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    Comparison Of Diaphragm Thickness Values In Cases of Adenotonsillectomy Before And After The Operation
    (2023) Toprak, Hatice; Aydogan, Eyup; Tire, Yasin
    Aim: The ultrasonographic assessment in the operating room tends to increase daily, and ultrasonography is a method used to evaluate the thickness of the diaphragm. Measurement of the thickness of the diaphragm is a parameter that can be used to decide before separation from mechanical ventilation and extraction. In these cases where intubated and extubated at the end of the operation, it is planned to examine the ratio of the aperture muscle thickness to each other in the last inspirium and exprium before extubation. Determining the current ratio may be meaningful for determining the extubation time. Material and Method: In the study, 60 patients, who were in the physical state of ASA I and II, 3-12 age range, and who were scheduled for elective adenotonsillectomy operation were included. Age, gender, body mass index (BMI), and operation time data of patients were recorded. Before and after the procedure, inspiratory and exprituar diaphragm thicknesses were measured by ultrasonography. In addition, the ratio of the last inspirium and the diaphragm muscle thicknesses in the last expiration were also calculated. Results: There was no significant difference between the pre-operation values and the end of the operation in the diaphragm thickness measurements. The incidence of laryngospasm was 1.5 %. Conclusion: Diaphragm thickness measurements with ultrasound have many benefits but further studies are needed.
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    Determination of preoperative hypertension prevalence and awareness in patients before elective surgery
    (Bayrakol Medical Publisher, 2023) Aydogan, Eyup; Yildiz, Munise; Kozanhan, Betul; Ekinci, Nuran Akinci
    Aim: This study was conducted to reduce target organ damage and perioperative morbidity by early diagnosis of uncontrolled hypertension, considering the morbidities associated with hypertension.Material and Methods: The data of 400 volunteer patients who met the sample eligibility criteria and applied to the anesthesiology outpatient clinic before elective surgery in Konya City Hospital were analyzed. The socio-demographic characteristics, anthropometric data, and the average of two blood pressure measurements of the patients were recorded. Hypertension (HT) was defined as systolic blood pressure (SBP) & GE; 130 mmHg and/or diastolic blood pressure (DBP) & GE; 80 mmHg. Body Mass Index (BMI) and Body Roundness Index (BMI) were calculated with the formula. They were categorized as average weight (BMI <25 kg m-2), overweight (25 & LE; BMI <30 kg m-2), and obese (BMI & GE; 30 kg m-2) according to their BMI.Results: Seven out of ten adult patients admitted to the anesthesiology outpatient clinic before elective surgery were hypertensive. While 60% of these were unaware of having HT, only 22% of those diagnosed had blood pressure under control. Discussion: As a result of our study, the high prevalence and low awareness of blood pressure indicate that hypertension is a common problem in our country. Furthermore, since HT remains a significant risk factor for morbidity and mortality, preoperative evaluation of patients provides a unique opportunity to diagnose and initiate treatment.
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    Evaluation of clinical results of esmarch bandage application in giant saphenous vein closure during endovenous glue ablation
    (Clinics Cardive Publ Pty Ltd, 2024) Karahan, Oguz; Akkaya, Ozgur; Aydogan, Eyup
    Background: In recent years, the endovenous technique has been presented as a good alternative to surgery in the treatment of patients with lower extremity varicose veins. However, its effectiveness in very advanced saphenous vein diameters is controversial. In this study, we investigated the results of an endovenous glue ablation closure system applied with an esmarch bandage in saphenous veins with very large diameters. Methods: Eighty-nine patients who were operated on for varicose veins were divided into three groups according to their saphenous vein diameters: less than 10 mm (group 1), between 10 and 15 mm (group 2), and larger than 15 mm (group 3). Endovenous closure was performed with n-butyl cyanoacrylate in all patients. An esmarch bandage was applied during the procedure to all patients, except for the group with a diameter of less than 10 mm. This group underwent the standard procedure. All patients were followed up for six months after the procedure and postoperative symptoms, complications and closure rates were recorded. Results: There was complete closure of all veins in the first month postoperatively. While no thrombophlebitis was observed in group 3, thrombophlebitis was detected in two patients in groups 1 and 2. In the third month, minimal saphenofemoral reflux was observed in two (4.2%) patients in group 1 and in one (4.3%) in group 2. In the sixth month, minimal saphenofemoral reflux was detected in three (6.3%) patients in group 1 and in one (4.3%) in group 2. No residual leakage was observed in group 3 (p = 0.001). In all groups, the severity score regressed significantly in the postoperative sixth month. However, the most significant symptomatic regression was observed in group 3, which had the largest saphenous diameters and we used an esmarch bandage during closure (p = 0.000).Conclusion: Our findings support the idea that the application of an esmarch bandage during endovenous closure improves clinical outcomes, especially in saphenous veins with larger diameters.
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    Experimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model
    (Sage Publications Inc, 2025) Ozgul, Mustafa; Aydogan, Eyup
    Background: Sacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model. Methods: The chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10(-7) M, 10(-6) M, 10(-5) M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets' effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded. Results: There was no significant difference between the control and drug-free pellet groups (12.4 +/- 2.8 vs. 14.1 +/- 1.3 junctions per ROI, p = 0.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3 +/- 3.8 per ROI in Group I (10(-7) M concentration); 21.6 +/- 5.4 per ROI in Group II (10(-6) M concentration); 22.9 +/- 8.1 per ROI in Group III (10(-5) M concentration) (p < 0.001). Conclusion: Our findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.
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    Pain Management During and After Carotid Endarterectomy Cases Performed with Regional and İnfiltration (Tumescent) Anesthesia
    (Dubai Iranian Hosp, 2025) Akkaya, Ozgur; Aydogan, Eyup
    Background and Objectives: Previous studies have discussed the advantages of different anesthesia techniques in carotid artery surgery. However, there is not enough data comparing local anesthesia and block techniques. In this retrospective study, pain management during and after carotid endarterectomy cases is performed with regional and infiltration (tumescent) anesthesia. Methods: Endarterectomy cases performed in our clinic between 2022 and 2023 were examined. The patient's age, gender, comorbidities, type of anesthesia (infiltration anesthesia, deep cervical plexus block), and postoperative pain levels of the patients were evaluated. Results: Body Mass Index (BMI) means of patients were statistically significant and higher in cervical block patients compared to infiltration patients (P < 0.05) Operation pain was significantly correlated with BMI ( r = 0.346 ; r < 0.01 ) and medicine usage ( r = - 0.252 ; P < 0.05 ) Pain after 24h was significantly correlated with operation duration ( r = - 0.296 ; P < 0.05 ) and medicine ( r = - 0.286 ; P < 0.05 ) The effect of medicine on operation pain was insignificant multivariate level (P > 0.05) , whereas the effect of BMI was significant ( B = 0.055 ; P < 0.05 ) with controlling anesthesia type. Pain level according to BMI was significant with 0.717 Area Under Curve (AUC) value meaning 71.7% pain predictive value of BMI. Patients having a BMI over 22.85 had high pain with 93.2% positive predictive and 42.9% negative predictive level. Effects of medicine and operation duration on VAS after 24 hours were insignificant at the univariate level (P > 0.05) Conclusion: Although there is no medical justification, retrospectively, cervical block was preferred more in patients with high BMI. High BMI predicts intraoperative pain, suggesting tailored analgesia for obese patients. Further researches are needed to understand cervical block preference for higher BMI and its effects on operation pain.