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    Dental Pulp-Derived Mesenchymal Stem Cells Increase Axon Numbers in Mental Nerve Repair
    (Springer India, 2024) Gonen, Zeynep Burcin; Colpak, Halis Ali; Yay, Arzu; Gokdemir, Nur Seda; Bahar, Dilek; Canpolat, Dilek Gunay; Yalcin, Betul
    AimThe mental nerve, the extended part of the inferior alveolar nerve, is often injured during dentoalveolar, orthognathic, or tumor surgery. Numerous therapeutic interventions, including surgery and pharmacotherapy, have been used to enhance the recovery of nerve injuries. Dental pulp stem cells (DPSCs) represent an easily accessible source of adult stem cells that can be isolated from the pulp of extracted teeth. This study evaluated the effect of DPSCs on the regeneration of the mental nerve injury model of rabbits.MethodsIn this presented study, DPSCs were cultured and cell characterizations were performed by using flow cytometry and immunostainings. Bilateral mental nerve injury models of rabbits were created. In the control group (n = 10), saline was applied, and in the study group (n = 10), 2 x 106 DPSCs were applied to the repaired nerve areas. After 3 weeks, animals were killed and histological examination was obtained by using Masson's trichrome staining. An unpaired Student's t test was used when comparing the groups. Differences were considered to be statistically significant at P values of less than 0.05.ResultsThe DPSCs demonstrated a homogeneous population of mesenchymal stromal cells which expressed cluster of differentiation CD44, CD73, CD90, and CD105 and lack of CD34, CD45, and HLA-DR. Our finding clearly demonstrated that a lower number of cross-sectioned axons were founded in the control group (60.18 & PLUSMN; 2.52) compared to the study group (72.96 & PLUSMN; 2.43) (p = 0.00).ConclusionsDPSCs promote mental nerve axonal regeneration. These results suggest that DPSCs provide an important accessible source of adult stem cells for mental nerve regeneration.
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    Öğe
    Determination of effects of chemical agencies on liver fibrosis models frequently used in different dose and time periots
    (2021) Kaan, Dilek; Toprak, Güler; Yay, Arzu; Başkol, Gülden; Ertekin, Tolga; Ülger, Harun
    Aim: In this study, it was aimed to reveal a more effective model depending on the dose and time by evaluating histopathological properties and biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, triglyceride, cholesterol in carbon tetrachloride and thioacetamide (CCl4 and TAA) models. Method: Rats were divided into three groups for each model and intraperitoneally (i.p.) injected with CCl4 (0.5 ml/kg, 1.0 ml/kg, 2.0 ml/kg) and TAA (100 mg/kg, 200 mg/ kg, 300 mg/kg) for 4, 6 and 8 weeks, three times weekly, respectively. Results: In the biochemical investigation, ALT and AST values in the only 0,5 ml CCL4 of groups for 6 and 8 weeks and were found to have significant differences compared to the control groups (p <0.05), while the other biochemicals parameters values did not reveal significant difference in the groups (p >0.05). According to the results of the histopathology in the liver tissues, both the control groups showed a normal histological feature. The hepatofibrotic alterations were remarkable in the CCl4 and TAA models fibrosis depending on the increasing dose and time in all of the groups. Conclusion: Our results showed that the dose and time were reached up to until the cirrhosis for eighth week. These results would be a helpful reference for hepatofibrotic studies.