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Öğe 3D modeling and comparative analysis of the double arcus aorta case(2022) Avnioğlu, Seda; Dikici, Rümeysa; Etli, MustafaWe analyzed the double arch of a 51-year-old male patient who applied to the outpatient clinic with chest pain and shortness of breath and compared this rare case with the studies in the literature. Double aortic arch (DAA) is defned as a type of vascular ring malformation. The incidence of congenital heart diseases is less than 1%. DAA makes up 46–76% of all rings. We aimed to contribute to cardiac surgery by examining and modeling the diameters in the 2D and 3D images of the patient. For 3D modeling, an open-source software program ITK-SNAP 3.8 was used, which converts 2D images from MRI, CT, and ultrasound to 3D medical image volumes. CT images of the case taken from the SECTRA system of our hospital were uploaded to ITK-SNAP and segmentation was performed. With 3D modeling, a better understanding of the stenosis in the trachea and the double arch was achieved. The ascending aorta diameter was 30 mm. There were atherosclerotic changes in the aorta and its branches. The diameter of the right aortic arch was 22.2 mm, and the diameter of the left aortic arch was 14.5 mm. Trachea diameter was found to be 17 mm/13.2 mm. Esophageal diameter was 9.8 mm. The patient had no specifc complaints and no medical or surgical treatment was recommended because his physical examination was normal. We think that a better understanding of such cases in 3D may contribute to cardiovascular surgeryÖğe Does race have a role in the effect of fingerprint on gender?(2021) Avnioğlu, Seda; Dikici, Rumeysa; Yılmaz, HalilAim: Fingerprint is one of the personal and reliable physical features. The fingerprint has an important role in forensics, and it is used in the detection of criminals and identity checks. Studies on different races have been conducted, but no interracial comparison has been found in the literature. In this study, we have investigated the effect of race on finger ridge using the same method on 5 different races. Methods: In our study, the right thumb prints of 355 (148 female, 207 male) students aged 17-25 years in our school were taken with an ink pad (stamp) and recorded along with their ages, sexes, and races. Data were analysed by sex and race. Results: In the comparison by sex, the finger ridge counts of male (11.94±2.08) and female (12.76±2.02) participants were found to be statistically significantly different (p<0.001). Participants were classified as Turkish, Arab, Russian, Turkmen, and African. The difference in finger ridge counts between Turkish-Africans was found to be statistically significant in the comparison by races (p<0.05). Conclusion: Comparison of finger ridge counts by sex has been studied on many races, but each study has been conducted with a different method. In our study, we aimed to contribute to the literature by examining how the finger ridge counts of men and women differ in 5 different races by using the same method. Although the data we obtained are compatible with the literature for the Turkish race, there are differences for other races.Öğe Effect of decompressive surgery on spine balance in congenital lumbar kyphoscoliosis: anatomical aspect with a case report(2018) Köksal, Vaner; Avnioğlu, SedaThe lumbar vertebral column is a complex structure formed by the fusion of intervertebral joints. It protects the spinal cord by wrapping around it, carries most of the body’s weight and creates a flexible structure for the body. As individuals with congenital deformities of the lumbar vertebral column age, they develop some changes in the anatomy of the spine and with some consequences. In this case, a 35-year-old male patient had a deteriorated posture together with back pain since childhood. He had walking difficulty and numbness in two legs during walking for the last three years. He fell due to a sudden brake while he was travelling afoot by bus in 2015. He was admitted to the emergency service with loss of strength in two legs. Lumbar CT and MRI showed a severe narrowing of the spinal canal due to lumbar kyphoscoliosis. The patient had neurological deficits after hyperflexion trauma. The patient underwent emergency decompressive surgery due to marked paraparesis and narrow spinal canal. At the end of the first post-operative month, his clinical complaints were almost completely resolved, and his biomechanical balance did not show radiological deterioration. While the anatomical change that occurred during the natural course of congenital kyphoscoliosis increased the stability of the lumbar spine, it severely narrowed the spinal canal and affected the spinal nerves and thereby caused severe neurological deficits.Öğe Effects of paracetamol on vascular endothelial growth factor, sclerostin and FETUIN-A in the liver of rat fetuses(Alanya Alaaddin Keykubat Üniversitesi, 2020) Yılmaz, Seher; Göçmen, Yeşim; Tokpınar, Adem; Uçar, İlyas; Ateş, Şükrü; Avnioğlu, Seda; Nisari, MehtapAim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (?2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p<0.05).Conclusions: As a result, it is seen that the use of high doses of paracetamol in pregnancy causes changes in the liver and many biochemical values on the fetus. We think that an overdosing of paracetamol, which is sold without prescription and used as an innocent analgesic during pregnancy, should be examined and this study will be a reference for other studies to be conducted.Öğe Hypertrophy of the transverse ligament caused by os odontoideum: a case report(2017) Avnioğlu, Seda; Köksal, Vaner; Ertekin, TolgaOs odontoideum is a small oval or round shaped bone fragment observed as the most common congenital anomaly of theodontoid process. Since it causes a slowly increasing mobility or instability in the atlanto-axial joint, sudden death, tetraplegia, chronic neck pain, headache, torticollis and myelopathy may develop. The spinal canal widens initially at the craniocervical junction and symptoms can occur at a very late stage. In this case, clinical complaints emerged after the age of 35.There was no other neurological finding and no history of recent trauma in this case presenting with severe neck pain. Thiscase report shows how ligaments, the supporting connective tissue elements, can be thickened to maintain stability whenthe stability of the cervical spine is impaired. Since it may cause sudden death even when asymptomatic, it is important torecognize this pathology and to distinguish os odontoideum from odontoid fractures in trauma patientsÖğe İNFLAMATUAR AĞRI MODELİNDE PLATİN-MELOKSİKAM METAL KOMPLEKSİNİN ANTİ-HİPERNOSİSEPTİF ETKİLERİ(Kahramanmaras Sutcu Imam University, 2017) Yaman, Selma; Avnioğlu, Seda; Küçük, Kübra; Alakuş, Derya; Demirci, Büşra Nur; Muslu, Harun; Gölcü, AyşegülÖZET Amaç: Günümüzde, organik veya inorganik elementleri içeren birçok molekül ve makromolekül kompleksleri tıp ve ilgili araştırmalara konu edilmektedir. Bazı platin (Pt) komplekslerinin kanser tedavisinde kullanılması ile ilgili araştırmalar bu bileşiklere olan ilgiyi daha da arttırmıştır. Bu çalışmada klinik uygulamalarda romatoid artrit, osteo artrit ve miyalji gibi kas ve iskelet sistemine bağlı ağrı ve İnflamasyonlu durumlarda tercih edilebilen bir non-streoid olan Meloksikam (MLX)’ın, platin (Pt) ile oluşturulacak kompleksinin (MLX+Pt) inflamasyon modelinde araştırılması ve bu kompleksin etki mekanizmalarına yönelik yeni sonuçların elde edilmesi amaçlandı. Gereç ve yöntemler: Sağlıklı ve inflamatuar ağrılı (carrageenan (CAR) kullanılarak) sıçanların duysal fonksiyonları termal plantar test (hiperaljezi için), dinamik plantar aesthesiometer (allodini için) kullanılarak intraplantar olarak uygulanan ilaçların anti-hipernosiseptif etkileri, pençe kütleleri ölçülerek de anti-ödem etkileri değerlendirildi. Bulgular: MLX ve onun Pt kompleksi sağlıklı sıçanlarda doza ve zamana bağlı olarak anlamlı anti nosiseptif etkiler oluşturdu. CAR uygulaması sıçanların pençesinde zaman bağlı olarak gelişen hiperaljezi, allodini ve ödem gibi inflamatuar yanıtlar ortaya çıkardı. MLX ve MLX+Pt kompleksi ortaya çıkan hipernosiseptif etkileri zamana ve doza bağlı olarak baskıladı. İnflamasyonlu grupta eşik ve latans değerlerindeki uzatıcı etkiler çok daha fazlaydı. Pt kompleksi MLX’e göre daha etkili anti-nosiseptif ve anti-hipernosiseptif etkiler meydana getirdi. Benzer şekilde pençe kütlesindeki artış MLX+Pt tarafından daha fazla baskılandı. Sonuç: Elde edilen veriler, hem MLX hem de MLX+Pt kompleksinin hiperaljezi ve allodini gelişimini engellemesi bu ilaçların lokal analjezik özelliğini göstermektedir. Pt kompleksi MLX’in analjezik ve anti-inflamatuar etkilerini artırması bu tür bileşiklerin etki mekanizmalarının belirlenmesine yönelik yeni çalışmalara ilgiyi artırabilir.Öğe Investigation of the correlation between cardiac parameters and aortic diameter in patients with ascending aortic aneurysm(2022) Etli, Mustafa; Avnioğlu, Seda; Yılmaz, Halil; Karahan, OğuzBackground: Aortic aneurysms (AA) are enlargement of the aorta silently until diagnosing, not detectable on physical examination, and usually incidentally discovered during radiologic scanning for other reasons. It can get bigger sizes and can result in life-threatening outcomes if not detected early on. In this study, we aimed to determine the relationship between ascending aortic diameter and cardiac parameters that can be detected with tomography or/and echocardiography. Newly diagnosed (n: 85) ascending AA patients and healthy individuals (n: 86) who have not any thoracic pathology in computed tomography (CT) scans included to the study. Echocardiographically determined left atrial dimension (LAD), left ventricular end-diastolic diameter (LVDd), left ventricular end-systolic diameter (LVDs), left ventricular ejection fraction (LVEF) and the left ventricular posterior wall thickness (LVPWd) values of each patient were recorded. The thorax diameters, ascending aorta diameters and cardiac volume values recorded from CT scans. The obtained findings were statistically compared. Results: Positive correlation was found between aortic diameter and aging (p: 0.000). Increased thorax diameter and cardiac volume values were detected in ascending AA cases (p < 0.05). It was found to be ascending aortic diameter was positively correlated with thorax diameter and cardiac volume (0.50 < r ? 0.70) values and higher aortic diameter, cardiac volume, thorax diameter values were detected in male individuals when compared with the female gender. There was no significant correlation between LVEF, LVDd, and LVDs values and aortic diameter. Conclusions: Cardiac volume and thorax diameter were found as strongly correlated with the diameter of the ascending aorta. The clarifying of these parameters with larger cohorts might be beneficial for the estimation of the progression of ascending AA.Öğe Is there effect of intervertebral disc herniation on the lumbar spine in early period? A morphometric and stereological study(Universidad de la Frontera, 2020) Köksal, Vaner; Avnioğlu, Seda; Atay, EmreThe degeneration of the Lumbar Intervertebral Disc (LIVD) and the other elements of the spine are an inevitable result of aging. However, it is observed that the same degree of degenerative change does not occur in each individual. In the present study, the purpose was to compare the morphometric changes on the lumbar spine with or without intervertebral disc herniation in early period. Group 1 (the Patient Group) consisted of the patients who were diagnosed with lumbar intervertebral disc hernia and who were not operated at least one month clinical duration. Group 2 (the Control Group) consisted of individuals who were selected randomly, had only back pain, underwent magnetic resonance imaging (MRI), and were determined to have intact intervertebral disc. The sagittal and axial MRI sections of lumbar spine was used for measurements and statistical evaluation. There were no statistically significant differences between the intervertebral disc volumes, vertebral body volumes and intervertebral disc anterior and posterior heights of Group 1 and 2 (p>0.05). In terms of anterior-posterior length, the length of the L5 vertebral body was determined to be more in the Patient Group (p<0.05). A correlation was determined in terms of the increase in L2, L4 and L5 volumes with increasing age; however, there were no statistically significant correlations between age increase and a decrease in the intervertebral disc volumes. There were no correlations between the increase in age and the decrease in intervertebral disc heights (p>0.05). There were no apparent relations between the change on the lumbar vertebra corpus and intervertebral disc in early period. It was concluded that the intact intervertebral disc could protect the lower lumbar vertebra corpus from degenerative changes. Although the herniation of the intervertebral disc is newly formed, it is understood that the physiological process or morphometric changes started earlier. © 2020, Universidad de la Frontera. All rights reserved.Öğe Koksidinialı Hastalarda koksiksin morfometrik değerlendirilmesi ve sınıflandırması(Alanya Alaaddin Keykubat Üniversitesi, 2020) Özkal, Birol; Avnioğlu, Seda; Candan, BüşraAmaç: Koksidinalı hastalarda morfolojik ve patolojik anatominin özellikleri sınıflandırmayı amaçladık.Hastalar ve yöntem: Nisan 2015 - Nisan 2018 tarihleri arasında Alanya Alaaddin Keykubat Üniversitesi Eğitim Araştırma Hastanesine koksidina yakınması ile başvuran 16 yaş ve üzerindeki hastalar çalışmaya dahil edildi. Hastaların oturarak ve ayakta çekilen koksiks ve ön-arka pelvis grafileri retrospektif olarak incelendi.Bulgular: Koksiksin skolyozunun, hipermobilitesinin ve dislokasyonunun sakrokoksigeal açılanma ile ilişkili olmadığı görüldü. Hastaların oturarak ve ayakta çekilen koksiks grafi ölçümlerinde sakrokoksigeal ve interkoksigeal açıları arasında pozitif yönlü anlamlı bir ilişki bulundu. Ameliyat olmamış hastalarda sakrum ve koksiks uzunluğu arasında ve interkoksigeal açı ve koksiks uzunluğu arasında ilişki bulundu. Erkeklerde sakrokoksigeal eklem uzunluğu ile sakrokoksigeal açı ilişkili bulundu. Kadınlarda sakrokoksigeal eklemde füzyonun daha düşük olduğu tespit edildi. Sonuç: Koksidina yakınması ile gelen hastalar değerlendirilirken koksiksin tüm düzlemlerde hareket edebilen ve patoloji geliştirebilen bir omurga segmenti olduğu unutulmamalıdır. Bu hastaların yan ve AP pozisyonda oturarak ve ayakta çekilen dinamik direkt grafilerle değerlendirilmesi patolojinin bulunmasında etkili bir yöntemdir. Koksidinalı hastalarının sınıflandırılmasında her üç düzlemde patoloji içeren yeni sınıflandırma gereklidir. Sınıflandırmamızın bu eksikliği gidereceğini düşünmekteyiz.Öğe Regulation of signaling pathways by Ampelopsin (Dihydromyricetin) in different cancers: Exploring the highways and byways less travelled(C M B Assoc, 2019) Fayyaz, Sundas; Qureshi, Muhammad Zahid; Alhewairini, Saleh S.; Avnioğlu, Seda; Attar, Rukset; Sabitaliyevich, Uteuliyev Yerzhan; Pawlak-Adamska, EdytaAmpelopsin or Dihydromyricetin is gradually emerging as a high-quality natural product because of its ability to modulate wide-ranging signaling pathways. Ampelopsin (Dihydromyricetin) has been reported to effectively modulate growth factor receptor (VEGFR2 and PDGFR beta) mediated signaling, TRAIL/TRAIL-R pathway, JAK/STAT and mTOR-driven signaling in different cancers. Ampelopsin (Dihydromyricetin) has also been shown to exert inhibitory effects on the versatile regulators which trigger EMT (Epithelial-to-Mesenchymal Transition). Findings obtained from in-vitro studies are encouraging and there is a need to comprehensively analyze how Ampelopsin (Dihydromyricetin) inhibits tumor growth in different cancer models. Better knowledge of efficacy of Ampelopsin (Dihydromyricetin) in tumor bearing mice will be helpful in maximizing its translational potential.Öğe Sağlık Yüksekokulu öğrencilerinin eleştirel düşünme eğilimleri(2019) Oktay, Ayşe Aslı; Taş, Filiz; Doğaner, Adem; Gülpak, Merve; Avnioğlu, SedaAmaç: Bu çalışmanın amacı hemşirelik öğrencilerinin eleştirel düşünme eğilimlerini ve etkileyen faktörleri incelemektir. Gereç ve Yöntem: Tanımlayıcı tipte yapılan araştırmanın evrenini; Kahramanmaraş Sütçü İmam Üniversitesi Kahramanmaraş Sağlık Yüksekokulu’nda eğitim gören ebelik ve hemşirelik öğrencileri (n=640) oluşturmuştur. Araştırmaya ebelik bölümünden 210, hemşirelik bölümünden 291, toplam 501 öğrenci katılmıştır. Veriler, “Sosyo-demografik Özelliklerini” içeren veri formu ve “Kalifornia Eleştirel Düşünme Eğilimi Ölçeği” kullanılarak araştırmacılar tarafından toplanmıştır. Bulgular: Eleştirel Düşünme Eğilimi Ölçeği toplam puan ortalaması 247.37±22.3 olarak belirlenmiştir. Ebelik ve hemşirelik bölümleri arasındaki toplam puan ortalamaları farkı istatistiksel olarak karşılaştırıldığında anlamlı fark olmadığı belirlenmiştir. Ayrıca cinsiyet, okuduğu bölüm, okuduğu sınıf ve sosyal aktivitelere katılmanın eleştirel düşünme alt boyutlarını; kişilik yapısı özelliklerinin ise toplam eleştirel düşünme eğilimlerini olumlu yönde etkilediği saptanmıştır. Sonuç: Araştırıcı ve dürüst karaktere sahip olmanın eleştirel düşünme eğilimleri üzerinde etkili olduğu, sosyal aktivitelere katılmanın kendine güven ve meraklılık boyutlarında eleştirel düşünme eğilimlerini yükselttiği sonucuna varılmıştırÖğe Stereological measurement of liver volume in newborn cadavers(2020) Avnioğlu, Seda; Unur, Erdoğan; Acer, Niyazi; Ertekin, Tolga; Doğaner, AdemPurpose: The aim of our study was to compare different techniques for the estimation of liver volume using cadaveric sample, magnetic resonance imaging (MRI) and ultrasonography (USG) images, and to measure errors associated with volume estimation techniques based on fluid displacement (the Archimedes' principle). Materials and Methods: Our study was formed of five newborn cadavers aged 39.7±1.5 weeks and weighted 2.220±1.056 g. We used three different methods for calculate the liver volume. Results: Liver volume (LV) measured by the Archimedes' principle was 70.00±49.96 cm3. There was no significant difference between the methods. Conclusion: MR and USG images provide easy, applicable and reproducible estimates in calculating volume of normal and anomalous liver with the Cavalieri’s principle. We think that our study may be a reference for similar studies to be done in the upcoming years.Öğe The effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model(2022) Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakaris, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, BurakObjectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
