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Öğe A different view on the pathophysiology of Parkinson's disease: a descendent neurochemical hypothesis?(Wolters Kluwer Medknow Publications, 2019) Yuluğ, Burak; Ozansoy, Mehmet; Çankaya, Şeyda[No abstract available]Öğe A rare entity of acquired idiopathic generalised anhidrosis which has been successfully treated with pulse steroid therapy: Does the histopathology predict the treatment response?(Ifjusagi Lap-es Konyvkiado Vallalat, 2020) Öktem, Ece Özdemir; Çankaya, Şeyda; Uykur, Abdullah Burak; Erdem, Nazan Şimşek; Yuluğ, BurakAcquired idiopathic generalised anhidrosis is an uncommon sweating disorder characterized by loss of sweating in the absence of any neurologic, metabolic or sweat gland abnormalities. Although some possible immunological and structural mechanisms have been proposed for this rare entity, the definitive pathophysiology is still unclear. Despite some successfully treated cases with systemic corticosteroid application, the dose and route of steroid application are controversial. Here, we present a 41-yearold man with lack of generalised sweating who has been successfully treated with high dose pulse intravenous prednisolone. We have discussed his clinical and histopathological findings as well as the treatment options in view of the current literature. © 2020 Ifjusagi Lap-es Konyvkiado Vallalat. All rights reserved.Öğe Alzheimer Hastalığını Hafif Bilişsel Bozukluktan Ayırmak İçin Basit Bir MRI-Tabanlı Görsel Kılavuz(Kahramanmaraş Sütçü İmam Üniversitesi, 2023) Çankaya, ŞeydaAmaç: Bu çalışmada manyetik rezonans görüntülemede (MRI) hipokampus uzunluğunun görsel olarak değerlendirilmesi yoluyla hafif bilişsel bozukluk (HBB) ile Alzheimer hastalığı (AH) arasında ayrım yapmayı amaçladık. Gereç ve Yöntemler: HBB ve AH tanısı alan hastalar hastane bilgi yönetim sisteminden geriye dönük olarak tarandı. Hipokampus yüksekliğinde azalma olup olmaması ile hipokampal atrofinin tanımlanması MRI ile değerlendirildi. Hipokampusta yükseklik kaybı olan hastalar klinik araştırmacı tarafından AH olarak sınıflandırıldı ve hastaların tanıları sistem üzerinden daha sonra kontrol edildi. Bulgular: Çalışmaya AH (n=14) ve HBB (n=42) olan toplam 56 hasta dahil edildi. AH hastalarında HBB hastalarından anlamlı olarak daha fazla hipokam pal atrofi vardı (?2=6.222, SD=1, p=0.013). Sonuç: HBB ve AH arasındaki ayırıcı tanı kompleks bir konudur. MRI’a basit bir bakış, klinik rutinde hekime kısa bir fikir verebilir.Öğe Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial(2023) Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Tozlu, Özlem Özdemir; Arslan, Mehmet Enes; Hacımüftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Turkez, Hasan; Boren, Jan; Uhlen, Mathias; Mardinoğlu, AdilAbstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress. Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the efect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the frst 28 days and twice daily between day 28 and day 84. The primary endpoint was the diference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efcacy of the CMA in AD patients. Results We showed a signifcant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P=0.00001, 29% improvement) in the CMA group. Moreover, there was a signifcant decline (P=0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels ofÖğe Emotional Burdens and Cognitive Decline: the Role of Anxiety in Mild Cognitive Impairment(Kafkas Üniversitesi, 2025) Sayman, Ceyhun; Aylak, Uğur; Çankaya, Şeyda; Yuluğ, BurakAim: This study investigates the complex interactions between mild cognitive impairment (MCI), depression, and anxiety, focusing on how these factors affect cognitive function and progression risks. The goal is to inform early diagnostic strategies and targeted therapeutic interventions in individuals with MCI Matherial and Methods: This prospective study included 45 patients diagnosed with MCI (mean age: 66.1±7.7 years; 23 males [51%], 22 females [49%]) at a neurology outpatient clinic. Sociodemographic data, including education level and medical history, were collected. Cognitive and psychiatric assessments were conducted using the Montreal Cognitive Assessment (MoCA), Standardized Mini-Mental State Examination (SMMT), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Scale (HAS). Stratification was done according to anxiety severity, and comparisons were made across these groups on the cognitive performances. Results: Anxiety levels were significantly higher in females than males (p=0.001). While global MoCA and SMMT scores did not differ significantly by gender, males showed significantly better performance in verbal fluency (p=0.025) and a trend in abstract thinking (p=0.057). A significant decline in MoCA total scores was observed with increasing anxiety severity (p=0.024), with verbal fluency (p=0.011), abstract thinking (p=0.005), and attention (p=0.050) notably affected in the severe anxiety group. Conclusions: This study highlights anxiety as a key modifiable risk factor for cognitive impairment in MCI, with domain-specific deficits in executive function. Unlike depression, anxiety showed a stronger correlation with cognitive decline. These findings suggest that early identification and targeted treatment of anxiety in MCI could help delay progression to dementia and improve clinical outcomes.Öğe Hindistan Cevizi Yağının Travmatik Beyin Hasarı Olan Farelerde Nöroprotektif Etkisi(Kahramanmaras Sutcu Imam University, 2021) Çankaya, Şeyda; Günal, Mehmet Yalçın; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Özdemir, Ekrem Musa; Saatci, Özlem; Çankaya, BarışAmaç: Bu çalışmada hindistan cevizi yağının travmatik beyin hasarı olan farelerde olası nöroprotektif etkisini değerlendirmeyi amaçladık. Materyal ve Metod: Fareler rastgele iki gruba ayrıldı (grup başına n = 5); diğer bir deyişle, kontrol ve Hindistan cevizi yağı grubu; sırasıyla soğuk beyin hasarından önce bir hafta boyunca 250 ul salin ve her bir os hindistancevizi yağı başına 10 mg / kg vücut ağırlığına göre belirlendi. Beyindeki enfarktüs ve ödem hacmi yaralanmadan 24 saat sonra sekizinci günde iki grupta Kresil Moru ile ölçüldü. Bulgular: Verilerimiz, hindistancevizi yağı uygulamasından sonra enfarktüs ve ödem hacimlerinde istatistiksel olarak anlamlı bir düşüş olduğunu gösterdi. Sonuç: Bulgularımız, hindistancevizi yağının farelerde travmatik beyin hasarı sonrası hasarlı nöronlar üzerinde potansiyel bir nöroprotektif etkiye sahip olduğunu desteklemiştir.Öğe Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy(Bentham Science Publ Ltd, 2020) Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Ozansoy, Muzaffer; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, ErtuğrulBackground: Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. In this respect, there are no cases of successful clinical application of such candidate molecules when it comes to human patients. Methods: After 24 hours of culturing, three different minocycline (Sigma-Aldrich, M9511, Germany) concentrations (1 mu M, 10 mu M and 100 mu M) were added to the primary cortical neurons 15 minutes before laser axotomy procedure in order to observe protective effect of minocycline in these dosages. Results: Here, we have shown that minocycline exerted a significant neuroprotective effect at 1 and 100 mu M doses. Beyond confirming the neuroprotective effect of minocycline in a more standardised and advanced in-vitro trauma model, our findings could have important implications for future studies that concentrate on the translational block between animal and human studies. Conclusion: Such sophisticated approaches might also help to conquer the influence of humanmade variabilities in critical experimental injury models. To the best of our knowledge, this is the first study showing that minocycline increases in-vitro neuronal cell survival after laser-axotomy.Öğe More evidence for headache and spontaneous glabellar ecchymosis: Does the headache type or the treatment response matter? A neurovascular hypothesis(Wiley, 2019) Yuluğ, Burak; Işık, Doğan; Çankaya, Şeyda; Öktem, Ece O.; Hanoğlu, Lütfü[No abstract available]Öğe Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates(Elsevier Sci Ltd, 2020) Çankaya, Şeyda; Öktem, Ece Özdemir; Saatçi, Özlem; Vehoğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşeka, Ahmet; Yuluğ, BurakIntroduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and headache patients after paracetamol treatment. Material and methods: The study group included 16 patients with tension-type headache, and 12 healthy age-and sex-matched controls. After a detailed neurological examination Positive and Negative Affect Schedule (PANAS) and Empathy for Pain Scale (EPS) were applied to all subjects. Next, 1000 mg paracetamol tablet was administered orally, after administration of paracetamol, EPS were repeated, and fMRI was performed to all subjects. Results: We have revealed increased empathy scores in the headache group after the paracetamol treatment which were associated with significant alterations in brain regions which play a critical role in the processing of empathy. Discussion: The observed neuroimaging and clinical difference between healthy and headache subjects could be related to the fact that pain perception in healthy subjects might differ in some aspects from the mechanisms of empathy in headache-experienced patients. Conclusion: To the best of our knowledge, this is the first study that evaluated the paracetamol treatment and neural networks' correlation with pain empathy in healthy and headache individuals. (C) 2020 Elsevier Ltd. All rights reserved.Öğe Parkinson Hastalarında Motor Olmayan Bulguların NMSQ Anketi Kullanılarak Değerlendirilmesi(İnönü Üniversitesi, 2020) Çankaya, Şeyda; Altınayar, Sibelİdiyopatik Parkinson Hastalığı (IPH) sık görülen bir hareket bozukluğudur. Hastaların özürlülüğüne motor belirtiler kadar, motor olmayan belirtiler de yol açar. Motor olmayan belirtiler (MOB) Parkinson hastalarında %88 oranında görülür. Bu semptomlar, hastaların yaşam kalitesinin bozulmasında önemli rol oynar. Hastaların modern ve özenli sağlık bakımlarına ulaşabilmesi için MOB’in tanınması ve tedavisi çok önemlidir. Bu nedenle bir grup uzman tarafından Parkinson hastalarında MOB’i ortaya koymak amacıyla NMSQuest adlı anket tasarlanmıştır. Anket uluslararası çalışmalarla geçerlilik ve güvenilirliğini kazanmıştır. Biz çalışmamızda Parkinson hastalarında MOB’i saptamak amacıyla NMSQuest’i kullanmaya karar verdik. Böylece Türkiye’de bu alanda kullanılabilecek ölçeklerin varlığına dikkat çekmeyi istedik. Ayrıca MOB’de erken teşhis ile tedavinin önemini vurgulamayı amaçladık. Çalışmamıza 29’u kadın, 46 ‘sı erkek olmak üzere toplam 75 İdiyopatik Parkinson hastası alındı. İdiyopatik Parkinson Hastalığı’nın hastalık şiddeti ve evresi, ‘Hoehn-Yahr’ skalası ile değerlendirildi. Sonuçlar güncel literatür eşliğinde tartışıldı. Motor olmayan belirtilerin olgulardaki oranı ve hastalığın evresiyle ilişkisi benzer çalışmalarla karşılaştırıldı. Sonuç olarak erken teşhis ve tedavinin önemi vurgulanmıştır.Öğe Subjective Cognitive Impairment in Major Depressive Disorder: Predictors and Clinical Outcomes(Alanya Alaaddin Keykubat Üniversitesi, 2025) Çankaya, Şeyda; Yuluğ, BurakAim: Individuals with subjective cognitive impairment (SCI) and major depressive disorder (MDD) are at high risk of developing neurodegenerative diseases. Studies suggest that SCI may be associated with concurrent cognitive performance and is also strongly associated with depressive symptoms. In this context, we aimed to evaluate the relationship between SCI and depression severity and to reveal predictive factors for SCI with current cognitive performance. Methods: Forty-two patients with MDD were divided into two groups: patients with and without SCI. All participants were administered the Montreal Cognitive Assessment (MoCA) and the Hamilton Depression Rating Scale (HAM-D). A logistic regression model was used to add demographic characteristics to the results obtained. Results: Individuals with SCI (n=21) were older (p=0.014) and less educated (p=0.006) than non-SCI patients (n=21) with MDD. Additionally, the mean of the MoCA total score was significantly higher in the non-SCI group (Student's t Test, p=0.011). Depression severity was the same throughout the groups (HAM-D, ??2: 2.10, p= 0.28). Language dysfunction is one of the MoCA subtests, language impairment emerged as a key predictor in the binary logistic regression model, identified through Backward Wald elimination, for detecting depressive patients with SCI (p=0.007; OR=0.366; 95% CI 0.177-0.756). Conclusion: Our findings suggest that SCI accurately reflects concurrent cognitive performance in a clinic-based sample of MDD. The results also suggest that the clinical interpretation of SCI should take into account the possible impact of depression on the language domain.Öğe The association of non-motor symptoms with motorsymptoms in parkinson’s disease(2021) Çankaya, ŞeydaAim: Idiopathic Parkinson’s disease (IPD) is the second most common progressive neurodegenerative disorder and well known with typical motor impairment. Besides motor symptoms, non-motor symptoms (NMS) occur very frequently among patients with IPD. This study aims to assess the presence of non-motor symptoms with the severity of motor symptoms.Materials and Methods: Alaaddin Keykubat University Training and Research Hospital’s database has been screened for identifying patients with IPD from 2015-2019. The patients’ motor symptom, NMS, and Hoehn & Yahr stage (H&Y stage) were assessed with the Movement Disorder Society - Unified Parkinson’s Disease Rating Scale (MDS-UPDRS).Results: A total of 50 IPD patients were analyzed. Analysis by NMS part of MDS-UPDRS (Part I) showed that NMS was present in 99.7% of patients. NMS part score was positively correlated with H&Y stages and total motor scores of MDS-UPDRS (part II-III). The most common symptoms were pain (84%), daytime sleepiness (78%), and urinary problems (76%). Significantly, there was an association between motor impairment, H&Y, and the following NMS items; hallucinations/psychosis, depressed mood, daytime sleepiness, urinary problems, constipation, light-headedness on standing, and fatigue (p<0.05, Spearman’s rho). Conclusions: Considering our data suggested that almost all patients with PD experience NMS. NMS are mostly worsened with exacerbation of MS (motor symptoms) and H&Y in cases. These findings will help understand the clinical aspect of PD and may improve personalized medicine and research in PD.Öğe The effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model(2022) Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakaris, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, BurakObjectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.Öğe The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy(Alanya Alaaddin Keykubat Üniversitesi, 2019) Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Hanoğlu, LütfüAim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported retrogradely towards the cell body and the deprivation of the trophic factors lead to the degeneration and death of the injured neuron. Rifampicin is an antibiotic exhibiting several neuroprotective functions in various neurodegenerative conditions. Here we aim to investigate the acute neuroprotective effect of rifampicin in primary cortical neuron culture in which neurons are axotomized by laser axotomy. Methods: Neonatal male mice were used in order to isolate cortical neurons. Isolated primary cortical neurons were cultured. After 24 hours three different rifampicin concentrations (1 µM, 10 µM and 100 µM) were applied to the neurons and after 15 minutes of rifampicin addition, neurons were laser axotomized. Viability of the cells was evaluated by propidium iodide staining after 24 hours of axotomy. Results: Laser axotomy decreases the cortical neuron viability significantly by 80.45%, while rifampicin pre-treatment increases their viability in all three dosages in a statistically significant manner. Conclusion: Rifampicin has an acute neuroprotective effect on the viability of the laser axotomized cortical neurons.Öğe The relationship between the changes in inflammatory parameters and response to treatment in major depression patients starting antidepressant treatment(2021) Uygur, Abdullah Burak; Çankaya, ŞeydaAim: Changes in inflammatory parameters such as cytokines, stress hormones and C reactive protein that occur in depression, are important in understanding the pathophysiology of depression and developing new treatment approaches. The main purpose of this study was to determine the changes in inflammatory markers in patients with major depression, before and after antidepressant treatment, as well as to determine the effect of antidepressant treatment types on these changes. Methods: This study was a single center, retrospective study. According to the retrospective records of the last five years in the psychiatry outpatient clinic of Alanya Alaaddin Keykubat University Training and Research Hospital, the patients diagnosed with Major Depressive Disorder (MDD), started on single antidepressant treatment for the first time and who used antidepressant treatment for at least 6-8 weeks, were included in the study. Patients whose Hamilton Depression Rating Scale (HDRS), complete blood count, C reactive protein and cortisol values were reached from the system during MDD treatment, constituted the sample of the study. Results: In the present study, after the antidepressant treatment, while HDRS scores decreased significantly in patients with Major Depression compared to before treatment (p<0,001), no significant correlation was found between the changes in inflammatory parameters and the response to treatment (p>0,05). This condition was independent of the type of antidepressant used in the treatment (p>0,05 in the SSRI treatment group, p>0,05 in the SNRI treatment group). In addition, it was observed that the decrease in depression scores was not associated with the type of antidepressant (p=0,001, in the SSRI treatment group, p=0,005, in the SNRI treatment group). Conclusion: Results to support the inflammatory hypothesis in Major Depressive Disorder were not conclusive in this study. Considering that the pathophysiology of depression is quite complex, it could be argued that a single group of blood tests may not be sufficient to explain the link between inflammation and depression. Considering all the limitations of the study, a future a prospective study to prove the inflammatory hypothesis in MDD, including the detailed blood, BOS tests, along with more comprehensive neuroimaging parameters on the brain pathways, might provide more effective resultsÖğe The therapeutic role of minocycline in Parkinson's disease(Bioexcel Publishing LTD, 2019) Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ülkan; Kılıç, Ertuğrul; Yuluğ, BurakMinocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson's disease (PD), Huntington's disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD. © 2019 Cankaya S, Cankaya B, Kilic U, Kilic E, Yulug B. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.Öğe Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder(Churchill Livingstone, 2021) Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Öktem, Ece Özdemir; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfi; Hanoğlu, Lütfi; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, BurakAim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on multiple levels that goes beyond their conventional effects on neurotransmitters. Method: The study was approved by the Local Ethics Committee of Istanbul Medipol University (10840098-604.01.01-E.65129) and followed the Helsinki Declaration principles. In our study, we have evaluated the effect of six weeks of treatment with antidepressants (escitalopram and duloxetine), and tested the underlying brain functional connectivity through a Graph analysis approach in a well-defined first-episode, drug-naive, and non-comorbid population with MDD. Results: Beyond indicating that there was a significant correlation between the antidepressant response and topological characteristics of the brain, our results suggested that global rather than regional network alterations may be implicated in the antidepressant effect. Conclusion: Despite the small-sample size and non-controlled study design, our study provides important and relevant clinical data regarding the underlying mechanisms of the antidepressants on topological dynamics in the human brain. © 2020 Elsevier LtdÖğe Translational perspective: is cinnamon a suitable agent for cognitive impairment and Alzheimer's disease associated with brain trauma(Wolters Kluwer Medknow Publications, 2019) Yuluğ, Burak; Çankaya, Şeyda[No abstract available]
