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    Effects of vascularization when different alloplastic implant materials are used in adjacently with acellular dermal matrix
    (2025) Fariz, Sevin; Karagül, Meryem İlkay; Yilmaz, Sakir Necat; Asoğlu, Zehra Demiray; Şengül, Merve Türkegün
    Objective: Autologous tissue transplantation is the best way to repair tissue defects. Autologous graft materials can cause in the formation of scars and, in some cases, a reduction in the functionality of the donor site. This study aimed to ascertain how often revascularization in the acellular dermal matrix (ADM) is formed when different types of alloplastic implant materials are used in reconstructions. Method: The Wistar albino rats were assigned to three groups (n=7): various alloplastic materials (porous polyethylene, titanium, tricalcium phosphate, silicone), coated with ADM, were placed in distinct subcutaneous pockets on the thoracodorsal region of the rats, at 7, 14, and 21 days post-procedure, the rats were sacrificed for sampling. Sections were stained with hematoxylin-eosin. The degree of revascularization was assessed through the use of immunohistochemical labelling (anti-CD105 antibody). Results: The results indicated that minimal revascularization was observed on day 7, while significantly increased revascularization was evident on days 14 and 21. The use of alloplastic materials showed a significant increase in the number of CD105-positive vessels on days 7, 14 and 21. There was an increase in the number of CD105-positive vessels on day 21 compared to day 7. There was no significant difference in the number of CD105-positive vessels between days 7 and 14 in the tricalcium phosphate and silicone groups. Conclusion: The study concluded that distinct alloplastic implants used adjacent to ADM have no negative impact on revascularization rates. This is the most sought-after objective in the field of soft tissue reconstruction.
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    Investigation of Tobacco and Tobacco Product Use and Nicotine Dependence Level of Physicians
    (2025) Sarıkan, İsmail; Tüter, Sibel; Şengül, Merve Türkegün
    Aim: The World Health Organization called tobacco use a \"tobacco epidemic\" and identified it as the number one preventable cause of death. This study aimed to investigate the tobacco product use and dependence levels of physicians who are role models for society. Methods: The study was conducted with physicians working at Alanya Research and Training Hospital using an online survey between March and September 2024. Sociodemographic data, tobacco product use status, nicotine dependence levels, and attitudes toward quitting smoking among physicians were questioned. Their dependence levels were measured with the Fagerstrom Test for Nicotine Dependence. Results: A total of 218 physicians participated in the study, 61.5% of whom were male, and 38.5% were female. While 63.30% of the participants were under the age of 40, 51.4% were married, and 48.6% were single. The rate of men using tobacco products (37.6%) was higher than that of women (13.3%). The difference between the rates of men (25.5%) and women (64.3%) who quit tobacco products was statistically significant. The relationship between marital status and tobacco product use was statistically significant (p=0.039). Nicotine dependence levels were higher in the participants over 50 years of age than in those under 30 years of age. Conclusion: The tobacco product use frequency of the physicians who participated in this study was similar to the frequency in the general population. Raising awareness among physicians about the harms of tobacco use before and after their graduation may contribute to reducing their frequency of tobacco product use.
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    Retrospective Analysis of Treatment Selection, Radiological Outcomes, and Complications in Distal Radius Fractures across Age Groups
    (Alanya Alaaddin Keykubat Üniversitesi, 2025) Dirlik, Günbay Noyan; Şengül, Merve Türkegün; Aksoy, Ahmet; Aslan, Ahmet
    Aim: To evaluate the effect of age on treatment selection, radiological outcomes, and complications in distal radius fractures. Materials and Methods: A total of 97 patients aged ?18 years with distal radius fractures treated between January and December 2020 were retrospectively reviewed and categorized into three age groups of 18–44, 45–64, and ?65 years. Conservative (splint/cast with or without closed reduction) and surgical (mostly, volar locking plate-screw) treatments were applied. Volar tilt, volar angulation, radial length, radial inclination, intra-articular step-off, and gap were measured at three time points. Results: Age groups were found to be significantly associated with treatment modality and the presence of complications (p
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    SİSTEMİK LUPUS ERİTEMATOZUS HASTALIĞINDA C-REAKTİF PROTEİN VE PENTRAKSİN-3 DÜZEYLERİNİN ARAŞTIRILMASI
    (2024) Aslantas, Sukran; Oruçoğlu, Nurdan; Şengül, Merve Türkegün; Fidancı, Senay Balcı; Tamer, Lülüfer
    Amaç: Sistemik lupus eritematozus, çoklu otoantijenlere karşı poliklonal otoimmüniteyi içeren ve çok çeşitli klinik belirti spektrumuna sahip, öngörülemeyen seyirli otoimmün bir hastalıktır. Otoimmün hastalıklarda, uzun pentraksin ailesinden olan pentraksin-3 seviyelerinin dolaşımda arttığı bulunmuştur. Pentraksin-3, diğer pentraksinlerden farklı olarak periferal dokularda yerleşik ve doğal bağışıklık hücreleri tarafından, inflamatuar sinyallere cevap olarak üretilir. Bu çalışmada, kronik enflamasyon ve immün fonksiyon bozukluğu ile karakterize olan sistemik lupus eritematozus’da, inflamatuar belirteçlerden C-reaktif protein ve pentraksin-3 düzeyleri arasındaki ilişkinin araştırılması amaçlandı. Yöntem: Çalışmaya, dahil edilme kriterlerine uyan, sistemik lupus eritematozus tanısı almış 56 hasta ve 55 sağlıklı birey dahil edildi. Tam kan sayımı, eritrosit sedimantasyon hızı, alanin transaminaz, kreatinin ve C-reaktif protein otoanalizörde çalışılırken; pentraksin-3 düzeyleri, serum örneklerinden, ELISA yöntemi ile çalışıldı. Bulgular: Çalışma verileri incelendiğinde, sistemik lupus eritematozus hastalarında, C-reaktif protein ve pentraksin-3 düzeyleri kontrol grubuna göre anlamlı yüksek bulundu (sırasıyla p=0,003; p=0,008). Pentraksin-3 ile diğer parametrelerin, grup içi düzeylerinin korelasyonu değerlendirildiğinde istatistiksel olarak anlamlı ilişki bulunmadı. Sonuç: Sistemik lupus eritematozus, farklı doku ve organ tutulumları olan ve buna bağlı olarak farklı klinik belirtilere yol açan bir hastalıktır. Aynı zamanda bu belirtilerin spektrumu da oldukça geniştir. Bu nedenle, sistemik lupus eritematozus ile ilişkilendirilmiş genetik yatkınlık doku ve organ tutulumları ve hastalığın şiddeti ve aktifliğine göre gruplandırma yaparak daha ileri çalışmalar önermekteyiz.
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    The Effect of Cluster Size for Model Performance in High-Dimensional Longitudinal Studies: A Simulation Study
    (2023) Şengül, Merve Türkegün; Tasdelen, Bahar; Yologlu, Saim
    Objective: In order to prevent model estimation er- rors and deviations in high-dimensional longitudinal studies, risk models are established through penalized methods. The aim of this study is to examine the effect of small cluster effects on the gener- alized estimating equations (GEE) and penalized GEE (PGEE) model performances in high-dimensional longitudinal data. Mate- rial and Methods: A simulation study was designed to compare the GEE and PGEE model performances, Type I error rates, and power in two-period longitudinal data structures with different clus- ter sizes (n=20, 30, 50, 100, 200), different numbers of predictors (p=10, 20, 50) and different correlation levels between predictors (r=0.20, 0.50, 0.80). Results: It was observed that the GEE coef- ficient estimates were misleading and inconsistent, the Type I error rates were high, and the power of the test was weak at insuf- ficient cluster sizes and high correlations between predictors. Even when the number of predictors and cluster size were in the balance (p=10, n=100, 200), Type I error rates were obtanied high for GEE. Increasing the cluster size was not enough to re- duce the Type I error rate of GEE. The PGEE produced more successful results than GEE in all conditions. The power of PGEE increased to over 80% in all scenarios. Conclusion: The PGEE yielded more consistent results by controlling the relationships both within the cluster and between the predictors. In high- dimensional longitudinal studies, it was observed that the use of PGEE is more effective than GEE.
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    The relationship between fall risk and depression, anxiety and quality of life in patients with osteoporosis
    (Balıkesir Üniversitesi, 2025) Hanbaba, Ünzüle; Sarıkaya, Pınar Müge; Güvener, Orhan; Şengül, Merve Türkegün; Biçer, Ali; Şahin, Günşah
    Introduction: In this study, in patients diagnosed with osteoporosis the relationship between fall risk and depression, anxiety and quality of life has been investigated. Methods: This study included 100 women with and without osteoporosis. The Morse Fall Scale(MFS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) and European Osteoporosis Society Quality of Life Survey (QUALEFFO) scale were applied. Results: The mean fall risk value was higher in patients with osteoporosis than in healthy controls and was statistically significant (p=0.005). In osteoporosis patients, there was a positive correlation all score (r=0.226, r=0.23, r=0.302, respectively). Conclusion :As a result, patients with osteoporosis had an increased risk of falling,depression and anxiety levels.There was no correlation between the risk of falling and depression and anxiety levels, but it was observed that the quality of life worsened with the increased risk of falling.