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    B cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1? in GCF
    (Springer Heidelberg, 2022) Hatipoglu, Mukerrem; Daltaban, Ozlem; Ugur, Sevcan; Ustun, Kemal; Kacar, Cahit; Tuncer, Tiraje; Kantarci, Alpdogan
    Objectives We evaluated the effect of B cell depletion on the clinical periodontal findings and IL-1 beta and MMP-8 levels of the gingival crevicular (GCF) fluid in patients with rheumatoid arthritis (RA). Materials and methods Seventy patients were included in this case-control study. Twenty patients with RA were undergoing B-cell depletion treatment. The second group of RA patients (n= 20) were undergoing non-B-cell depletion treatment with Disease-Modifying Anti-Rheumatic Drugs (DMARD). Control group, with no RA, consisted of 30 individuals. Periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), and plaque index (PI) were recorded. IL-1 beta and MMP-8 levels in GCF were determined using enzyme-linked immunosorbent assay. Rheumatological parameters including Disease Activity Score-28 (DAS-28), rheumatoid factor levels (RF), and anti-cyclic citrullinated peptide levels were included in the data analyses. Results All groups were similar in PD, CAL, BOP, GI, and PI measures. GCF IL-1 beta levels were 1.85 +/- 1.67 pg in the B-cell depletion group, 10.50 +/- 13.16 pg in the DMARD group, and 34.12 +/- 29.45 pg in the control group (p < 0.001). MMP-8 levels were 21.00 +/- 4.23 pg in the B-cell depletion group, 8.16 +/- 6.94 pg in the DMARD group, and 21.45 +/- 8.67 pg in the control group (p < 0.001). DAS 28, RF, and anti-CCP were similar in RA groups. Conclusions GCF IL-1 beta levels were significantly lower in B cell depletion group, and MMP-8 levels were significantly lower in DMARD group, suggesting that rheumatoid arthritis treatments may modify biochemical parameters of GCF.
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    Öğe
    Low vaccination rates and awareness status in patients with rheumatoid arthritis: a nationwide cross-sectional survey study
    (Springer Heidelberg, 2025) Kirik, Ali; Sahin, Nilay; Baykul, Merve; Bodur, Hatice; Guler, Tuba; Cevik, Remzi; Ugur, Sevcan
    To examine the pneumococcal, haemophilus influenza, hepatitis A virus (HAV), and hepatitis B virus (HBV) vaccine rates and and predictors of vaccination among a T & uuml;rkiye population of rheumatoid arthritis (RA) patients. In this multicenter, cross-sectional study, vaccination levels and related factors were questioned by face-to-face survey method during routine clinical examination of patients with RA followed in different regions of T & uuml;rkiye. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) software package, version 26. A total of 715 patients (mean age 53.1 +/- 13 years), of whom 552 (77.2%) were women, were included in this study. The rate of vaccine awareness education in the whole patient group was 40.1%. The vaccination rates for influenza, pneumococcal, HAV, and HBV were 34.3%, 21.8%, 12.3%, and 28.5%, respectively. It was noteworthy that the level of vaccine awareness education was a positive predictive factor affecting vaccination in all vaccine types (p < 0.001, for all vaccine types). The rates of low income were higher in the vaccinated group for pneumococcal (p < 0.001) and haemophilus influenza (p = 0.011) vaccine than in the unvaccinated group. The participants with living in a rural area were significantly higher in the unvaccinated group for HAV and HBV vaccine than in the vaccinated group (p < 0.001). The frequency of less than two medical visits per year was significantly higher in the unvaccinated group for pneumococcal (p < 0.014) and haemophilus influenza (p < 0.001 ) and HBV vaccine (p = 0.009) than in the vaccinated group. multivariate analysis found that rural area (for Haemophilus influenza and HAV vaccines) and financial income (Pneumococcal vaccine) in specifically were associated with increased vaccination rates (p < 0.001). Additionally, the rate of vaccination education was significantly higher in the vaccinated group for all vaccine types, which is noteworthy as a result of the positive effect of education on vaccination (p < 0.001). Vaccination awareness education and rates are low in primary prevention for RA patients. Vaccination awareness training is important in increasing the level of vaccine rates.