TÜRK POPÜLASYONUNDA ACE I/D VARYANTI OSCC İÇİN BİR RİSK FAKTÖRÜ OLABİLİR FAKAT PON1 L55M RİSK FAKTÖRÜ DEĞİLDİR
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İstanbul Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Oral skuamöz hücreli karsinom (OSCC), ağızdaki malign neoplazm ların %90’ından fazlasını kapsar. Anjiyotensin dönüştürücü enzim (ACE) ve paraoksonaz (PON1) gen varyantlarının birçok kanserle ilişkili olduğu gös terilmiştir. Bu nedenle, Türk popülasyonunda ACE I/D-PON1 L55M var yantları ile OSCC gelişim riski arasındaki olası ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Çalışma popülasyonu toplam 155 bireyden oluşmak taydı (51 OSCC hastası ve 104 sağlıklı kontrol). ACE I/D - PON1 L55M var yantları, PCR ve RFLP analizleri kullanılarak genotiplendi. Bulgular: ACE I/D alel frekansları hastalar ve kontroller arasında anlamlı şekilde farklılık göstermiştir. ACE D aleli, hasta grubunda kontrol grubuna kıyasla daha yüksek iken, I aleli kontrollerde hastalara kıyasla daha fazlaydı (p?0,0000001). Hastalar ile kontroller, II+ID vs. DD genotipine (p=0,0000001) ve II: ID vs. DD’ye (p=0,008691) göre karşılaştırıldığında istatistiksel olarak anlamlı bir ilişki gözlendi. PON1 L55M genotipi veya alel dağılımı açısından hastalar ve kontroller arasında anlamlı bir fark buluna madı (p>0,05). Sonuç: Sonuç olarak çalışmamız ACE I/D varyant D alelinin Türkiye’de OSCC gelişimi için risk faktörü olduğunu gösterdi. Bu çalışma, ACE I/D’nin OSCC için genetik bir risk faktörü olarak rol oynadığını doğrulamak amacıyla yapılacak daha fazla araştırmaya katkı sağlamaktadır.
Objective: Oral squamous cell carcinoma (OSCC) covers more than 90% of the malignant neoplasms in the mouth. It has been shown that angiotensin-converting enzyme (ACE) and paraoxonase (PON1) gene variants were associated with several cancers. Therefore, we investigated the possible association between ACE insertion/deletion (I/D)-PON1 L55M variants and OSCC development risk in a Turkish population. Material and Methods: A total of 155 people (104 healthy controls and 51 OSCC patients) made up the study population. These variants were genotyped using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) assays. Results: ACE I/D allele frequencies were significantly different between patients and controls. The ACE D allele was higher in the patient group compared to the control group, while the I allele was more prevalent in controls than patients (p?0.0000001). When the patients and controls were examined based on the II+ID vs. DD genotype and II: ID vs. DD, a statistically significant correlation was found (p = 0.0000001 and p = 0.008691, respectively). The genotype and allele distribution of PON1 L55M did not significantly differ between the groups. Conclusion: In conclusion, our study showed that the ACE I/D variant D allele is a risk factor for the development of OSCC in Turkey. This study contributes to more studies to confirm that ACE I/D plays a role as a genetic risk factor for OSCC.
Objective: Oral squamous cell carcinoma (OSCC) covers more than 90% of the malignant neoplasms in the mouth. It has been shown that angiotensin-converting enzyme (ACE) and paraoxonase (PON1) gene variants were associated with several cancers. Therefore, we investigated the possible association between ACE insertion/deletion (I/D)-PON1 L55M variants and OSCC development risk in a Turkish population. Material and Methods: A total of 155 people (104 healthy controls and 51 OSCC patients) made up the study population. These variants were genotyped using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) assays. Results: ACE I/D allele frequencies were significantly different between patients and controls. The ACE D allele was higher in the patient group compared to the control group, while the I allele was more prevalent in controls than patients (p?0.0000001). When the patients and controls were examined based on the II+ID vs. DD genotype and II: ID vs. DD, a statistically significant correlation was found (p = 0.0000001 and p = 0.008691, respectively). The genotype and allele distribution of PON1 L55M did not significantly differ between the groups. Conclusion: In conclusion, our study showed that the ACE I/D variant D allele is a risk factor for the development of OSCC in Turkey. This study contributes to more studies to confirm that ACE I/D plays a role as a genetic risk factor for OSCC.
Açıklama
Anahtar Kelimeler
Oral Medicine and Pathology, Oral Tıp ve Patoloji, Medical Genetics (Excl. Cancer Genetics), Tıbbi Genetik (Kanser Genetiği hariç)
Kaynak
Sağlık Bilimlerinde İleri Araştırmalar Dergisi
Journal of Advanced Research in Health Sciences
Journal of Advanced Research in Health Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
1
