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    Predictive ability of liver-fatty acid binding protein for all-cause mortality in patients with hepatic encephalopathy: A prospective observational study
    (2018) Çakır, Özlem Özer; Toker, Aysun; Ataseven, Hüseyin; Demir, Ali; Polat, Hakkı; Güngör, Gökhan; Bıyık, Murat
    Purpose: We investigated the ability of serum and urine Liver-Fatty Acid Binding Protein levels to predict mortality in patients with hepatic encephalopathy and/or compensated cirrhosis. Materials and methods: We enrolled 48 patients with cirrhosis (19 hepatic encephalopathy, 29 compensated cirrhosis) and 20 control individuals. Serum and urine Liver-Fatty Acid Binding Protein levels were determined. Patients were prospectively followed for three months. Results: Cox regression analyses showed that urine liver- fatty acid binding protein levels, Model for End-Stage Liver Disease-Sodium scores, and Child-Turcot-Pugh scores were independent predictors of mortality. Receiver operating characteristic curve analyses showed that serum levels of liver- fatty acid binding protein (>8057.5 ng/L), urine liver-fatty acid binding protein (>9892.5 ng/L), and ammonia (>65.5 µg/dL), as well as the Model for End-Stage Liver Disease-Sodium (>21.5) and Child-Turcot-Pugh (>10.5) scores, predict mortality in patients with hepatic encephalopathy. Similarly, the areas under the curve for serum liver-fatty acid binding protein (AUC, 0.701), urine liver- fatty acid binding protein (0.692), and serum ammonia (0.898) levels, as well as Model for End-Stage Liver Disease-Sodium (0.934) and Child-Turcot-Pugh (0.966) scores predicted mortality in patients with hepatic encephalopathy. Conclusion: Liver-Fatty Acid Binding Protein levels predict mortality in patients with hepatic encephalopathy.