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    Is calprotectin a reliable marker in surgical ICU settings? A clinical evaluation of its role in sepsis and mortality prediction
    (Frontiers Media Sa, 2025) Aladag, Ebru; Zora, Muhammed Emin; Gultekin, Yucel; Mizrak, Soycan
    Background: Calprotectin, a neutrophil-derived protein, has emerged as a potential biomarker for inflammation and infection. This study evaluated the utility of serum calprotectin levels in diagnosing sepsis and predicting mortality in surgical intensive care unit (ICU) patients. Methods: This prospective observational study included 124 patients admitted to the surgical ICU at U & scedil;ak Training and Research Hospital between 2022 and 2024. Data on demographics, serum calprotectin, CRP, PCT, lactate levels, and clinical scores (SOFA, APACHE II) were collected. ROC analysis was used for predictive accuracy; Spearman and Pearson correlation coefficients assessed associations. Results: No significant associations were found between serum calprotectin and SOFA/APACHE II scores, CRP, or lactate. However, calprotectin correlated positively with PCT in sepsis (r = 0.428, p = 0.002) negatively in postoperative subgroups (r = -0.48, p < 0.001). Calprotectin showed poor prognostic accuracy (AUC = 0.472). Mortality was significantly associated with high CRP and severity scores, but not with calprotectin levels. Conclusion: Calprotectin alone lacks sufficient diagnostic or prognostic power for sepsis in surgical ICU patients. It may serve as a complementary marker alongside PCT in specific subgroups.
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    Visualization Analysis of Transversus Abdominis Plane Block in Abdominal Surgery Based on Bibliometrics
    (2024) Aladag, Ebru; Yılmaz, Habip; Erdoğan, Erhan
    Background: Acute pain following surgery is common and constitutes a significant healthcare priority because of its potential impact on quality of life. The use of transversus abdominal plane block (TAP-B) has emerged as a current approach to alleviate postoperative pain. This study was designed to (a) assess the scientific trends in the use of TAP-B and (b) determine the trend toward the decision to use TAP-B, especially when central neuraxial blocks are technically difficult or contraindicated. Materials and Methods: This study examines TAP-B research from a bibliometric perspective. As of June 12, 2023, the literature related to TAP-B published in the last two decades (2003-2023) was retrieved from the Web of Science Core Collection database. The keywords “transversus abdominis plane” and “abdominal” were used for the search strategy. Data analysis and visualizations were conducted using VOSviewer 1.6.0. Results: A total of 546 studies were examined, with the year 2021 (n=1491) receiving the highest number of citations and 2022 (n=56) being the most productive year in terms of publications. The first publication in 2007, authored by McDonnell JG. from Ireland, had the highest publication frequency (n=9) and citations (n=498). Conclusion: Studies in the literature indicate an increasing trend in the use of TAP-B for postoperative pain management after lower abdominal surgery, which emphasizes its efficacy. The TAP block is emerging as a cornerstone in postoperative multimodal analgesia in cases where central nerve blocks are contraindicated or technically difficult, especially where central neuraxial blocks are contraindicated or technically difficult.