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    Does cerebrospinal fluid IL-17F distinguish normal pressure hydrocephalus from dementia?
    (2024) Karabörk, Şeyda; Çelik, Hümeyra; Turkoglu, Sule Aydin
    Aim: The neurological disorder known as normal pressure hydrocephalus (NPH), which has an unknown cause, may be treatable, and is defined by a clinical triad of symptoms. A phenomenon known as dementia refers to a decline in cognitive performance that goes beyond what may be anticipated from the typical effects of biological aging. The symptomatic similarity between these two diseases causes problems in diagnosis. The objective of our study was to compare the concentrations of IL-17A, IL-17F, IL-34, and CXCL13 in the cerebrospinal fluid (CSF) of patients with NPH and dementia for an informative laboratory diagnosis. Methods: The study included NPH and dementia cases (n=7, n=5, respectively) taken from the patients’s CSF sample by lumbar puncture (LP). The levels of IL-17A, IL-17F, IL-34, and CXCL13 were measured in the CSF of patients' with NPH and dementia by enzyme-linked assay (ELISA) and compared between the two different groups. Results: There was no difference in age between the NPH and dementia groups (p=0.5). There was no statistically significant difference was found in IL-17A (p=0.7), IL-34 (p=0.9), and CXCL13 (p=0.2) in the inflammatory marker analysis in the CSF. The groups had a statistically significant difference in IL-17F (p=0.04). Conclusion: IL-17F can be an important laboratory marker used in the differential diagnosis of NPH and dementia.
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    Öğe
    Is increased activator protein 1 in cerebrospinal fluid as a potential biomarker that distinguishes idiopathic intracranial from sclerosis?
    (Aepress Sro, 2024) Karabork, Seyda; Celik, Humeyra; Dursun, Ali Dogan; Ankarali, Handan; Turkoglu, Sule Aydin
    OBJECTIVES: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein -1 (AP -1) was evaluated with its potential to differentiate both diseases. BACKGROUND: The aim of this study was to investigate the use of AP -1 as biomarkers for the discrimination of IIH and MS. METHODS: AP -1, TNF-alpha, and IL -6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP -1 to distinguish the groups were analyzed with the ROC curve. RESULTS: There was no difference between the groups in CSF TNF-alpha, IL -6, CSF, and serum biochemistry analyses. However, it was determined that the AP -1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP -1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP -1 concentration of 606.5 and above. CONCLUSION: According to our results, the fact that CSF TNF-alpha and IL -6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP -1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31) . Text in PDF www.elis.sk