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    Comparison of retinal vascular structure in eyes with and without amblyopia by optical coherence tomography angiography
    (Slack Incorporated, 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan
    Purpose: To evaluate the retinal vascular structure in amblyopic eyes by optical coherence tomography angiography (OCTA). Methods: Thirty-seven eyes of 37 patients with anisometric amblyopia were compared with 37 eyes of 37 age- and gender-matched control subjects by OCTA in terms of superficial capillary plexus vessel density, deep capillary plexus vessel density, and foveal avascular zone. Results: The mean age was 12 ± 4.2 years in patients with amblyopia and 13 ± 6.1 years in individuals without amblyopia. Foveal superficial capillary plexus vessel densities were 20.49% ± 3.27%, 19.70% ± 3.82%, and 19.96% ± 3.84%, and parafoveal superficial capillary plexus vessel densities were 48.50% ± 3.64%, 49.01% ± 3.33%, and 48.9% ± 2.98% in amblyopic, fellow, and control eyes, respectively. The foveal deep capillary plexus vessel densities were 18.95% ± 3.76%, 18.6% ± 4.50%, and 19.29% ± 4.01%, and parafoveal deep capillary plexus vessel densities were 51.0% ± 4.21%, 51.85% ± 4.12%, and 52.03% ± 3.57% in amblyopic, fellow, and control eyes, respectively. Superficial and deep capillary plexus vessel densities in the foveal and parafoveal areas were not significantly different between the groups (P > .05). The parafoveal area was evaluated in quadrants. In the superior quadrant, superficial and deep capillary plexus parafoveal densities were significantly lower in amblyopic eyes (P < .05). No significant difference was observed in the foveal avascular zone between the groups (P > .05). Conclusions: Although no significant vascular damage was demonstrated by OCTA in amblyopic eyes, localized defects may be specific for it. Additional studies are needed to evaluate any specific localization of vascular damage related to amblyopia. Copyright © SLACK Incorporated
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    Comparison of wavefront aberrations in eyes with multifocal and monofocal iols before and after Nd:YAG laser capsulotomy for posterior capsule opacification
    (Springer Science+Business Media B.V., 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan
    Purpose: The aim of this study was to compare wavefront aberrations before and after Nd:YAG capsulotomy in multifocal intraocular lens (MfIOL) and monofocal (MoIOL) pseudophakic eyes with posterior capsule opacification (PCO). Materials and methods: Wavefront aberrations were measured using a ARK-10000 topographer before and after Nd:YAG capsulotomy in eyes that underwent MfIOL or MoIOL implantation and developed PCO. Total and higher-order aberrations (HOAs) values were evaluated as root mean square (RMS). Results: The study included 64 eyes with MfIOLs (64 patients) and 72 with MoIOLs (72 patients) that developed PCO. Total RMS values before and 1 month after Nd:YAG capsulotomy were 0.863 ± 0.27 and 0.504 ± 0.24 in the MFIOL group and 0.862 ± 0.31 and 0.466 ± 0.26 in the MoIOL group, respectively. Total RMS values did not differ significantly between the groups before (p = 0.914) or 1 month after Nd:YAG laser capsulotomy (p = 0.357), but decreased significantly after Nd:YAG capsulotomy compared to baseline in both the MfIOL (p = 0.027) and MoIOL (p = 0.012) groups. HOA values before and 1 month after Nd:YAG capsulotomy were 0.546 ± 0.23 and 0.364 ± 0.19 in the MfIOL group and 0.500 ± 0.21 and 0.346 ± 0.18 in the MoIOL group, respectively. HOA values did not differ significantly before (p = 0.828) or after Nd:YAG capsulotomy (p = 0.111), while both groups showed significant reduction in HOAs after Nd:YAG capsulotomy (MfIOL: p = 0.021, MoIOL: p = 0.027). Conclusions: Nd:YAG capsulotomy reduces total and HOAs to the same extent in eyes with both MfIOLs and MoIOLs, with no significant impact of the IOL design. © 2020, Springer Nature B.V.
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    Corneal sensitivity and ocular surface health in patients undergoing femtosecond LASIK retreatment for residual refraction
    (Lippincott Williams and Wilkins, 2024) Çinar, Esat; Yüce, Berna; Aslan, Fatih
    Purpose:To assess corneal sensitivity and the ocular surface in patients undergoing primary femtosecond laser in situ keratomileusis (FS-LASIK) and those undergoing FS-LASIK retreatment under the same flap due to residual refractive error.Setting:Ekol Eye Hospital, Izmir, Turkey.Design:Prospective case series.Methods:19 patients with previous FS-LASIK who had myopic and astigmatic refractive error were included in the study group, and 19 age-matched and sex-matched patients undergoing FS-LASIK for the first time as the control group. Corneal sensitivity, Schirmer test, tear film break-up time (TBUT), Oxford grading scheme for ocular surface staining, and Ocular Surface Disease Index (OSDI) were measured preoperatively and at postoperative 1 week and 1, 3, and 6 months.Results:The mean refractive correction in the study and control groups, respectively, was 2.18 ± 0.78 diopters (D) (range: 1.00 to 3.50) and 2.76 ± 1.20 D (range: 1.00 to 4.50; P =.07). Corneal esthesiometry results in the study and control groups, respectively, were 6.10 ± 12.55 vs 9.90 ± 11.50 mm at 1 week (P =.001), 41.95 ± 6.98 vs 45.09 ± 5.88 mm at 1 month (P =.004), 56.09 ± 3.37 vs 56.19 ± 2.52 mm at 3 months (P =.8), and 58.60 ± 2.01 vs 58.80 ± 1.39 mm at 6 months (P =.5). Significant difference between the 2 groups in Schirmer test score that disappeared at postoperative 3 months and in TBUT and ocular surface staining that disappeared at 6 months, whereas the statistically significant difference in OSDI score persisted at 6 months (P =.03) was detected.Conclusions:Corneal surface sensitivity and ocular surface health are more impaired in patients undergoing FS-LASIK retreatment due to residual refractive error. ©2024 Published by Wolters Kluwer on behalf of ASCRS and ESCRS. Unauthorized reproduction of this article is prohibited.
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    Effect of neuroprotective citicoline eye drops on macular microcirculation
    (NLM (Medline), 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan
    BACKGROUND AND OBJECTIVE: To use optical coherence tomography (OCTA) examination of the retinal microvascular structures to evaluate the effect of neuroprotective eye drops (citicoline, OMK1®) administered for laser in situ keratomileusis (LASIK) surgery. PATIENTS AND METHODS: This prospective study included 45 patients treated with citicoline after LASIK and 48 patients not treated with citicoline after LASIK as a control group. In both groups, the foveal avascular zone (FAZ), retinal superficial vascular density (SVD), and deep vascular density (DVD) in the foveal and parafoveal areas were measured preoperatively and at 1 and 3 months postoperatively using OCTA. RESULTS: No significant difference was detected between the groups in terms of preoperative SVD or DVD in the foveal and parafoveal zones and all quadrants (superior, inferior, temporal, and nasal) (P?>?0.05). Similarly, no significant difference was detected between the citicoline group and control group in terms of SVD or DVD in the foveal and parafoveal zones at 1 and 3 months after LASIK (P?>?0.05). CONCLUSIONS: Despite their neuroprotective effect, topical citicoline drops had no significant effect on the superficial and deep microvascular structures of the retina or choriocapillaris.
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    Evaluation of early retinal and choroidal microvascular changes in type 2 diabetes patient without retinopathy
    (Gazi Eye Foundation, 2020) Çınar, Esat; Yüce, Berna; Aslan, Fatih
    Purpose: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM) without diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: A total of 48 DM and 48 healthy control subjects were included. Mean superficial and deep vessel density (SVD, DVD) and flow in superficial and deep layers, choriocapillaris (CC) and FAZ area were measured by OCTA for analysis. Also, patients were categorized into two groups as high-risk (? 5 years) and low-risk (< 5 years) according to the duration of DM. Results: SVD did not change in eyes without DR, but DVD significantly decreased when compared to healthy controls (p< 0.05). Both superficial and deep layer's flow did not change in diabetic patients who had a significant enlargement in FAZ area. CC flow area and CC thickness did not change in DM patients (p> 0.05). The mean DVD and FAZ area were correlated with HbA1c levels and the duration of DM. Comparison between the high-risk (20 patients) and low-risk groups (28 patients) revealed significant difference in superficial and deep layer's flow, CC and FAZ area (p<0.05). Also, SVD and DVD measurements of the DM patients were significantly different between high-risk and low-risk groups for all macular regions (p<0.05 for all). Conclusions: OCTA can show the damage in patients without any clinically significant DR before the clinical manifestation in diabetic patients. Our results suggested that OCTA might be a promising tool for periodic screening of diabetic patients without DR. © 2020 Gazi Eye Foundation. All rights reserved.
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    Evaluation of retinal and choroidal microvascular changes in patients who received hydroxychloroquine by optical coherence tomography angiography
    (NLM (Medline), 2021) Çınar, Esat; Yüce, Berna; Aslan, Fatih
    PURPOSE: The aim of the study is to evaluate the retinal and choroidal microvascular changes via optical coherence tomography angiography in patients who received hydroxy-chloroquine. METHODS: In total, 28 eyes of 28 patients (24 females, and 4 males) receiving treatment with hydroxy-chloroquine were assessed in this cross-sectional cohort study (hydroxychloroquine group). The high-and low-risk groups consisted of patients receiving hydroxychloroquine for ?5 years (14 eyes of 28 patients) and <5 years (14 eyes of 28 patients), respectively. A total of 28 age- and gender-matched volunteers were enrolled as the control group. The macular flow area (superficial, deep, and choriocapillaris), superficial and deep vessel density, foveal avascular zone area, central foveal thickness, and subfoveal choroidal thickness parameters were measured by optical coherence tomography angiography. RESULTS: The mean age of the 28 patients who received hydroxychloroquine and the 28 age-matched controls was 45.5 ± 11.1 years (range: 29-70 years) and 44.5 ± 13.9 years (range: 28-70 years), respectively. In patients who received hydroxychloroquine, the values for the superficial, deep, and choriocapillaris macular flow areas were 13.578 ± 0.30, 13.196 ± 0.31, and 17.617 ± 0.42, respectively. In controls, these values were 16.407 ± 0.95, 13.857 ± 0.31, and 18.975 ± 0.76, respectively (p<0.05 for all). The superficial, deep, and cho-riocapillaris flow areas were significantly smaller in patients who received hydroxychloroquine than those in controls (p<0.05 for all). Superficial and deep vessel densities were significantly reduced in patients who received hydroxychlo-roquine in all regions (i.e., foveal, parafoveal, temporal, superior, nasal, and inferior) (p<0.05 for all). Moreover, significant difference was observed between the groups in the foveal avascular zone area (superficial and deep), central foveal thickness, and subfoveal choroidal thickness (p<0.05 for all). CONCLUSIONS: Retinochoroidal microvascular flow and vessel density of the macular area were significantly decreased in patients who received hydroxychloroquine. Hy-droxychloroquine may damage the retinochoroidal mi-cro-vascular architecture. Optical coherence tomography angiography may contribute to the early detection of hy-dro-xychloroquine-induced retinal toxicity.
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    Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography
    (Springer, 2020) Yüce, Berna; Çınar, Esat; Aslan, Fatih; Küçükerdönmez, Cem
    Purpose To evaluate the retinal vascular structure before and after the epiretinal membrane (ERM) surgery by optical coherence tomography angiography (OCTA). Methods Twenty-two eyes with ERM (study eyes) had been evaluated by OCTA for superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density (VD) at foveal and parafoveal regions and foveal avascular zone (FAZ) before and after ERM removal surgery. Twenty-two fellow eyes were selected as control group. Results Preoperative VD of SCP and DCP were significantly lower in ERM eyes than in controls in both foveal and parafoveal areas (p < 0.05, for all). The difference regressed in SCP (fovea: 18.04 +/- 3.1 vs 19.98 +/- 18p = 0.002 and parafovea: 47.33 +/- 3.54 vs 49.71 +/- 28p = 0.001), but persisted in DCP (fovea: 17.25 +/- 3.52 vs 17.57 +/- 4.01p = 0.856 and parafovea: 50.12 +/- 4.35 vs 50.93 +/- 3.24p = 0.791) in study eyes, postoperatively. Superficial and deep FAZ areas were significantly smaller in study eyes than controls. Postoperatively, superficial FAZ area enlarged (0.288 +/- 0.10 vs 0.307 +/- 0.08p = 0.012), whereas deep FAZ area did not (0.324 +/- 0.09 vs 0.338 +/- 0.07p = 0.435). FAZ area was correlated with the best-corrected visual acuity in ERM eyes. Conclusion Vascular damage in SCP and DCP was demonstrated by OCTA in eyes with ERM. ERM removal surgery mainly improves superficial changes caused by ERM. Changes in deep retinal flow may be associated with visual outcomes after ERM removal surgery.
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    Influence of Nd:YAG laser capsulotomy on toric intraocular lens rotation and change in cylinder power
    (Lippincott Williams and Wilkins, 2024) Çinar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan
    Purpose:To investigate toric monofocal intraocular lens (TIOL) rotation and associated changes in cylinder power caused by Nd:YAG laser capsulotomy performed due to posterior capsule opacification (PCO).Setting:Ekol Eye Hospital, Izmir, Turkey.Design:Prospective case series.Methods:41 eyes of 20 women and 21 men were included in the study. Before and 1 month after Nd:YAG laser capsulotomy, TIOL tilt and decentration were determined with Scheimpflug camera, and TIOL axial rotation and the change in cylinder power induced by this rotation were measured by ray tracing aberrometry. The time interval between cataract surgery and Nd:YAG laser capsulotomy was noted.Results:Rotational misalignment of the TIOL was measured as 4.65 ± 2.75 degrees (range 0 to 11 degrees) before vs 6.97 ± 2.92 degrees (range 0 to 13 degrees) after capsulotomy, and absolute rotation was 2.75 ± 1.94 degrees (range 0 to 7 degrees, P =.028). Before and after Nd:YAG laser capsulotomy, cylinder power was 0.24 ± 0.70 diopter (D) (range 0.00 to 0.63 D) vs 0.56 ± 0.77 D (range 0.02 to 0.91 D), respectively, with an absolute change in cylinder power of 0.34 ± 0.22 D (range 0.01 to 0.90 D, P =.001). After capsulotomy, there was a significant decrease in IOL tilt in the horizontal and vertical planes and an increase in decentration (P <.05). Time interval (33.02 ± 12.9 months) and IOL horizontal decentration were independent factors affecting IOL rotation after capsulotomy (P <.05).Conclusions:Nd:YAG laser capsulotomy may cause TIOL rotation as well as tilt and decentration, resulting in a change in the TIOL's corrective effect on corneal astigmatism. Although this change was clinically insignificant, it may be beneficial to consider that TIOL rotational misalignment may occur in patients undergoing early capsulotomy. © 2024 Elsevier Inc.. All rights reserved.
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    Intraocular lens tilt and decentration after Nd:YAG laser posterior capsulotomy: Femtosecond laser capsulorhexis versus manual capsulorhexis
    (Elsevier Inc., 2019) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan; Küçükerdönmez, Cem
    Purpose: To compare intraocular lens (IOL) tilt and decentration after Nd:YAG laser posterior capsulotomy in eyes that had femtosecond laser–assisted capsulotomy versus manual capsulorhexis. Setting: Ekol Eye Hospital, Izmir, Turkey. Design: Retrospective case series. Methods: Intraocular lens decentration and angle of tilt were measured using a Scheimpflug camera before and 1 month after Nd:YAG capsulotomy. Results: Eighteen eyes had a femtosecond laser–assisted capsulotomy and 25 eyes a manual capsulorhexis. The mean age was 58.2 years ± 10.2 (SD) (range 44 to 69 years) and 60.6 ± 8.3 years (range 45 to 70 years), respectively. Before capsulotomy, the angle of tilt and decentration at both meridians did not differ significantly between the 2 groups (P > .05). After capsulotomy, the angle of tilt was significantly decreased in both groups (femtosecond: vertical 1.5 degrees and horizontal 1.2 degrees; manual: vertical 1.1 degrees and horizontal) and decentration was significantly increased (femtosecond: vertical 0.085 mm and horizontal 0.096 mm; manual: vertical 0.2 mm and horizontal 0.2 mm) at both meridians (P < .05). After capsulotomy, all tilt and decentration parameters were significantly different between the 2 groups (P < .05) except decentration on the horizontal meridian (P = .669). Conclusions: Nd:YAG posterior capsulotomy performed after femtosecond laser–assisted capsulotomy resulted in better mechanical stability of the IOL. This suggests that a femtosecond laser–created capsulotomy better maintains a proper IOL position. Although the differences were statistically significant, the tilt and decentration values were small and might not be clinically significant. © 2019 ASCRS and ESCRS
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    Kapama tedavisi alan ve almayan ambliyop çocuklarda retina vasküler yapısının optik koherans tomografi anjiyografi ile karşılaştırılması
    (2019) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan; Küçükerdönmez, Fehmi Cem
    Amaç: Kapama tedavisi alan ambliyop çocuklar ile kapama tedavisi almayan ambliyop çocuklarda retina yüzeyel kapiller pleksus ve derin kapiller pleksus yapısını optik koherans tomografi anjiyografi ile değerlendirmek. Gereç ve Yöntem: Kesitsel vaka kontrollü yapılan bu çalışmada kapama tedavisi alan 20 anizometropik ambliyop hastanın 20 ambliyop gözü (Grup 1) ve anizometropik ambliyopisi bulunan ancak hiç kapama tedavisi yapılmamış 25 hastanın 25 ambliyop gözü (Grup 2) ve sağlıklı 45 hastanın 45 gözü (kontrol grubu; Grup 3) çalışmaya dahil edildi. Tüm gözlerde 3x3 mm alan haritasında optik koherans tomografi anjiyografi ile ölçülen retinanın yüzeyel ve derin vasküler yapı dansitesi ve foveal avasküler alan karşılaştırıldı. Bulgular: Grup 1, 2 ve 3’teki hastaların yaşları sıra ile 6,1 ± 1,02, 5,9 ± 0,92 ve 6,0 ± 0,93 idi (p >0,05). Foveal alanda yüzeyel kapiller pleksus vasküler dansitesi Grup 1, 2 ve 3’te sırası ile 20,45 ± 3,73, 21,39 ± 3,91, 20,24 ± 3,61 olarak ölçülürken, derin kapiller pleksus vasküler dansitesi 18,39 ± 3,05, 19,85± 4,38, 19,62 ± 5,53 olarak ölçüldü. Parafoveal alanda yüzeyel kapiller pleksus vasküler dansitesi Grup 1, 2 ve 3’te sırası ile 49,01 ± 4,84, 48,45 ± 3,01, 48,88 ± 3,76 olarak ölçülürken, derin kapiller pleksus vasküler dansitesi 52,54 ± 4,27, 49,45 ± 3,59, 52,01 ± 3,37 olarak ölçüldü. Foveal ve parafoveal alanda ne yüzeyel kapiller pleksus ne de derin kapiller pleksus tabakasında vasküler dansite açısından anlamlı fark görülmedi. Foveal ve parafoveal alanda yapılan foveal avasküler alan ölçümlerinde gruplar arasında anlamlı fark görülmedi. Sonuç: Retina vasküler yapısı, kapama tedavisi alan ambliyop gözler ile kapama tedavisi almayan ambliyop gözler arasında belirgin bir farklılık göstermemektedir
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    LASIK cerrahisinde menteşe pozisyonunun Kornea duyarlılığına ve kuru göze etkisi
    (2019) Çınar, Esat; Küçükerdönmez, Fehmi Cem; Erbakan, Gökhan; Yüce, Berna; Aslan, Fatih
    Amaç: Bu çalışmanın amacı farklı menteşe pozisyonları ile yapılan LASIK cerrahisinin kornea duyarlılığına ve kuru göze etkisini incelemektir. Gereç ve Yöntem: Çalışmamız prospektif, randomize vaka kontrollü bir çalışmadır. 104 hastanın randomize seçilen bir gözüne IntraLase femto saniye lazer kullanılarak nazal menteşeli flep açılırken (104 göz) diğer gözüne (104 göz) superior menteşeli flep ile miyopik LASIK cerrahisi yapıldı. Cochet-Bonnet esteziometresi ile kornea duyusu, Schirmer testi, gözyaşı kırılma zamanı tüm hastalarda ameliyat öncesi, ameliyat sonrası 1. hafta, 1, 3 ve 6. ay ölçümleri yapıldı. Bulgular: Kornea duyarlılığı ameliyat öncesi değerlere göre hem nazal hem de superior flep açılan hastalarda 3 ay boyunca azalmış olarak ölçülürken (p<.0001), 6. ay değerlerinde her iki menteşe pozisyonunda ameliyat öncesi değerler ile anlamlı fark görülmedi. Nazal menteşeli flep yapılan hastalar ile superior menteşeli hastalar karşılaştırıldığında ameliyat sonrası 1 ay boyunca korneal duyarlılık değerleri arasında anlamlı fark görülürken, 3. ve 6. ay değerleri arasında anlamlı fark görülmedi. Schirmer testi ve gözyaşı kırılma zamanı testleri ameliyat öncesindeki değerler ile karşılaştırıldığında her iki menteşe pozisyonunda 3 ay boyunca fark anlamlı iken, 6. ay değerleri arasında fark anlamlı değildi. Her iki menteşe pozisyonları Schirmer testi ve gözyaşı kırılma zamanı testleri açısından karşılaştırıldığında tüm takip süresince aradaki fark anlamlı değildi. Sonuç: Nazal menteşeli flep ile yapılan LASIK cerrahileri kornea duyarlılığı bakımından superior menteşeli fleplere göre daha üstündür ancak gözyaşı testleri açısından her iki menteşe pozisyonu arasında fark yoktur.
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    Neuroprotective effect of citicoline eye drops on corneal sensitivity after LASIK
    (Slack Incorporated, 2019) Çınar, Esat; Yüce, Berna; Aslan, Fatih; Erbakan, Gökhan
    Purpose: To evaluate the accelerator role of a topically administered neuroprotective eye drop (citicoline) on the recovery of corneal sensitivity after laser in situ keratomileusis (LASIK). Methods: In this prospective, controlled study, 78 eyes of 78 patients (mean age: 26.8 ± 7.6 years) were enrolled in the study group and their eyes were treated with topical citicoline three times a day for 1 month postoperatively. Seventy-eight eyes of 78 patients (mean age: 26.1 ± 7.4 years) were randomly selected as the control group and their eyes were treated with lubricant hyaluronic acid (0.15%) eye drops three times a day for 1 month. Corneal sensitivity was assessed in both groups using a Cochet-Bonnet esthesiometer at baseline and 1, 2, 3, 4, 6, 8, and 12 weeks after the LASIK procedure. Results: Corneal sensitivity at 1, 2, 3, 4, and 6 weeks after LASIK was significantly better in the citicoline group than the control group (P < .05 for all). Differences between the groups at 8 and 12 weeks after LASIK were not significant (P > .05). Conclusions: Topically administered citicoline eye drops had beneficial effects in the early recovery of corneal sensitivity during the first 6 weeks after LASIK, suggesting that citicoline may play a significant role in accelerating corneal reinnervation. Copyright © 2019 SLACK Incorporated.
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    Retinal and choroidal vascular changes in eyes with pseudoexfoliation syndrome: A comparative study using optical coherence tomography angiography
    (2020) Çınar, Esat; Yüce, Berna; Aslan, M. Fatih
    Background: Optical coherence tomography angiography allows a detailed evaluation of retinal and choroidal microvascular structures without the need for a contrast agent. Pseudoexfoliation syndrome is a condition that leads to anatomical and functional losses due to accumulation of degraded abnormal fibrillar material in the intraocular and extraocular tissues. Histopathological studies have shown that the accumulation of Pseudoexfoliation syndrome material in the vascular structures may play a role in different ocular pathologies such as retinal vein occlusion, iris hypoperfusion, anterior segment hypoxia, retinal arterial occlusion, and neovascular glaucoma. Aims: To evaluate and compare flow and vascular density in the retina and choroid in eyes with Pseudoexfoliation syndrome, fellow eyes without Pseudoexfoliation syndrome, and healthy eyes using optical coherence tomography angiography. Study Design: Case control study. Methods: The study included 35 eyes with Pseudoexfoliation syndrome of 35 Pseudoexfoliation syndrome patients, 32 fellow eyes without Pseudoexfoliation syndrome of 32 unilateral Pseudoexfoliation syndrome patients, and 35 eyes of healthy control subjects. Flow area and vascular density in the superficial capillary plexus and deep capillary plexus were measured by optical coherence tomography angiography as three separate parameters: total, parafoveal, and foveal. Choroidal thickness and foveal avascular zone area were measured for each patient. Results: There were significant differences between the Pseudoexfoliation syndrome eyes and control eyes in total, parafoveal, and foveal flow and vascular density in the superficial capillary plexus (p<0.05 for all), while there were no significant differences between these groups in any of the flow or vascular density values in the deep capillary plexus (p>0.05). None of the superficial capillary plexus and deep capillary plexus flow and vascular density values showed significant differences between Pseudoexfoliation syndrome eyes and non-Pseudoexfoliation syndrome fellow eyes or between the nonPseudoexfoliation syndrome fellow eyes and control eyes (p>0.05). Choroidal thickness was significantly lower in Pseudoexfoliation syndrome eyes compared to control eyes. Foveal avascular zone area was significantly enlarged in Pseudoexfoliation syndrome eyes compared to control eyes in both the superficial and deep layers (p<0.05). Conclusion: Pseudoexfoliation syndrome eyes exhibit significant damage to the retinal and choroidal vascular structures