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Öğe ANALYSIS OF MAGNETIC RESONANCE 3D T1 SEGMENTATIONS OF CEREBELLUM IN VESTIBULAR NEURITIS PATIENTS(2022) Ocak, Mert; Yılmaz, Seher; Avnioglu, Seda; Sahın, Caner; Tokpinar, Adem; Ateş, ŞükrüAim: Vestibular neuritis is one of the most common causes of acute spontaneous vertigo. In our study, we aimed to analyze the cerebellum volume and cerebellum connections in patients diagnosed with vestibular neuritis using the VolBrain program. Materials and Methods: 10 patients and 9 healthy (control) persons were included in the study. Automatic segmentation and volumetric analysis of cerebellum and cerebellum lobules were investigated using magnetic resonance images (MRI) of 19 people. Results: The volumes of 10 cerebellar regions were measured and compared between the patient and control groups. The total volume of the cerebellum was calculated as 123.82 ± 2.57 cm3 in the control group and 119.97 ± 4.15 cm3 in the patient group. In addition, the average amount of gray matter in the cerebellum was 90.63 ± 6.59 cm3 in the control group and 87.87 ± 16.12 cm3 in the patient group. We found volumetric changes to be statistically significant. Conclusion: By performing cerebellum segmentation with 3D T1 sequence of MRI images taken from patients diagnosed with vestibular neuritis, volume measurement and more detailed examinations can be performed easily with the help of the volBrain program. Moreover, its low cost and its usefulness in diagnosis suggest that this method will be beneficial.Öğe Analysis of the brain MR image of a patient with anosmia due to Covid-19 by voxel-based morphometry-Case report(Wiley, 2021) Avnioglu, Seda; Etli, Mustafa; Dikici, Rumeysa[Abstract Not Available]Öğe Correlation of some anatomical angles of the shoulder with rotator cuff syndrome(Wolters Kluwer Medknow Publications, 2023) Candan, Busra; Torun, Ebru; Dikici, Rumeysa; Avnioglu, Seda; Gunal, Mehmet YalcinBackground: Shoulder movement occurs through the coordinated work of muscles, tendons, ligaments, and bones, primarily that affect the glenohumeral joint. Some distances and the angles between the bones forming this joint are important in shoulder pathologies. In this study, we aimed to determine the evaluation of nine different radiological parameters related to acromion and humerus in rotator cuff syndrome and control group patients. Materials and Methods: A total of 400 patients' routine clinic radiographs were retrospectively assessed, which have rotator cuff syndrome (n = 210), and control group (n = 190). We measured the critical shoulder angle (CSA), distance of glenoid-acromion (GA), distance of glenoid-humeral head (GH), acromial index, lateral acromial angle (LAA), total shoulder arthroplasty angle (TSA), reverse shoulder arthroplasty angle (RSA), Point T represents the superior border of the glenoid cavity, Point S represents the inferior border of the glenoid cavity, point R represents the intersection of the supraspinatus fossa line with the glenoid surface. RST angle, and greater tuberosity angle (GTA) angle. We determined the type of acromion. Results: We determined that the GH, TSA, RST, and GTA were significantly different between rotator cuff syndrome and control group patients. When we evaluated the acromion type, Type 2 was the most common type. Different from the literature, when we evaluated the relationship between acromion types and angles, we determined that LAA, GA, and TSA parameters were significantly different between acromion types. Conclusions: In this study, we determined the importance of measurements and angles in rotator cuff syndrome. We think that the relationship between acromion types and parameters can contribute to the literature. Moreover, we believe that our study will contribute to the literature in terms of gathering many angles that are important in shoulder pathologies in a single study.Öğe Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection?(Pergamon-Elsevier Science Ltd, 2023) Avnioglu, Seda; Sahin, Caner; Cankaya, Seyda; Ozen, Ozkan; Dikici, Rumeysa; Yilmaz, Halil; Velioglu, Halil AzizPurpose: Neuroimaging studies have shown that anosmia is accompanied by a decreased olfactory bulb volume, yet little is known about alterations in cerebral and cerebellar lobule volumes. The purpose of this study was to investigate structural brain alterations in anosmic patients.Methods: Sixteen anosmic patients (mean age 42.62 +/- 16.57 years; 6 women and 10 men) and 16 healthy controls (mean age 43.37 +/- 18.98 years; 9 women and 7 men) were included in this retrospective study. All subjects who underwent magnetic resonance imaging scans were analyzed using VolBrain and voxel-based morphometry after olfactory testing.Results: Despite being statistically insignificant, analysis using VBM revealed greater gray matter (GM) and white matter in the anosmia group compared to the healthy subjects. However, decreased GM (p < 0.001) and increased cerebellar (p = 0.046) volumes were observed in the anosmic patients.Conclusions: The study revealed structural brain alterations in specific areas beyond the olfactory bulb. Our re-sults indicate that the cerebellum may play an exceptional role in the olfactory process and that this will be worth evaluating with further dynamic neuroimaging studies.Öğe Effect of combination treatment of protocatechuic acid with 5-fluorouracil and oxaliplatin on colon cancer Caco-2 cell line(Natl Inst Science Communication-Niscair, 2023) Yildiz, Fatma; Eciroglu, Hamiyet; Ovey, Ishak Suat; Avnioglu, SedaAmong the most common antitumor drugs used in the treatment of colon cancer are 5-fluorouracil and oxaliplatin (5-FU and OXA). However, both these drugs have many side effects, and hence there is a need for new treatment\approach to reduce the side effects aas well as drug concentration. In this context, here, we investigated the effect of addition of protocatechuic acid (PCA) onto either monotherapies or combination therapies of 5-FU and OXA on the human colon cancer (Caco-2) cell line. In addition, we did evaluate the synergistic effect of PCA with 5-FU and OXA. Further, we determined the suppressive effects of different doses of PCA alone or in combination with 5-FU/OXA on cell proliferation after 24 and 48 hours. We identified a suppressive effect of PCA on cell viability at 48 h starting from the dose of 50 mu M Matrix metalloproteinase-2 (MMP-2) and MMP-9 gene expression levels and apoptotic effects showed significant increases and decreases depending on the dose and time applied in the experimental groups. The highest synergistic activity was seen at 2:1 concentration of 5-FU+ PCA. Our findings indicate the presence of the cytotoxic and apoptotic effects of PCA in Caco-2 cells at 48 h, increasing with a dose-and time-dependent manner.Öğe Prevalence of Accessory Renal Artery In Aortic Aneurysms(2020) Etli, Mustafa; Avnioglu, Seda; Dikici, RumeysaIntroduction: Open surgical procedures and endovascular aortic procedures are the most fearedrenal injuries in abdominal aortic surgery. The presence of renal anomalies and clear localization during aneurysm repair brings surgical success. In this article, we aimed to show the importance of renal anomalies in terms of mortality and morbidity in aneurysm repair.Materials and Methods: Between January 2017 and January 2019, 250 patients with aortic aneurysm and CT angiography were included in the study.The files of the patients who underwent computerized contrast angiographyforaorticaneurysmin Trainingand Research Hospital were reviewed retrospectively. Results: Bilateral renal artery was detected in four male patients; and left accessory renal artery was detected in five male and three female patients. At the end of the study, 250 patients were screened; and bilateral renal arteries were detected in 1.6%, left accessory arteries were detected in 3.2% of the eight patients.Conclusions: Itisimportantthatsurgeonsand radiologists know the accessory arterial variations not only in abdominal aortic surgery, but also in recent years duetoincreased renaltransplantation reconstruction, urological and radiological surgical techniques.Öğe Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method(Lippincott Williams & Wilkins, 2021) Avnioglu, Seda; Velioglu, Halil Aziz; Cankaya, Seyda; Yulug, BurakBackground Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are controversial findings regarding these volume alterations in MDD indicating even to increased volumes in some specific regions in MDD patients. Methods This study is a case-controlled study including 23 depression patients and 15 healthy subject person and 20-38 years of age, who have been treated at the Neurology and Psychiatry Department here. We compared specific anatomic regions between drug-free MDD patients and control group through MRI-Cloud, which is a novel brain imaging method that enables to analyze multiple brain regions simultaneously. Results We have found that frontal, temporal, and parietal hemispheric volumes and middle frontal gyrus, inferior frontal gyrus, superior parietal gyrus, cingulum-hippocampus, lateral fronto-orbital gyrus, superior temporal gyrus, superior temporal white matter, middle temporal gyrus subanatomic regions were significantly reduced bilaterally in MDD patients compared to the control group, while striatum, amygdala, putamen, and nucleus accumbens bilaterally increased in MDD group compared to the control group suggesting that besides the heterogeneity among studies, also comorbid factors such as anxiety and different personal traits could be responsible for these discrepant results. Conclusion Our study gives a strong message that depression is associated with altered structural brain volumes, especially, in drug-free and first-episode MDD patients who present with similar duration and severity of depression while the role of demographic and comorbid risk factors should not be neglected.Öğe Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: opposite sides of the same coin(Elsevier, 2022) Naureen, Humaira; Avnioglu, Seda; Yilmaz, Seher; Youssef, Lara; Farooqi, Ammad AhmadDiscovery of kisspeptin signaling has paradigmatically shifted our understanding about the instrumental role of transduction cascades in myriad of biological activities. Moreover, rapidly emerging evidence about central role of kisspeptin signaling in carcinogenesis and metastasis has attracted widespread attention. However, kisspeptin-driven signaling has been shown to dualistically regulate carcinogenesis and metastasis. In this chapter, we have summarized recent refinements in our knowledge about diametrically opposite roles of kisspeptin-mediated signaling in metastasis. Together, this progress has expanded the list of downstream effectors of kisspeptin-driven signaling. Major outstanding questions in the field include how kisspeptin-driven signaling crosstalks with different signaling pathways to regulate carcinogenesis and metastasis. © 2022 Elsevier Inc. All rights reserved.Öğe The effect of antioxidants in Ehrlich Ascites Cancer(Cellular and Molecular Biology Association, 2021) Yilmaz, Seher; Tokpınar, Adem; Eroğlu, Ece; Ates, Şükrü; Zahid, Rabbia; Avnioglu, Seda; Bozkurt, ÖzlemA fundamental goal in molecular oncology is to unravel the underlying mechanisms which cause the cell transformation. In line with this approach, genome-wide functional screening approaches have revealed exciting insights into heterogeneous nature of cancer. Rapidly expanding horizons of research have unraveled myriad of pathways which play instrumental role in carcinogenesis and metastasis. Oxidative stress has also been reported to be significantly involved in cancer onset and progression. In line with this approach, oxidative stress modulating chemicals have always been sharply divided into antioxidants and oxidative stress-inducing agents. Conceptual and experimental advancements have enabled us to critically analyze full potential of these two different groups of chemicals in cancer chemoprevention. Different antioxidants are currently being analyzed in different phases of clinical trials. Although it has been reported in the literature that antioxidant supplements reduce tumor cells in some tumors or cause volume reduction in solid tumor sizes, there is no definite consensus. Therefore, an antioxidant supplement guideline based on more detailed clinical research and as a result of these is needed to achieve the best care for cancer patients and to avoid risky treatments for cancer patients. © 2021 Cellular and Molecular Biology Association. All rights reserved.
