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    Investigation of the ACTN3 Gene Polymorphism (rs1815739) and FMS Values in Young Runners: Cross-Sectional Research
    (2023) Bulğay, Celal; Bayraktar, Işık; Odemıs, Merıc; Yildirim, Damla Selin; Ergun, Mehmet Ali; Cerıt, Mesut; Ulucan, Korkut
    Objective: The present study aims to examine investigation the ?-actinin-3 (ACTN3) gene polymorphism (rs1815739) and functional movement screen (FMS) values in young runners competing at the national level. Material and Methods: Forty-five young runners (29 male 64.4%, 16 female 35.6%) competing at the national level in different clubs affiliated to the Turkish Athletic Federation and training regularly at least 5 days a week voluntarily participated in the study. The DNA isolation of oral swab samples was carried out using the spin column (MN Macherey-Nagel, Germany) method. The genotyping pro- cess was performed using the real-time polymerase chain reaction method. Results: The FMS test battery was used to determine the functional capacity. According to the findings obtained, it was determined that in the FMS evaluation of the female runners, the runners with the CC genotype had a significantly higher mean score compared to the runners with the CT genotype (p<0.033) while in the male runners, the runners with the CT genotype had a significantly higher mean score compared to the runners with the TT genotype (p<0.031). However, in the FMS evaluation of the overall runners, no significant difference was found (p>0.205). Conclusion: It is thought that the FMS test battery and the ACTN3 gene polymorphism, which is among the important variables responsible for non-impact injuries, can be effective in the level of muscle damage, the type of muscle injury, the prediction of injuries and reducing the risk factors that may cause injuries.