Yazar "Çankaya, Seyda" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Investigation of the effect of adalimumab on experimental brain injury in mice
    (Alanya Alaaddin Keykubat Üniversitesi, 2019) Günal, Mehmet Yalçın; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Şakul, Ayşe Arzu Sayın
    Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: To investigate the effects of adalimumab, we induced brain injury in mice using a cold trauma model and evaluated the underlying cell survival/ death mechanisms via cresyl violet and calculated infarct/edema volume with image analyze system. Results: Although our data indicated a tendency to decreased infarct and edema volume, these findings are not significant statistically. Conclusion: To the best of our knowledge, this is the first study evaluating the neuroprotective effect of adalimumab on injured neurons.
  • [ X ]
    Öğe
    Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice
    (2019) Gunal, Mehmet Yalcin; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Şakul, Ayşe Arzu Sayın
    Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that \"TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect\".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.