Yazar "Aslan, F." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Cerebral volume alterations in late-onset monocular blindness-a volumetric imaging study
    (Czech Medical Soc, 2023) Oktem, E. O.; Aslan, F.; Ozen, O.
    Aim: An increasing number of studies have demonstrated that persons who are blind from birth may have some alterations in the brain, although the neuroanatomical and functional effects of late-onset monocular blindness (LMB) are not well known. In our study, we aimed to measure the volumes of cerebral structures in LMB individuals and compare with healthy subjects, in order to investigate the underlying neuro-adaptive mechanisms. Material and methods: A study group with 13 LMB patients due to an isolated ocular trauma and a control group with the 13 age- and sexmatched healthy individuals were evaluated. All participants underwent a full ophthalmological examination. Brain MRI examination of the participants was performed using a 1.5-T MRI device and volumetric data were analyzed through the MRIvolBrain and MRICloud procedures. Results: Compared with healthy controls, individuals with LMB showed significantly increased accumbens volumes and decreased volumes of the middle occipital gyrus and cuneus (Cu). In the statistical analysis between the blind eyes and sighted eyes of LMB individuals, the ratio of cornu ammonis to the intracranial cavity and Cu volumes were low on the blind side. In a comparison of cerebral volumes on the sighted side of the LMB group and ipsilateral cerebral volumes of controls, we found lower supramarginal gyrus volumes, higher subiculum volumes in the LMB group than in the control group. Conclusion: LMB may lead to structural alterations in specifi c brain regions, such as the limbic system and visual cortex, which play a potential role in neuro-adaptive mechanisms.
  • [ X ]
    Öğe
    The role of temperament in evaluating the relationship between symptoms and signs in dry eye disease
    (Masson Editeur, 2023) Kuru, T.; Oktem, C.; Oktem, E. O.; Aslan, F.
    Objectives. - In this study, we aimed to evaluate the relationship between symptoms and objective findings and dry eye (DE) patients' personalities and levels of depression and anxiety. Methods. - The study group consisted of 67 DE patients who presented to the ophthalmology clinic with symptoms of dry eye disease (DED) and were first diagnosed. Patients underwent a complete ophthalmologic examination, including tear-film break-up time (TBUT), Schirmer 1 and Ocular Surface Disease Index (OSDI). All subjects also completed the Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results. - No relationship was found for the Schirmer 1 Test and TBUT with psychological parameters or OSDI scores. When compared with the normal values for the Turkish population, sub-dimensions of temperament in DED; novelty seeking (NS) was significantly lower (P < 0.001); harm avoidance (HA) (P = 0.014), and persistence (P < 0.001) were significantly higher. Signifi-cant positive correlation with HA and significant negative correlation with NS were found for the OSDI results. Furthermore, our mediation model revealed that anxiety mediated the effect of NS and HA on OSDI. Conclusion. - The significant association of temperament sub-dimensions with OSDI scores in the DED group may play a role in explaining the inconsistency between symptoms and signs. Professionals who care for DED should consider temperament sub-dimensions when they detect discordance between symptoms and signs. 0 2023 Elsevier Masson SAS. All rights reserved.