmiş gıda tüketimindeki yükselişe bağlı olarak MSG maruziyeti her geçen gün artmaktadır. MSG maruziyeti çeşitli doku ve organlara zarar vermektedir. Bu çalışmanın amacı, MSG'nin anjiyogenez ve oksidan-antioksidan dengesi üzerindeki etkilerini araştırmaktır. Üç farklı konsantrasyonda MSG (10-4 M, 10-5 M ve 10-6 M), kontrol ve bevasizumab (10-6 M) hazırlanıp, embriyoların korioallantoik membranına (CAM) yerleştirildi. Deneyden önce ve sonra tavuk yumurtalarından sıvı alındı. Yumurta kabuğu üzerinde açılan pencereden anjiyogenez araştırıldı. Kontrol ve 10-6 M MSG grubunda (ortalama skor: 0.3) anjiyogenez normal bulundu. Anti-anjiyojenik etkilerin, 10-5 M MSG grubunda (ortalama puan: 0.5) ve 10-4 M MSG grubunda (ortalama puan: 0.7) orta düzeyde ve bevasizumab grubunda (ortalama puan: 1.1) güçlü olduğu tespit edildi. Sonuçlarımıza göre MSG daha yüksek dozlarda antianjiyogenik özellikler göstermektedir. Araştırmamızın sonuçlarına göre MSG'nin CAM modelinde anjiyogenezi doza bağımlı bir şekilde inhibe ettiği ve oksidan-antioksidan dengesini bozarak oksidatif hasarda artışa neden olabileceği görülmektedir. MSG'nin CAM modelinde anjiyogenez ve oksidan-antioksidan denge üzerindeki etkilerine ilişkin literatürde daha önce yapılmış bir çalışma tespit edilemediği için araştırma sonuçlarımızın literatürdeki önemli bir eksikliği gidereceğini düşünmekteyiz.Öğe Investigation of Biological Effects of N- Butyl 2 Cyanoacrylate(Uşak Cerrahi Derneği, 2020) Karahan, Oğuz; Balkan, Mahmut; Hafız, Erhan; Khalil, EmcedAim: N-Butyl 2 cyanoacrylate is a frequently utilizing agent as a surgical adhesive. Biocompatibility analyses of N-Butyl 2 cyanoacrylate were evaluated in this study. Material and Method: Wistar Albino genus 16 healthy adult male (250 ± 5 gram) rats were divided into control and study groups. Determination of normal histological structure and routine physiologic observation was aimed in control group. In the study groups, 0.3 ml N-Butyl 2 cyanoacrylate injection were applied, via subcutaneous route for irritation and sensitization evaluation in the waist and back shaved group, via intramuscular route for cytotoxicity evaluation in the right femoral shaved group, and via tail vein injection for systemic toxicity evaluation in vascular administration group. Rats were sacrificed after 72. hours observation period and venous endothelium, muscular, dermal and epidermal tissues were examined histopathologically. Findings: Marked endothelial injury were detected in only intravenous administration. Extreme reaction and marked histopatholgical changes were not observed in regards of irritation, sensitization and cytotoxicity groups . Conclusion: Only intravascular administration of N-Butyl 2 cyanoacrylate, as a surgical adhesive usage, was lead advanced tissue injury in regards of local and systemic effects. However, this experimental model should be supported with clinical comprehensive studies.Öğe Investigation of the correlation between cardiac parameters and aortic diameter in patients with ascending aortic aneurysm(2022) Etli, Mustafa; Avnioğlu, Seda; Yılmaz, Halil; Karahan, OğuzBackground: Aortic aneurysms (AA) are enlargement of the aorta silently until diagnosing, not detectable on physical examination, and usually incidentally discovered during radiologic scanning for other reasons. It can get bigger sizes and can result in life-threatening outcomes if not detected early on. In this study, we aimed to determine the relationship between ascending aortic diameter and cardiac parameters that can be detected with tomography or/and echocardiography. Newly diagnosed (n: 85) ascending AA patients and healthy individuals (n: 86) who have not any thoracic pathology in computed tomography (CT) scans included to the study. Echocardiographically determined left atrial dimension (LAD), left ventricular end-diastolic diameter (LVDd), left ventricular end-systolic diameter (LVDs), left ventricular ejection fraction (LVEF) and the left ventricular posterior wall thickness (LVPWd) values of each patient were recorded. The thorax diameters, ascending aorta diameters and cardiac volume values recorded from CT scans. The obtained findings were statistically compared. Results: Positive correlation was found between aortic diameter and aging (p: 0.000). Increased thorax diameter and cardiac volume values were detected in ascending AA cases (p < 0.05). It was found to be ascending aortic diameter was positively correlated with thorax diameter and cardiac volume (0.50 < r ? 0.70) values and higher aortic diameter, cardiac volume, thorax diameter values were detected in male individuals when compared with the female gender. There was no significant correlation between LVEF, LVDd, and LVDs values and aortic diameter. Conclusions: Cardiac volume and thorax diameter were found as strongly correlated with the diameter of the ascending aorta. The clarifying of these parameters with larger cohorts might be beneficial for the estimation of the progression of ascending AA.Öğe Investigation of the endothelial response of super elastic braided stent: An experimental evaluation(Alanya Alaaddin Keykubat Üniversitesi, 2020) Karahan, Oğuz; Öcal, Naci; Sümer, Tuğçe; Hafız, Erhan; Khalil, EmcedAim: This study aimed to experimentally investigate the vascular biocompatibility of the new super elastic braided stents and ultrasonographically follow up the mid-term outcomes on the blood flow of stent-implanted vessels.Method: After designation of the study steps, stents were implanted into the iliac arteries of two ewes. The preoperative and postoperative blood flow and local findings were noted. The ewes were inspected periodically for abnormal body changes, and the stent-implanted vessels were checked with Doppler ultrasonography. The subjects were sacrificed at six months, and the iliac arteries were examined histopathologically. Results: During follow up an occlusive pattern was not observed in the stent-implanted vessels. The histopathological analysis revealed that both two stent area had no significant neointimal hyperplasia, despite sufficient re-endothelisation at the stent surface. Occlusive or stenotic patterns were not detected in both macroscopic and microscopic findings. Conclusion: According to the mid-term findings, our results show that the new super elastic bare stents have good vascular biocompatibility with high patency rates.Öğe Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD)(Springer Heidelberg, 2021) Etli, Mustafa; Canbolat, Gökhan; Karahan, Oğuz; Koru, MuratVascular hemodynamics play an important role in cardiovascular diseases. This work aimed to investigate the effects of an increase in ascending aortic diameter (AAD) on hemodynamics throughout a cardiac cycle for real patients. In this study, two scans of thoracic aortic aneurysm (TAA) subject with different AADs (42.94 mm and 48.01 mm) and a scan of a normal subject (19.81 mm) were analyzed to assess the effects of hemodynamics on the progression of TAA with the same flow rate. Real-patient aortic geometries were scanned by computed tomography angiography (CTA), and steady and pulsatile flow conditions were used to simulate real patient aortic geometries. Aortic arches were obtained from routine clinical scans. Computational fluid dynamics (CFD) simulations were performed with in vivo boundary conditions, and 3D Navier-Stokes equations were solved by a UDF (user-defined function) code defining a real cardiac cycle of one patient using Fourier series (FS). Wall shear stress (WSS) and pressure distributions were presented from normal subject to TAA cases. The results show that during the peak systolic phase pressure load increased by 18.56% from normal subject to TAA case 1 and by 23.8% from normal subject to TAA case 2 in the aneurysm region. It is concluded that although overall WSS increased in aneurysm cases but was low in dilatation areas. As a result, abnormal changes in WSS and higher pressure load may lead to rupture and risk of further dilatation. CFD simulations were highly effective to guide clinical predictions and assess the progress of aneurysm regions in case of early surgical intervention.Öğe Predicting Postoperative Atrial Fibrillation Using HARMS2-AF Score(2024) Öncel, Can Ramazan; Köseoğlu, Cemal; Dagasan, Goksel; Çoner, Ali; Ayhan, Selçuk; Akkaya, Özgür; Karahan, OğuzBackground: Postoperative atrial fibrillation (POAF) remains a common complication after cardiac surgery. The ability to accurately identify patients at risk through previous risk scores is limited. This study aimed to evaluate the new HARMS2-AF risk score to pre- dict POAF after coronary artery bypass grafting (CABG) surgery. Methods: In this retrospective cohort study, we included 265 patients undergoing CABG surgery from 2022-2023. Data were obtained from the medical files of the patients and hospital records. Each patient was assigned a HARMS2-AF risk score. A univariate and multivariate regression analyses were done to analyze independent predictors of POAF. Results: Of 265 patients, 49 had postoperative atrial fibrillation. HARMS2-AF score was significantly higher in patients with POAF. Age, sleep apnea, left atrial diameter (LAd), and HARMS2-AF score were independently associated with POAF. A HARMS2-AF score ? 4.5 predicted POAF with 91% sensitivity and 64% specificity (AUC = 0.787, 95% CI = 0.731- 0.842, P < .001). Conclusion: The HARMS2-AF score is a strong predictor of atrial fibrillation (AF) develop- ment after isolated CABG surgery. It can be used as a novel stratification tool to estimate AF after cardiac surgery.Öğe Relationship Between Blood and Pericardial Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Levels and Ventricular Functions in Coronary Artery Bypass Patients(2021) Kankılıç, Nazım; Karahan, Oğuz; Demirtaş, Sinan; Yavuz, Celal; Çalışkan, Ahmet; Güçlü, Orkut; Kaplan, İbrahimBackground: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like do- main- containing protein 1(SCUBE-1) is a cell surface protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the rela- tionship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent cor- onary artery bypass surgery. Materials and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dys- function markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups. Results: Statistical differences were observed in LVDs, IVSd, neutrophil, RBC, CK-MB, troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05). Conclusions: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.Öğe Structures of cytoskeleton and disease interactions(Alanya Alaaddin Keykubat Üniversitesi, 2019) Melekoğlu, Abdullah; Karahan, OğuzResearchers reported different basics for different kind of diseases with advanced technology. Meanwhile, investigators are focused on to clarify the interactions of basic cellular mechanisms recently. Therefore, cytoskeletal researches are gain importance due to this tendency. The cytoskeletal structures are responsible for interconnects between cell nucleus, cytoplasm and also extracellular matrix, whereby it create a communication link between cellular molecules and signalization transport. The cytoskeleton is constructed from three kinds of protein filaments as: actin filaments, intermediate filaments, and microtubules. The nature of these structures is briefly outlined and the literature review that is reporting relationship between cytoskeleton components and common disorders is presented in this paper.Öğe The importance of socio-economic determinants of health in the care of patients with peripheral artery disease: A narrative review from VAS(2023) Kolossvary, Endre; Farkas, Katalin; Karahan, Oğuz; Golledge, Jonathan; Schernthaner, Gerit-Holger; Karplus, Thomas; Bernardo, Jonathan James; Marschang, Sascha; Abola, Maria Teresa; Heinzmann, Monica; Edmonds, MichaelSocio-economic determinants of health (SDoH) include various nonmedical factors in the socio-economic sphere with a potentially significant impact on health outcomes. Their effects manifest through several mediators/moderators (behavioral characteristics, physical environment, psychosocial circumstances, access to care, and biological factors). Various critical covariates (age, gender/sex, race/ethnicity, culture/acculturation, and disability status) also interact. Analyzing the effects of these factors is challenging due to their enormous complexity. Although the significance of SDoH for cardiovascular diseases is well documented, research regarding their impact on peripheral artery disease (PAD) occurrence and care is less well documented. This narrative review explores to what extent SDoH are multifaceted in PAD and how they are associated with its occurrence and care. Additionally, methodological issues that may hamper this effort are addressed. Finally, the most important question, whether this association may contribute to reasonable interventions aimed at SDoH, is analyzed. This endeavor requires attention to the social context, a whole systems approach, multilevel-thinking, and a broader alliance that reaches out to more stakeholders outside the medical sphere. More research is needed to justify the power in this concept to improve PAD-related outcomes like lower extremity amputations. At the present time, some evidence, reasonable consideration, and intuitive reasoning support the implementation of various interventions in SDoH in this field. © The Author(s) 2023.Öğe Thromboembolic Disease in Patients With Cancer and COVID-19: Risk Factors, Prevention and Practical Thromboprophylaxis Recommendations–State-of-the-Art(2022) Dimakakos, Evangelos; Gomatou, Georgia; Catalano, Mariella; Olinic, Dan-Mircea; Spyropoulos, Alex C.; Falanga, Anna; Maraveyas, Anthony; Liew, Aaron; Schulman, Sam; Belch, Jill; Gerotziafas, Grigorios; Marschang, Peter; Karahan, OğuzCancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the other hand. Thromboprophylaxis is recommended for hospitalized patients with active cancer and high-risk outpatients with cancer receiving anticancer treatment. Universal thromboprophylaxis with a high prophylactic dose of low molecular weight heparins (LMWH) or therapeutic dose in select patients, is currently indicated for hospitalized patients with COVID-19. Also, prophylactic anticoagulation is recommended for outpatients with COVID-19 at high risk for thrombosis or disease worsening. However, whether there is an additive risk of thrombosis when a patient with cancer is infected with SARSCoV2 remains unclear. In the current review, we summarize and critically discuss the literature regarding the epidemiology of thrombotic events in patients with cancer and concomitant COVID-19, the thrombotic risk assessment, and the recommendations on thromboprophylaxis for this subgroup of patients. Current data do not support an additive thrombotic risk for patients with cancer and COVID-19. Of note, patients with cancer have less access to intensive care unit care, a setting associated with high thrombotic risk. Based on current evidence, patients with cancer and COVID-19 should be assessed with well-established risk assessment models for medically ill patients and receive thromboprophylaxis, preferentially with LMWH, according to existing recommendations. Prospective trials on well-characterized populations do not exist. © 2022 International Institute of Anticancer Research. All rights reserved.Öğe Unusual presentation of moyamoya disease with popliteal involvement: Case report and review of the literature(2021) Etli, Mustafa; Karahan, OğuzMoyamoya disease is a rare disorder that involves the cerebrovascular system. Usually, it leads to occlusion of the arteries of the cerebral system and causes cerebral circulatory complaints. A 48-year-old female patient was admitted to our clinic with intermittent claudication in both legs. Biphasic and monophasic waveform patterns were detected bilaterally in distal (trifurcation arteries) lower extremities with Doppler sonography. The patient therefore underwent systemic vascular examination. Computed tomography angiography revealed bilateral carotid occlusion at the level of supraclinoid segments, and opacifications were detected at the distal segments of the bilateral anterior cerebellar and middle cerebellar arteries. The patient was diagnosed with moyamoya disease, and anticoagulant treatment was started. In conclusion, most previous reports have presented the cerebrovascular involvement of moyamoya disease. However, this disease can involve different peripheral vascular systems and careful and systemic vascular examination is necessary for an exact diagnosis.Öğe Vascular effects of continuous hyperbaric oxygen exposure: experimental outlook(2023) Yavuz, Celal; Karahan, Oğuz; Akkaya, ÖzgürHyperbaric oxygen (HBO) treatment aims to restore tissue oxygenation by inhaling 100% oxygen in pressure rooms. Although beneficial effects have been reported with regard to re-oxygenated ischemic tissues, conflicting findings have been presented concerning the paradoxical tissue response following reperfusion and/or the different responses of non-ischemic normal tissues to increased oxygen exposure. The present study sought to experimentally investigate the impact of continuous HBO treatments on normal aortic tissue. New Zealand rabbits were placed in pressure rooms for 90 minutes per day under 2.5 atmospheric pressure and exposed to HBO for 28 days. Normal structural histology was obtained in the control group. Foam cells were detected in the aortic intimae, thickening and undulation were visualized in the endothelium, and localized separations were observed in the tunica media in the study group compared with the control group. Moreover, salient vasa vasorum was detected in the study group via histopathology. These findings suggest that continuous HBO exposures disrupt the normal vascular structure of a healthy aorta. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
