n vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract

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dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorDaylan, Benay
dc.contributor.authorGüzel, Elif
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorGünal, Mehmet Yalçın
dc.date.accessioned2026-01-24T11:57:10Z
dc.date.available2026-01-24T11:57:10Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractCarduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the genus Carduus is limited which remarks the significance of the current study. This study aims to investigate the antibacterial, antioxidant, and wound-healing properties of the methanolic extract of Carduus adpressus. Extract was obtained by maceration. The broth microdilution assay was performed on Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli. DPPH and ABTS radical scavenging assays were performed to detect the antioxidant capacity. Wound-healing activity was tested using alloxan-induced diabetic BALB-c mice. 4 groups, control, vehicle, CAE and Carduus adpressus groups were treated with the relative agent for 10 days. Extract demonstrated 62.5 ?g/mL MIC against S. aureus and E. faecalis, and 125 ?g/mL MIC against P. aeruginosa and E. coli. ABTS assay showed higher antioxidant activity compared to the DPPH assay. Carduus adpressus group demonstrated strong regeneration, epithelisation, and angiogenesis compared to the control group on day 10. Additionally, expression of PDGF, VEGF, and collagen formation was increased in the Carduus adpressus group compared to the control group on day 10. Extract demonstrated strong antibacterial, antioxidant, and wound-healing activities which indicate that it could be a source in developing wound-healing agents.
dc.identifier.endpage676
dc.identifier.issn2630-6344
dc.identifier.issue2
dc.identifier.startpage665
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3668
dc.identifier.volume27
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260121
dc.subjectMedical Pharmacology
dc.subjectTıbbi Farmakoloji
dc.titlen vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
dc.typeArticle

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