Yazar "Tumer, Mehmet Kemal" seçeneğine göre listele

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    A Bibliometric Analysis of International Publication Trends in Total Temporomandibular Joint Replacement Research (1986-2020)
    (W B Saunders Co-Elsevier Inc, 2021) Balel, Yunus; Tumer, Mehmet Kemal
    Purpose: To conduct a bibliometric analysis that systematically characterizes publications on temporo-mandibular joint temporomandibular joint replacement from 1986 to 2020. Materials and Methods: The articles were retrieved on the same day from the Web of Science Core Collection database of the Web of Science on December 31, 2020 to prevent bias due to daily database updates. Excel 2016, CiteSpace IV, and VOSviewer v1.6.16 were used for analysis. Results: A sum of 610 publications from 1986 to 2020 were analyzed. The highest number of publi-cations were identified and published in the Journal of Oral and Maxillofacial Surgery. The United States had the highest number of publications and the highest H-index. The highest co-citations were from Mercuri. Conclusions: In this study, developments, the most influential publications, journals, and countries in the field of temporomandibular joint temporomandibular joint replacement were determined based on evidence through bibliometric analysis. (C) 2021 Published by Elsevier Inc. on behalf of the American Association of Oral and Maxillofacial Surgeons.
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    Can Mecsina Hemostopper, which has a Cytotoxic Effect on Mcf-7 Cells, be Considered an Anticarcinogenic Agent due to its Immunological Properties?
    (2024) Cicek, Mustafa; Tumer, Mehmet Kemal; Turgut, Alpgiray
    Aim: Mecsina is used as a hemostatic agent such as Ankaferd and Tranexamic acid. To struggle with breast cancer, which is a serious public health issue, new, effective, and less toxic therapeutic agents are needed. Hence, it is aimed to compare and evaluate the effects of Mecsina and Ankaferd, both of which contain natural biomolecules in their structure, and synthetic Tranexamic acid on MCF-7 cells. Material and Method: For this study, MCF-7 immortalized cell lines were commercially purchased. The cells, 5000 cells per flask for each different dose group, were distributed to the 9 groups (mecsina 1:1, 1:2, 1:10, 1:50, 1:100, 1:200, 1:500, distilled water administered negative and control without any administration). Cytotoxicity, ELISA cytokine levels were evaluated, and flow cytometric analyzes were performed for each group using the XTT analysis method, after 24 hours of incubation. Results: A significant difference was observed between different doses of drug administration groups of Mecsina Hemostopper hemostatic agent in MCF-7 cells (p<0.001). Besides, cytokine levels were found to be significantly higher than those of other possible therapeutic agents. Conclusion: Mecsina Hemostopper has been found to have anti-tumoral activity in MCF-7 cancer cell lines by producing a hemostatic effect.
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    Does Temporomandibular Joint Magnetic Resonance Imaging Diagnosis Support Clinical Examination Diagnosis Following Diagnostic Criteria for Temporomandibular Disorders?
    (W B Saunders Co-Elsevier Inc, 2023) Balel, Yunus; Yildiz, Serkan; Gokce, Erkan; Tumer, Mehmet Kemal; Ege, Bilal
    Purpose: The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) has been validated as a clinical diagnostic guideline with high-sensitivity and -specificity in identifying TMDs. The purpose of this study was to evaluate the agreement between DC/TMD diagnoses and magnetic resonance imaging (MRI) diagnoses in patients with TMD. Methods: A prospective cohort study was conducted on patients with TMD. The predictor variable was the clinical diagnosis of TMD based on DC/TMD criteria. The outcome variable was the MRI diagnosis of TMD. The diagnoses used for both the predictor variable and the outcome variable were the same. They were normal, disc displacement with reduction (DDWR), DDWR with intermittent locking, disc displacement without reduction (DDWOR) with limited opening, DDWOR without limited opening, degenerative joint disease, and subluxation. Age and gender of the patients and number of joints evaluated were covariates. Each subject had clinical examination performed by two independent Oral and Maxillofacial Surgeons. All subjects had a bilateral temporomandibular joint (TMJ) MRI performed which was evaluated by a radiologist. The correlation between the clinical and MRI diagnoses was calculated using Cohen's kappa value with a P value of <.05 considered significant. Results: A total of fifty patients (100 TMJs) were enrolled with 38 females and 12 males. The mean ages were 31.92 and 31.75 years, respectively, with a total of 100 TMJs analyzed. Internal derangement was clinically identified in 76% of the joints and with MRI in 69% of joints. The Cohen's kappa value between DC/TMD and MRI diagnoses was found to be kappa = 0.720 (P < .01). The respective sensitivity and specificity in determining disc position clinically for DDWR was 1 and 0.96; for DDWR with intermittent locking 0.78 and 0.91; for DDWOR with limited opening 0.9 and 0.98; for DDWOR without limited opening 1 and 0.9; for degenerative joint disease 0.63 and 0.97 and for subluxation 0.28 and 1.00. Conclusion: The DC/TMD clinical examination performed well in all types of disc displacement but is less reliable than MRI in detecting the presence of degenerative disc diseases and subluxation. (C) 2023 American Association of Oral and Maxillofacial Surgeons
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    Evaluation of prevalence of temporomandibular disorders based on DC/TMD Axis I diagnosis in Turkish population and correlation with Axis II
    (Elsevier, 2023) Yildiz, Serkan; Balel, Yunus; Tumer, Mehmet Kemal
    Purpose: The prevalence of DC / TMD diagnosis of individuals with internal derangement of TMJ who want to receive TMD treatment in a tertiary clinic in the Turkish population and comparison of the criteria applied in Axis I and Axis II. Methods: This study was carried out on 200 individuals older than 18 years of age who have internal disorder of Temporomandibular Joint (TMJ). Diagnostic Criteria for Temporomandibular Disorders (DC / TMD) Axis I and II were applied. Results: The female to male ratio of individuals with internal derangement of TMJ in the Turkish population was 3.5. The Pearson correlation coefficient between the internal derangement of the Right TMJ and the internal derangement of the Left TMJ is 0.804 and has a statistically significant relationship (p <0.05). Conclusions: For DC / TMD, a more comprehensive study is needed to compare the results found in the Turkish population with other populations. (c) 2022 Published by Elsevier Masson SAS.
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    Evaluation of the effects of arthrocentesis combined with occlusal stabilization splint on disc displacement without reduction-induced acute and closed lock. A prospective cohort study
    (Elsevier, 2023) Erdil, Aras; Demirsoy, Mustafa Sami; Tumer, Mehmet Kemal
    Objective:Disc displacement without reduction (DDWoR) of the temporomandibular joint is associated with limited mouth opening and arthralgia. In the natural course of the disorder, there is a tendency to progress to degenerative joint diseases. First-line treatment aims to reduce pain and restore joint function. The current study aims to examine the efficacy of an occlusal stabilization splint applied simultaneously with arthrocentesis as first-line treatment in acute and chronic closed-locks.Materials and methods:The present prospective clinical trial included 40 patients who were diagnosed with DDWoR induced chronic (Group 1, n = 23) and acute (Group 2, n = 17) closed-locks. All participants underwent single session arthrocentesis and were applied occlusal stabilization splints. Maximum mouth opening amounts (MMO), Visual analogue scale (VAS), and McGill pain questionnaire (MPQ) scores were evaluated at baseline, on the operation day, and on seven days after the intervention. The obtained data was analyzed with the Wilcoxon signed-rank, Mann-Whitney U, Fisher's exact, Spearman's correlation tests.Results:According to the baseline data, a significant increase was observed in the amount of MMO in postoperative measurements (p = 0.001 and p < 0.001). A statistically significant decrease in MPQ scores was observed in the postoperative period (p < 0.001 and p < 0.001). While a significant difference was observed between the postoperative VAS scores, the scores of Group 2 were lower (p = 0.018).Conclusion: Although combined arthrocentesis and occlusal stabilization splint provided significant changes for acute and chronic closed-locks in line with first-line treatment goals, acute closed-lock with arthralgia responded better.(c) 2023 Elsevier Masson SAS. All rights reserved.
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    Evaluation of the Efficacy of Auriculotemporal Nerve Block in Temporomandibular Disorders
    (Mre Press, 2021) Demirsoy, Mustafa Sami; Erdil, Aras; Tumer, Mehmet Kemal
    Aims: To investigate the effectiveness of the auriculotemporal nerve block (ATNB) technique in conjunction with noninvasive therapies for the treatment of disc displacement with reduction (DDWR) or without reduction (DDWOR) in addition to arthralgia of the temporomandibular joint (TMJ). Methods: The data of 22 patients diagnosed with DDWR and DDWOR whose clinical conditions did not improve despite noninvasive treatments were analyzed. ATNB was applied to each patient during the first visit and readministered at 1- and 4-week follow-up visits. Pain intensity values (0 to 10 visual analog scale [VAS] scores) were evaluated pre-ATNB and at the 6-month follow-up visit, and the maximal mouth opening values were measured pre-ATNB and at the 1-week, 4-week, and 6-month follow-up visits. Results: Noninvasive therapies did not make a significant difference in the outcomes between the initial visit and first administration of ATNB (VAS P = .913, MMO P = .151). However, there were significant differences in outcomes between pre-ATNB and the 1-week (MMO P = .000), 4-week (MMO P = .000), and 6-month (VAS P = .027, MMO P = .000) follow-ups. Conclusion: ATNB may be considered as a supportive treatment approach in noninvasive TMJ disorder therapies.
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    Evaluation of the Impacts of Surgical Removal of Impacted Teeth on Alterations of the Mood with Beck Depression Inventory
    (2022) Demirsoy, Mustafa Sami; Erdil, Aras; Çolak, Sefa; Tumer, Mehmet Kemal
    Objectives To determine whether the inflammatory complications following impacted third molar surgeries and varying surgical difficulties impact individuals' mood alterations. Materials and Methods A prospective, double-blind, observational study was designed with three study groups (slightly, moderate, and very difficult) constituted with surgical difficulty scores. The participants were evaluated preoperatively and postoperatively on the sixth hour, second and seventh days. The visual analog scale (VAS) and Beck depression scale (BDS) scores, maximal mouth opening, and swelling amounts were recorded. Results A total of 75 patients were enrolled and divided into three study groups with an equal number of participants. The preoperative mean BDS scores of the study groups (slightly, moderate, very difficult) were 9.16, 7.16, and 8.12, and mean VAS scores were 2.86, 1.4, and 1.56, respectively. A significant correlation was observed between the surgical difficulty and the increased BDS scores on the second and seventh postoperative days (p=0.031, p=0.001). Significant correlations were observed between surgical difficulty and VAS scores (p=0.018) and maximum mouth opening amounts (p=0.021) on the second postoperative day. Also, postoperative swelling amounts were significantly affected by surgical difficulty on the postoperative second day (p=0.007). The impact of surgical difficulty and inflammatory complication-related factors on the postoperative BDS scores' increase was also evaluated, and the postoperative pain, trismus, swelling, and operation time correlated. Conclusion The surgical removal of impacted molar teeth has significant effects on alterations in mood. It would be beneficial to consider different aspects of the postoperative term that the patient will experience in third molar surgeries.
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    Role of VEGF I/D variant in suspectibility to odontogenic cyst formation
    (Taylor & Francis Inc, 2023) Yildiz, Serkan; Nursal, Ayse Feyda; Yigit, Serbulent; Tumer, Mehmet Kemal
    Odontogenic cysts, are located in the jawbones, filled with fluid surrounded by epithelial lining and fibrous connective tissue. Vascular endothelial growth factor (VEGF) can induce physiological and pathological angiogenesis and is an endothelial cell-specific mitogen. The aim of the present study was to investigate whether any possible association between the VEGF insertion/deletion (I/D) variant and odontogenic cyst in Turkish population. Clinical information and venous blood samples were collected from 62 odontogenic cyst patients and 98 healthy controls. DNA was isolated from peripheral blood leukocytes. Genotyping of the VEGF I/D variant was done by the polymerase chain reaction (PCR) method. There was a statistically differece in terms of VEGF I/D allele frequencies between patients and controls. VEGF I/D variant I allele frequency was more prevalant in patients compared to controls (p = 0.006411, OR: 2.08, 95%Cl: 1.322-3.272). A statistically significant association was observed when the patients were compared with the controls according to D/D + I/D versus I/I genotype (p = 0.0508, OR: 1.925, 95%Cl: 0.872-4.246). The genotype distribution of VEGF I/D was not statistically different between patients and controls (p > 0.05). For the first time, our results provided evidence supporting the odontogenic cyst formation associated with the I/D variant at the promoter region of the VEGF gene in a group of Turkish population. Although it was seen in our study that the I/D variant in the promoter region of the VEGF gene supports odontogenic cyst formation, large-scale studies are needed to elucidate the effect of this variant on odontogenic cysts.
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    The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients
    (2023) Tumer, Mehmet Kemal; Keskin, Adem; Aci, Recai; Yigit, Serbulent
    Objective: Odontogenic cysts that cause bone destruction can exhibit various types of metaplasia. Inherited genetic variants in codons 72 and 175, the hotspot codons of p53, known as the guardian of the genome, can cause a wide variety of cancers. We aimed to investigate the effects of the p53 codon 72 and p53 codon 175 variants on odontogenic cyst formation. Methods: This research encompassed 71 individuals with odontogenic cysts and 90 without any conditions as a control group. After DNA was extracting, the p53 codon 72 was detected using PCR techniques, while p53 codon 175 was identified through allele-specific amplification-PCR. Results: The presence of the p53 codon 72 GG genotype and its G allele was less frequent in the group with odontogenic cysts compared to the healthy participants. Conversely, the C allele was found more often in the cyst-afflicted group. For the p53 codon 175, the AA genotype and A allele were more common in the affected group, while the G allele was more predominant in the control group. Conclusion: The p53 codon 175 AA genotype and A allele, p53 codon 72 C allele, and p53 codon 72/codon 175 CCAA combined genotype may be associated with odontagenic cyst formation. Individuals with this allele and genotype can be considered at risk for odontagenic cyst formation.
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    The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients
    (Pera Yayincilik Hizmetleri, 2023) Tumer, Mehmet Kemal; Keskin, Adem; Aci, Recai; Yigit, Serbulent
    Objective: Odontogenic cysts that cause bone destruction can exhibit various types of metaplasia. Inherited genetic variants in codons 72 and 175, the hotspot codons of p53, known as the guardian of the genome, can cause a wide variety of cancers. We aimed to investigate the effects of the p53 codon 72 and p53 codon 175 variants on odontogenic cyst formation. Methods: This research encompassed 71 individuals with odontogenic cysts and 90 without any conditions as a control group. After DNA was extracting, the p53 codon 72 was detected using PCR techniques, while p53 codon 175 was identified through allele-specific amplification-PCR. Results: The presence of the p53 codon 72 GG genotype and its G allele was less frequent in the group with odontogenic cysts compared to the healthy participants. Conversely, the C allele was found more often in the cyst-afflicted group. For the p53 codon 175, the AA genotype and A allele were more common in the affected group, while the G allele was more predominant in the control group. Conclusion: The p53 codon 175 AA genotype and A allele, p53 codon 72 C allele, and p53 codon 72/codon 175 CCAA combined genotype may be associated with odontagenic cyst formation. Individuals with this allele and genotype can be considered at risk for odontagenic cyst formation.
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    The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
    (2024) Yildiz, Serkan; Yigit, Serbulent; Nursal, Ayse Feyda; Karakus, Nevin; Tumer, Mehmet Kemal
    Background: Temporomandibular joint disorder (TMD), a set of conditions that affect the temporomandibular joint and related structures, is frequently linked to bruxism. The vitamin D receptor (VDR) affects calcium absorption, bone remodeling, and mineralization rate. The goal of this study was to evaluate the role of the VDR Bsm1 (rs1544410) variant in the susceptibility to bruxism in TMD. Method: A total of 321 people [221 TMD patients (135 with bruxism and 86 without bruxism) and 100 healthy controls] were included in the study. The VDR Bsm variant was genotyped using the PCR-RFLP method. Results: We found no significant difference between the all-TMD patient group and the control group regarding the VDR Bsm1 genotype and allele distribution (p>0.05). There was no deviation from HWE for the VDR variant in groups. There was no relationship between pain characteristics and VDR Bsml genotype distribution in patients with bruxism. Conclusions: Our results support the conclusion that the VDR Bsm1 variant is not a risk factor for the development of bruxism in TMD. The effect of the VDR Bsml variant on the risk of bruxism in TMD should be investigated in studies involving larger populations and other ethnicities.