Yazar "Cankaya, Seyda" seçeneğine göre listele
Listeleniyor 1 - 20 / 27
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A RARE ENTITY OF ACQUIRED IDIOPATHIC GENERALISED ANHIDROSIS WHICH HAS BEEN SUCCESSFULLY TREATED WITH PULSE STEROID THERAPY: DOES THE HISTOPATHOLOGY PREDICT THE TREATMENT RESPONSE?(Literatura Medica, 2020) Oktem, Ece Ozdemir; Cankaya, Seyda; Uykur, Abdullah Burak; Erdem, Nazan Simsek; Yulug, BurakAcquired idiopathic generalised anhidrosis is an uncommon sweating disorder characterized by loss of sweating in the absence of any neurologic, metabolic or sweat gland abnormalities. Although some possible immunological and structural mechanisms have been proposed for this rare entity, the definitive pathophysiology is still unclear. Despite some successfully treated cases with systemic corticosteroid application, the dose and route of steroid application are controversial. Here, we present a 41-year-old man with lack of generalised sweating who has been successfully treated with high dose pulse intravenous prednisolone. We have discussed his clinical and histopathological findings as well as the treatment options in view of the current literature.Öğe Brain temperature in healthy and diseased conditions: A review on the special implications of MRS for monitoring brain temperature(Elsevier France-Editions Scientifiques Medicales Elsevier, 2023) Yulug, Burak; Velioglu, Halil Aziz; Sayman, Dila; Cankaya, Seyda; Hanoglu, LutfuBrain temperature determines not only an individual's cognitive functionality but also the prognosis and mor-tality rates of many brain diseases. More specifically, brain temperature not only changes in response to different physiological events like yawning and stretching, but also plays a significant pathophysiological role in a number of neurological and neuropsychiatric illnesses. Here, we have outlined the function of brain hyperthermia in both diseased and healthy states, focusing particularly on the amyloid beta aggregation in Alzheimer's disease.Öğe Cavernous sinus thrombosis due to mucor infection of ethmoid sinus(2024) Cankaya, Seyda; Çetin, Bahar Bakır; Oktem, Ece Ozdemir; Özşimşek, Ahmet; Lakadamyalı, Hatice; Yuluğ, Burak[Abstract Not Available]Öğe Cavernous sinus thrombosis due to mucor infection of ethmoid sinus(Galenos Publ House, 2024) Cankaya, Seyda; Cetin, Bahar Bakir; Oktem, Ece Ozdemir; Ozsimsek, Ahmet; Lakadamyali, Hatice; Yulug, Burak[Abstract Not Available]Öğe Chemogenetic inhibition of MCH neurons does not alter memory performance in mice(Elsevier France-Editions Scientifiques Medicales Elsevier, 2022) Mutlu-Burnaz, Ozlem; Yulug, Burak; Oncul, Merve; Celik, Esref; Atasoy, Nilufer Sayar; Cankaya, Seyda; Hanoglu, LutfuMemory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consoli-dation is one of the most important parts of the memory process, and one that can be affected by numerous neurodegenerative diseases. Hypothalamic melanin-concentrating hormone (MCH) neuronal activity has been of particular interest to researchers in terms of the association between sleep, neurodegenerative diseases, and memory consolidation. We used Pmch-Cre animals to investigate the role of MCH neuronal activity in memory consolidation. In order to observe the differences in memory consolidation, we chemogenetically inhibited MCH neurons using the DREADD method and measured hippocampus-dependent memory performance with a novel object recognition test applicable to early memory impairment in Alzheimer's disease. Our results revealed no significant improvement or worsening with MCH inhibition, suggesting that the role of MCH should now be evaluated in a wider setting.Öğe Cognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity(Cell Press, 2025) Yulug, Burak; Yalcinkaya, Ali; Safa, Shair Shah; Karakus, Ayse; Sayman, Dila; Cankaya, Seyda; Sayman, CeyhunTension-type headache (TTH) is a widespread primary headache disorder that causes mild to moderate pain, which may be seen together with cognitive deficits. It is unclear if TTH-linked cognitive impairment is associated with functional alterations. Seventy-five participants were enrolled in the study. Mini Mental State Evaluation (MMSE) and Montreal Cognition Assessment (MoCA) tests were applied to evaluate cognitive impairment. A neuroimaging analysis was applied to determine whether the hippocampus responsible for pain and cognition was affected in TTH patients. Our functional data revealed significant alterations in the connectivity of the subiculum, hippocampal fissure, and left whole hippocampus. Among the significant functional brain alterations observed, the right subiculum consistently interacted with MoCA scores and increased pain intensity. Our findings suggest that TTH patients with cognitive impairment may exhibit unique functional alterations in the hippocampus. This suggests a potential negative association between pain modulation and cognitive processes in the hippocampus that may be responsible for the increased risk of dementia in these patients.Öğe Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?(Pergamon-Elsevier Science Ltd, 2023) Avnioglu, Seda; Sahin, Caner; Cankaya, Seyda; Ozen, Ozkan; Dikici, Rumeysa; Yilmaz, Halil; Velioglu, Halil AzizPurpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.Öğe Depression is an independent risk factor for stroke reccurence and cognitive impairment in stroke patients(Springernature, 2025) Cankaya, Seyda; Safa, Shair Shah; Karakus, Ayse; Savcili, Mehmet; Hanoglu, Lutfu; Mardinoglu, Adil; Cetin, Fatma EcePost-stroke depression (PSD) is a significant sequela of cerebrovascular accidents, affecting a substantial proportion of stroke survivors. However, it is still unclear whether the existence of depression after stroke is an independent risk factor for stroke recurrence and if the increased risk of cognitive impairment in PSD is related to the location of stroke. We aimed to compare the role of cortical, subcortical and cortico-subcortical infarcts in the development of PSD and cognitive impairment, as well as the role of the existence of depression in stroke recurrence. In this study, a 52-week, randomised, double-blind study consisted of 1059 stroke patients (866 non-depressive and 193 untreated depressive persons) who were matched in terms of demographic and clinical parameters. The Mini Mental State Examination Test (MMSE), Executive function (Trail Making Test Part A), processing speed (colour naming condition of the Stroop test), episodic memory (Rey Auditory Verbal Learning Test [RAVLT], including delayed free recall), semantic memory (verbal fluency test [animal naming]), language processing (Boston Naming Test [(number correct]), visuospatial perception (the bells test) was assessed at the baseline. The lesion sites are subdivided as cortical, subcortical, and cortico-subcortical territory infarcts on MRI. The stroke recurrence ratio was also recorded after a year. In results, we observed a higher rate of depression associated with lesions affecting the cortico-subcortical structures in patients with PSD compared to non-depressive patients (p < 0.05). Our results further indicated impaired cognitive scores in patients with PSD compared to those with non-depressive individuals (p < 0.05). Regarding the risk of stroke recurrence, we also found an increased rate of stroke recurrence in PSD after 12 months (p < 0.05). In detail, binomial logistic regression analyses using the backward Wald method determined that patients with depression (p = 007; odds ratio (OR) = 1.64; CI 1.14-2.35), hypertension (p = 0.004; OR = 1.74; CI 1.19-2.55), atrial fibrillation (p = 0.007; OR = 1.61; CI 1.14-2.28) and older age (p = 0.019; OR = 1.02; CI 1.003-1.03) were significantly predictors for stroke recurrency. Our regression analysis further revealed that PSD was a predictive factor for disabling cognitive test scores (impaired executive function [p < 0.001; OR = 4.51; CI 3.24-6.27], reduced processing speed [p < 0.001; OR = 4.29; CI 3.12-5.91], episodic memory [p < 0.001; OR = 4.65; CI 3.37-6.42), semantic memory [p < 0.001; OR = 4.79; 3.47-6.61], visuospatial [p < 0.001; OR = 6.10; CI 4.36-8.55], and language function [p < 0.001; OR = 5.086; CI 3.67-7.05]) after adjusting for age and education. In conclusion, the present study provides strong evidence confirming the importance of depression in predicting cognitive impairment and recurrence in stroke patients. Despite these positive findings, our findings warrant the performance of further research to demonstrate the efficacy of treatment on stroke recurrence, together with other vascular risk factors and cognitive disorders.Öğe Different metabolic and clinical profiles between patients with pure Alzheimer dementia and epileptic Alzheimer dementia: a metabolic study(2022) Oktem, Ece Ozdemir; Kadak, Kübra Soğukkanlı; Cakır, Tansel; Özşimşek, Ahmet; Cankaya, Seyda; Hanoğlu, LütfüAim: To investigate the clinical characteristics and cerebral FDG PET metabolisms of dementia patients who were also diagnosed with epilepsy and compare the differences with pure Alzheimer dementia patients.Methods: In this case-control study, a total of 14 patients, 7 patients with pure Alzheimer disease as a control group and 7 age and gender-matched patients with Alzheimer disease and concomitant epilepsy as a study group, were included. Detailed neurocognitive battery and brain fludeoxyglucose positron emission tomography (FDG PET-CT) were performed for all subjects.Results: In comparison of neurocognitive test scores, there was no significant difference between the study and control groups. However, geriatric depression scale scores were significantly lower in study group than the controls (p= 0.026). In cerebral FDG-PET CT profiles of subjects we detected significantly lower metabolism in left and right cerebellum, left lentiform nucleus, right thalamus and vermis in the study group (p=0.008, p=0.023, p=0.003, p=0.002, p=0.002, respectively). In the right parietotemporal cortex and right and left associative visual cortex, we found higher metabolism in the study group than controls (p=0.023, p=0.012, p=0.003, respectively).Conclusion: Epileptic patients with Alzheimer’s dementia may have distinct clinical and metabolic profiles, than pure Alzheimer’s disease patients. Even if there is no difference in the neurocognitive clinical scores of the patients, depression and related functional abnormalities may be a biomarker of epileptic AD.Öğe Differentiating MCI from depression through verbal memory scores(Wiley, 2024) Cankaya, Seyda; Yalciner, Betul; Yilmaz, Melek Kandemir; Yulug, BurakINTRODUCTION: The present study aims to assess the differences between major depressive disorder (MDD) and mild cognitive impairment (MCI) in terms of verbal learning profile together with structural changes in the brain on magnetic resonance imaging (MRI) and to reveal predictive factors for MCI. METHODS: Fifty-six patients with MDD and 31 MCI subjects were assessed using the Turkish Verbal Memory Processes Test (VMPT). Brain MRI was used to evaluate sulcal atrophy (SA), ventricular atrophy, periventricular white matter hyperintensity (WMH), subcortical WMH, basal ganglia infarct, medial temporal lobe atrophy, and infratentorial infarct scores based on the Modified Visual MRI Rating Scale (MVMRS). The symptoms of depression were evaluated with the Beck Depression Inventory in both groups. Demographic factors, VMPT scores, and MVMRS scores between MDD and MCI groups were compared. Also, potential predictors of MCI were analyzed by binary logistic regression analyses. RESULTS: The total scores of VMPT and the scores of VMPT subgroups, including immediate memory, highest learning, total learning, and delayed recall, were significantly higher in the MDD groups compared to MCI patients (Mann-Whitney U, Student's t-test, p < 0.05), indicating that higher scores were associated with better memory. The total MVMRS score and a subgroup of MVMRS, the SA score, were significantly higher in MCI patients compared to the MDD group, suggesting more atrophic changes and a higher burden of infarction in MCI patients. In our statistical analyses, impaired immediate memory (p < 0.001; OR = 6.002; 95% CI: 1.996-18.042), increased SA (p = 0.008; OR = 1.522; 95% CI: 1.118-2.073), and education (p = 0.028; OR = 0.84; 95% CI: 0.719-0.981) were significant predictive values obtained through backward Wald elimination in the binary logistic regression model for detecting MCI. CONCLUSION: Our findings suggest that VMPT may potentially represent a novel neuropsychiatric test that might be combined with MRI-based morphometric evaluation methods, such as MVMRS.Öğe Exploring Cognitive Impairment in Patients With Bilateral Capsular Genu Lesions(Amer Psychiatric Publishing, Inc, 2022) Kumral, Emre; Cetin, Fatma Ece; Ozdemir, Huseyin Nezih; Cankaya, Seyda; Schabitz, Wolf-Rudiger; Yulug, BurakObjective: The authors investigated for presence of cognitive impairment after occurrence of bilateral lesions of the genu of the internal capsule (GIC). Clinical and neuropsychological features of unilateral GIC lesions have previously been studied, but the cognitive profile of bilateral lesions of the GIC has not been fully explored. Methods: An investigation was conducted of neurocognitive deficits and computerized tomography MRI findings among 4,200 stroke patients with bilateral GIC involvement who were admitted to the hospital between January 2010 and October 2018. Results: Eight patients with bilateral lesions of the capsular genu were identified and their data analyzed. Overall, behavioral and cognitive dysfunction were characterized by impairment of frontal, memory, and executive functions. Attention and abstraction were present among all eight patients (100%); apathy, abulia, and executive dysfunctions, among seven (87.5%); global mental dysfunction and planning deficits, among six (75.0%); short-term verbal memory deficits and language dysfunctions, among five (62.5%); long-term verbal memory deficits, among four (50.0%); and spatial memory deficits, reading, writing, counting dysfunctions, and anarthria, among two (25.0%). Four of the patients (50.0%) without a history of cognitive disorder showed severe mental deterioration compatible with the clinical picture of dementia. A clinical picture of dementia was still present in these patients 6 months after stroke. Conclusions: Bilateral lesions of the capsular genu appearing either simultaneously or at different times were significantly associated with executive dysfunctions.Öğe High dose corticosteroid causes bradycardia in patients with multiple sclerosis(Wiley, 2024) Sayman, Ceyhun; Celik, Humeyra; Cankaya, Seyda; Oktem, Ece Ozdemir; Yulug, Burak[Abstract Not Available]Öğe Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study(Academic Press Inc Elsevier Science, 2025) Cankaya, Seyda; Ayyildiz, Behcet; Sayman, Dila; Duran, Umutcan; Ucak, Dogukan; Karaca, Ramazan; Ayyildiz, SevilayThe etiology of cognitive decline linked to migraine remains unclear, with a growing recurrence rate and potential increased dementia risk among sufferers. Cognitive dysfunction has recently gained attention as a significant problem among migraine sufferers that can be related to alterations in hippocampal function and structure. This study explores hippocampal subfield connectivity and volume changes in migraine patients. We recruited 90 individuals from Alanya University's Neurology Department, including 49 migraine patients and 41 controls, for functional and anatomical imaging. Using the CONN toolbox and FreeSurfer, we assessed functional connectivity and subfield volumes, respectively. Montreal Cognitive Assessment (MOCA) was used to assess cognition in the entire sample. As a result, migraine patients exhibited significantly lower MOCA scores compared to controls (p<.001). Also, we found significant differences in hippocampal subfields between migraine patients and control groups in terms of functional connectivity after adjusting for years of education; here we showed that the left CA3 showed higher connectivity with right MFG and right occipitolateral cortex. Furthermore, the connectivity of left fimbria with the left temporal lobe and hippocampus and the connectivity of the right hippocampal-tail with right insula, heschl's gyrus, and frontorbital cortex were lower in the migraineurs. Additionally, volumes of specific hippocampal subfields were significantly lower in the migraineurs (whole hippocampus p = 0.004, whole hippocampus head p = 0.003, right CA1 head p = 0.006, and right HATA p = 0.005) compared to controls. In conclusion, these findings indicate that migraine-associated cognitive impairment involves significant functional and structural brain changes, particularly in the hippocampus, which may heighten dementia risk. This pioneering study unveils critical hippocampal alterations linked to cognitive function in migraine sufferers, underscoring the potential for these changes to impact dementia development.Öğe Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?(Wiley, 2023) Yulug, Burak; Ayyildiz, Behcet; Ayyildiz, Sevilay; Sayman, Dila; Salar, Ali Behram; Cankaya, Seyda; Ozdemir Oktem, EceAlthough no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID-19 on general cognitive performance, hippocampal volume, and connections using structural and seed-based connectivity analysis. We showed that COVID patients exhibited considerably worse cognitive functioning and increased hippocampal connectivity supported by the strong correlation between hippocampal connectivity and cognitive scores. Our findings of higher hippocampal connectivity with no observable hippocampal morphological changes even in mild COVID cases may be represent evidence of a prestructural compensatory mechanism for stimulating additional neuronal resources to combat cognitive dysfunction as recently shown for the prodromal stages of degenerative cognitive disorders. Our findings may be also important in light of recent data showing that other viral infections as well as COVID may constitute a critical risk factor for the development of AD. To our knowledge, this is the first study that investigated network differences in COVID patients, with a particular focus on compensatory hippocampal connectivity.Öğe Mezensefalik Kanamalı Hastalarda Fonksiyonel Sonuçlara Yönelik Prognostik Faktörler(2023) Oktem, Ece Ozdemir; Kumral, Emre; Çetin, Fatma Ece; Özşimşek, Ahmet; Dorukoğlu, Mehmet Mesut; Cankaya, Seyda; Yuluğ, BurakAmaç: Mezensefalik kanama (MH), spontan intraparankimal kanamanın nadir görülen bir prezentasyonudur. Bu çalışma, mezensefalik kanamalardaki prognostik parametreleri değerlendirmeyi amaçlamaktadır. Yöntem: Çalışmamızda; izole mezensefalik kanamalı olgular PRISMA (Sistematik İncelemeler ve Meta-Analizler için Tercih Edilen Raporlama Öğeleri) beyanına göre kapsamlı şekilde taranmıştır. Literatürde yer alan BT veya MRG ile kanıtlanmış 62 uygun vaka ve bunlara MRG ile doğrulanmış altı vaka olmak üzere 68 hasta çalışmaya dâhil edildi. Hastalar modifiye Rankin Skalasına göre (mRS), iyi sonlanım (0–2 puan) ve kötü sonlanım (3–6 puan) olarak iki gruba ayrılarak, prognostik parametreler istatistiksel olarak karşılaştırıldı. Bulgular: Çalışılan 68 hastanın 26’sının (%38) bilinci açık, 22’si (%32) letarjik, 20’si (%29) stupor veya koma ile başvurdu. İyi prognoz gösteren olguların 26’sında (%65), kötü prognoz gösterenlerin 12’sinde (%43) idiopatik kanama gözlendi (p=0,059). Tek değişkenli analizlerde, arteriyovenöz malformasyonlar (p=0,33) ve kavernomlar (p=0,19) prognoz ile ilişkili bulunmadı. Çoklu lojistik regresyon analizlerinde; hipertansiyon (OR, 51,22; CI%95, 1,92–1370,24; P=0,019, bilinç durumu (OR, 133,54; CI%95, 1,61–1113,3; p=0,03), başvuru anındaki NIHSS (OR, 57,23; CI%95, 2,87–1141,2; p=0,008) ve ventrodorsal kanama boyutu (?1 cm) (OR, 61,83; CI%95, 2,15–1779,2; p=0,016), kötü prognoz ile ilişkili bulundu. Mezensefalik kanamadan üç ay sonra, 40 hastanın (%59) klinik olarak iyi durumda, 28 (%41) hastanın klinik olarak kötü durumda olduğu, sekiz hastanın ise (%12) kaybedildiği gözlendi. Sonuç: Bu bulgular, hemorajinin ventrodorsal boyutunun ve inme başlangıcındaki klinik şiddetin mezensefalik kanama sonrası fonksiyonel sonuç açısından olası belirleyicileri olduğunu göstermektedir.Öğe Multi-omics analysis reveals the key factors involved in the severity of the Alzheimer's disease(Bmc, 2024) Meng, Lingqi; Jin, Han; Yulug, Burak; Altay, Ozlem; Li, Xiangyu; Hanoglu, Lutfu; Cankaya, SeydaAlzheimer's disease (AD) is a debilitating neurodegenerative disorder with a global impact, yet its pathogenesis remains poorly understood. While age, metabolic abnormalities, and accumulation of neurotoxic substances are potential risk factors for AD, their effects are confounded by other factors. To address this challenge, we first utilized multi-omics data from 87 well phenotyped AD patients and generated plasma proteomics and metabolomics data, as well as gut and saliva metagenomics data to investigate the molecular-level alterations accounting the host-microbiome interactions. Second, we analyzed individual omics data and identified the key parameters involved in the severity of the dementia in AD patients. Next, we employed Artificial Intelligence (AI) based models to predict AD severity based on the significantly altered features identified in each omics analysis. Based on our integrative analysis, we found the clinical relevance of plasma proteins, including SKAP1 and NEFL, plasma metabolites including homovanillate and glutamate, and Paraprevotella clara in gut microbiome in predicting the AD severity. Finally, we validated the predictive power of our AI based models by generating additional multi-omics data from the same group of AD patients by following up for 3 months. Hence, we observed that these results may have important implications for the development of potential diagnostic and therapeutic approaches for AD patients.Öğe Multi-omics characterization of improved cognitive functions in Parkinson's disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial(Oxford Univ Press, 2025) Yulug, Burak; Altay, Ozlem; Li, Xiangyu; Hanoglu, Lutfu; Cankaya, Seyda; Velioglu, Halil A.; Lam, SimonParkinson's disease is primarily marked by mitochondrial dysfunction and metabolic abnormalities. We recently reported that the combined metabolic activators improved the immunohistochemical parameters and behavioural functions in Parkinson's disease and Alzheimer's disease animal models and the cognitive functions in Alzheimer's disease patients. These metabolic activators serve as the precursors of nicotinamide adenine dinucleotide and glutathione, and they can be used to activate mitochondrial metabolism and eventually treat mitochondrial dysfunction. Here, we designed a randomized, double-blinded, placebo-controlled phase II study in Parkinson's disease patients with 84 days combined metabolic activator administration. A single dose of combined metabolic activator contains L-serine (12.35 g), N-acetyl-L-cysteine (2.55 g), nicotinamide riboside (1 g) and L-carnitine tartrate (3.73 g). Patients were administered either one dose of combined metabolic activator or a placebo daily for the initial 28 days, followed by twice-daily dosing for the next 56 days. The main goal of the study was to evaluate the clinical impact on motor functions using the Unified Parkinson's Disease Rating Scale and to determine the safety and tolerability of combined metabolic activator. A secondary objective was to assess cognitive functions utilizing the Montreal Cognitive Assessment and to analyse brain activity through functional MRI. We also performed comprehensive plasma metabolomics and proteomics analysis for detailed characterization of Parkinson's disease patients who participated in the study. Although no improvement in motor functions was observed, cognitive function was shown to be significantly improved (P < 0.0000) in Parkinson's disease patients treated with the combined metabolic activator group over 84 days, whereas no such improvement was noted in the placebo group (P > 0.05). Moreover, a significant reduction (P = 0.001) in Montreal Cognitive Assessment scores was observed in the combined metabolic activator group, with no decline (P > 0.05) in the placebo group among severe Parkinson's disease patients with lower baseline Montreal Cognitive Assessment scores. We showed that improvement in cognition was associated with critical brain network alterations based on functional MRI analysis, especially relevant to areas with cognitive functions in the brain. Finally, through a comprehensive multi-omics analysis, we elucidated the molecular mechanisms underlying cognitive improvements observed in Parkinson's disease patients. Our results show that combined metabolic activator administration leads to enhanced cognitive function and improved metabolic health in Parkinson's disease patients as recently shown in Alzheimer's disease patients. The trial was registered in ClinicalTrials.gov NCT04044131 (17 July 2019, https://clinicaltrials.gov/ct2/show/NCT04044131).Öğe Prognostic Factors For Functional Outcome in Patients with Mesencephalic Hemorrhage(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2023) Oktem, Ece Ozdemir; Kumral, Emre; Bayam, Fatma Ece; Ozsimsek, Ahmet; Dorukoglu, Mehmet Mesut; Cankaya, Seyda; Yulug, BurakIntroduction: Mesencephalic hemorrhage (MH) is a rare presentation of spontaneous intraparenchymal hemorrhage. This study aims to evaluate prognostic parameters of the MH outcome. Methods: We conducted an extensive search in the literature for cases with spontaneous, isolated mesencephalic hemorrhage. The study was conducted according to the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Sixty-two eligible cases have been reported in the literature as proven by CT or MRI, and to these, we added six cases confirmed by MRI. The modified Rankin Scale (mRS) was dichotomized into two groups as the favorable outcome (FO; score, 0-2) and unfavorable outcome (UO; score, 3-6). Results: Of the 68 patients studied, 26 (38%) presented with normal consciousness, 22 (32%) with lethargy, and 20 (29%) with stupor or coma. There was no cause of hemorrhage in 26 (65%) patients with FO and 12 (43%) with UO (p=0.059). In univariate analyses, neither arteriovenous malformations (p=0.33) nor cavernomas (p=0.19) were associated with outcome. Multiple logistic regression analysis revealed that hypertension (OR, 51.22; CI95%, 1.92-1370.24; P=0.019), consciousness (OR, 133.54; CI95%, 1.61-1113.3; P=0.03), NIHSS at admission (OR, 57.23; CI95%, 2.87-1141.2; p=0.008), and ventrodorsal hemorrhage size (=1 cm) (OR, 61.83; CI95%, 2.15-1779.2; p=0.016) were significantly associated with UO. Three months after stroke, 40 patients (59%) had FO, 28 (41%) had UO, and 8 (12%) died. Conclusion: These results suggest that ventrodorsal size of hemorrhage and clinical severity at stroke onset are possible predictors of functional outcome after mesencephalic hemorrhage.Öğe Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method(Lippincott Williams & Wilkins, 2021) Avnioglu, Seda; Velioglu, Halil Aziz; Cankaya, Seyda; Yulug, BurakBackground Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are controversial findings regarding these volume alterations in MDD indicating even to increased volumes in some specific regions in MDD patients. Methods This study is a case-controlled study including 23 depression patients and 15 healthy subject person and 20-38 years of age, who have been treated at the Neurology and Psychiatry Department here. We compared specific anatomic regions between drug-free MDD patients and control group through MRI-Cloud, which is a novel brain imaging method that enables to analyze multiple brain regions simultaneously. Results We have found that frontal, temporal, and parietal hemispheric volumes and middle frontal gyrus, inferior frontal gyrus, superior parietal gyrus, cingulum-hippocampus, lateral fronto-orbital gyrus, superior temporal gyrus, superior temporal white matter, middle temporal gyrus subanatomic regions were significantly reduced bilaterally in MDD patients compared to the control group, while striatum, amygdala, putamen, and nucleus accumbens bilaterally increased in MDD group compared to the control group suggesting that besides the heterogeneity among studies, also comorbid factors such as anxiety and different personal traits could be responsible for these discrepant results. Conclusion Our study gives a strong message that depression is associated with altered structural brain volumes, especially, in drug-free and first-episode MDD patients who present with similar duration and severity of depression while the role of demographic and comorbid risk factors should not be neglected.Öğe Repetitif Transkraniyal Manyetik Stimülasyon ile Alzheimer Hastalığında Hipokampal N-Asetilaspartat Düzeyinin ve Görsel Hafıza Skorlarının İyileştirilmesi(2024) Velioglu, Halil Aziz; Sayman, Dila; Hanoğlu, Lütfü; Ertan, Gulhan; Cankaya, Seyda; Yuluğ, BurakAlzheimer hastalığının (AH) patofizyolojisine yönelik yapılan son çalışmalar, hipokampal işlevsellikle ilgili çeşitli kognitif bozuklukları içermektedir. Bununla birlikte, mevcut klinik araştırmalar, AH’nin heterojen bilişsel spektrumunun tam kapsamını göz önünde bulunduramamakta ve kesin tanısal ve terapötik sonuçlar çıkarmak için gereken spesifik yöntemlerin eksikliğine neden olmaktadır. Bu, aynı zamanda AH’li insanlarda tanı ve tedavi rejimlerini uyarlamak için in-vivo metabolik ölçümlerini de içermektedir. Manyetik rezonans spektroskopisi ve tekrarlayan transkraniyal manyetik stimülasyon (rTMS), AH tedavisinde modifiye edilmesi gereken iki yeni tanı ve tedavi yaklaşımıdır. Bu çalışmada, rTMS tedavisi öncesi ve sonrası in-vivo hipokampal metabolitleri değerlendirerek AH’li kişilerde rTMS’nin altta yatan terapötik rolünü araştırmayı amaçladık. Önceki çalışmamızda fMRI verileri kullanılarak elde edilen verilere ve literatürde bildirilen referanslara dayanarak, bu çalışmada rTMS stimülasyonundan sonra hipokampal NAA verilerini kullanmaya karar verdik ve NAA seviyelerinin anlamlı derecede yükseldiğini gördük. Bildiğimiz kadarıyla, başka hiçbir çalışma, rTMS’nin AH’li insanlarda hipokampal metabolitler üzerindeki etkisini değerlendirmemiştir.
