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    Öğe
    Are Platelet-related Parameters Predictive of the Prognosis of Hodgkin's Lymphoma?
    (Galenos Yayincilik, 2021) Akdeniz, Aydan; Mehtap, Ozgur; Karakus, Volkan; Unal, Serkan; Aygun, Kemal; Temel, Gulhan Orekici; Tombak, Anil
    Objective: Hodgkin's lymphoma has a good prognosis unless it has relapsed or become refractory. The predictive value of platelet (Plt)-related parameters, namely, mean Plt volume (MPV), plateletcrit (PCT), Plt distribution width, and Plt, is shown in some solid tumors and hematological malignancies, but it remains unknown in Hodgkin's lymphoma. This study aimed to define their values and effects on staging and relapsing status in patients with Hodgkin's lymphoma by comparing them with those in healthy subjects. Methods: Values of Plt-related parameters of 217 patients with Hodgkin's lymphoma and 205 healthy individuals were documented and compared according to the disease stage and relapsing status. We defined the cutoff values for diagnosis, staging, and relapsing status of these parameters using the receiving operating characteristic curve analysis. Results: For diagnosis, the cutoff values of MPV, Plt, and PCT were 8.49 fL, 32,1000/mm(3), and 0.31, respectively. For staging, the cutoff values of MPV and Plt were 9.5 fL and 12 fL, respectively. None of the parameters were associated with relapsing status. Conclusion: This is the first study evaluating Plt-related parameters in Hodgkin's lymphoma. Further studies including survival analyses will clarify the effect of these parameters on Hodgkin's lymphoma.
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    Öğe
    Multiscale nano-integration in the scarf-bonded patches for enhancing the performance of the repaired secondary load-bearing aircraft composite structures
    (Pergamon-Elsevier Science Ltd, 2023) Serra, Topal; Al-Nadhari, Abdulrahman; Yildirim, Ceren; Beylergil, Bertan; Kan, Cihan; Unal, Serkan; Yildiz, Mehmet
    This study investigates a novel approach of improving the mechanical performance of scarf-repaired carbon fiber reinforced composites by integrating nanomaterials in the patch constituents. Two distinct types of carbon-based nanomaterials, thermally exfoliated graphene oxide grade-2 (TEGO) and Epocyl T 128-06 (MWCNT) are integrated into the patch resin matrix and fiber/matrix interface in an upscaled manner. Another group of composites are repaired with pristine patches in accordance with the existing and prevalent composite repair method. Compared to the reference panel, 109.9%, 99.7% and 99.3% stiffness recoveries are achieved for the patches with CNT and TEGO-incorporated resin matrices and TEGO-electrosprayed fibers, respectively. Location-wise analyses of the test data show that the stiffness, strength, Poisson's ratio, and strain values depend on the number of patch plies in each specimen. Fractographic inspections show that the failure sites shift towards the outer areas of the scarf region demonstrating an enhanced stress redistribution due to the nanomaterials. SEM observations show that nanoparticles affect toughening mechanisms based on the type, location, and alignment of the nano-reinforcement, which in turn limits the shear-dominated failures (SDF) in the baseline and pristine patch repair system. In CNT- and TEGO-reinforced resin patches, efficient crack bridging and fracture plane tilting/twisting or crack bifurcations are observed whereas the electrosprayed TEGO particles positioned at the perimeter of fibers operate as a shield for the fibers to prevent SDFs. These findings demonstrate that failure behavior of repair systems and therefore their mechanical performance are governed by the type of nanoreinforcement and its integration process.