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    Does previous tuberculosis increase the risk of functional gastrointestinal disorders in children?
    (2024) Uygun, Hatice; Yavuz, Sibel; Erdem, Nurettin; Oktay, Saniye Başak; Ozen, Seval; Turgut, Mehmet
    Objective: Functional gastrointestinal disorders (FGIDs) encompass a range of chronic conditions of unknown etiology, including functional dyspepsia, irritable bowel syndrome, functional abdominal pain, and functional constipation. The exact pathogenic mechanisms behind tuberculosis (TB) are unclear. This study aimed to investigate whether children with previous TB are at an increased risk of developing FGIDs after completion of TB treatment. Materials and Methods: A total of 35 patients diagnosed with TB (age range, 24 to 216 months) and 49 age- and sex-matched healthy controls were included in this retrospective study. Patients were evaluated for the presence of FGID symptoms after at least 6 months had passed after cessation of TB treatment, while the control group was assessed at the time of their first examination according to the Rome IV criteria. Results: The overall prevalence of FGIDs was 42.9% (n=15) in the patient group versus 12.2% (n=6) in the control group. A significant difference was found between the groups in terms of the frequency of FGIDs and the diagnosis of functional abdominal pain (p = 0.001 and p < 0.001, respectively). Conclusions: This study demonstrated a higher prevalence of FGIDs in children with a history of TB compared to healthy controls, supporting the hypothesis that FGIDs are more common in children with previous TB. Children with previous TB may be at an increased risk for FGIDs, possibly due to chronic inflammation and immune system alterations associated with TB, highlighting the need for ongoing assessment of GI health in this population.
  • [ X ]
    Öğe
    Does previous tuberculosis increase the risk of functional gastrointestinal disorders in children?
    (Galenos Publ House, 2024) Uygun, Hatice; Yavuz, Sibel; Erdem, Nurettin; Oktay, Saniye Basak; Ozen, Seval; Turgut, Mehmet
    Objective: Functional gastrointestinal disorders (FGIDs) encompass a range of chronic conditions of unknown etiology, including functional dyspepsia, irritable bowel syndrome, functional abdominal pain, and functional constipation. The exact pathogenic mechanisms behind tuberculosis (TB) are unclear. This study aimed to investigate whether children with previous TB are at an increased risk of developing FGIDs after completion of TB treatment. Materials and Methods: A total of 35 patients diagnosed with TB (age range, 24 to 216 months) and 49 age- and sex-matched healthy controls were included in this retrospective study. Patients were evaluated for the presence of FGID symptoms after at least 6 months had passed after cessation of TB treatment, while the control group was assessed at the time of their first examination according to the Rome IV criteria. Results: The overall prevalence of FGIDs was 42.9% (n=15) in the patient group versus 12.2% (n=6) in the control group. A significant difference was found between the groups in terms of the frequency of FGIDs and the diagnosis of functional abdominal pain (p = 0.001 and p < 0.001, respectively). Conclusions: This study demonstrated a higher prevalence of FGIDs in children with a history of TB compared to healthy controls, supporting the hypothesis that FGIDs are more common in children with previous TB. Children with previous TB may be at an increased risk for FGIDs, possibly due to chronic inflammation and immune system alterations associated with TB, highlighting the need for ongoing assessment of GI health in this population.
  • [ X ]
    Öğe
    Is Rectal Diameter a Predictor of Daytime Urinary Incontinence in Pediatric Patients?
    (2024) Işık, Güneş; Oktay, Cemil; Yavuz, Sibel
    Aim: With this study, we aimed to evaulate the relationship between daytime urinary incontinence and transverse rectal diameter by using transabdominal ultrasound. Methods: In this study, pediatric patients were evaluated with symptoms of daytime urinary incontinence referred to the pediatric nephrology clinics of Adıyaman University Faculty of Medicine between November 1, 2022 and January 1, 2023. This observational, cross-sectional study was carried out after obtaining ethics approval. The Dysfunctional Voiding Symptom Score developed by the International Children’s Continence Society was used for the diagnosis of lower urinary tract symptoms. Patients with a The Dysfunctional Voiding Symptom Score of ?9 points were considered as having lower urinary tract symptoms. Transvers rectal diameter measurement was obtained behind the bladder in the axial plane from the outer wall to the outer wall of the rectum. The patients were assessed by the same radiologist. Control group consisted of healthy patients without lower urinary tract symptoms. Results: A total of 77 children were included in the study. The daytime urinary incontinence group included 39 children (19 boys, 20 girls), while the control group included 38 (16 boys, 22 girls) healthy children. There was no statistically significant difference between the patient group with daytime urinary incontinence and healthy control group when compared in terms of transverse rectal diameter measurements (p=0.387, t=0.870). There was no association between transverse rectal diameter and daytime urinary incontinence (p>0.05). Conclusion: Our data suggest that increased rectal diameter is not the only predisposing factor for daytime urinary incontinence and neural mechanisms such as cross-organ sensitization are also may be effective in daytime urinary incontinence.