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    Evaluation Of Red Cell Distribution Width In Children With Hypertension
    (Springer, 2024) Gokceoglu, Arife Uslu; Bodu, Nuriye; Tas, Nesrin
    [Abstract Not Available]
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    Öğe
    Red cell distribution width and related indices in relation to target-organ damage in children with hypertension
    (Bmc, 2025) Uslu Gokceoglu, Arife; Tas, Nesrin; Boduc Bolu, Nuriye
    Background The purpose of this paper is to examine the relationship between target organ damage in children with primary hypertension and red cell distribution width (RDW) and related indices to elucidate their potential clinical implications. Method A cross-sectional retrospective study was conducted on data collected from patients with primary hypertension. Demographic variables, body mass index (BMI), hemoglobin, RDW, leukocyte count, platelet count and albumin results were recorded. RPR was defined as the ratio of RDW to platelet count and RAR was defined as the ratio of RDW to albumin. A comprehensive evaluation was conducted on all patients to ascertain the presence of target organ damage. This evaluation included echocardiography, retinal examination, and urine analysis. Results The study included 219 hypertensive children and 57 healthy controls. The majority of patients were male (61.6%) and had elevated BMI (69.4%). Overall, 45.7% had left ventricular hypertrophy (LVH), 5.5% had hypertensive retinopathy and 4.5% had proteinuria. The mean RDW level in patient group was higher than that of controls (13.1 +/- 0.9% and 12.8 +/- 0.7%, p < 0.05). The mean RDW level and RPR in children with LVH were higher than that of children without LVH (respectively, 13.3 +/- 1% and 13 +/- 0.7, p < 0.05 and 0.048 +/- 0.012 and 0.044 +/- 0.010, p < 0.01). An elevated white blood cell count was observed in children with a high BMI. However, the mean RDW and RAR values remained comparable. The RPR value was found to be higher in the patients with normal BMI. The male gender was identified as a significant risk factor for LVH. Conclusion Elevated RDW and RPR levels were associated with LVH in hypertensive children, suggesting their potential role as markers of target organ damage, whereas RAR showed limited utility. Male gender emerged as an independent risk factor for LVH. Obese children demonstrated higher leukocyte counts, indicating a link between obesity and systemic inflammation. However, RDW and RAR did not vary with BMI, and unexpectedly, RPR was higher in children with normal BMI. These findings suggest that hematological parameters may provide insights into both cardiovascular risk and obesity-related changes in pediatric populations.
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    Öğe
    Renal scarring in children with febrile urinary tract infection
    (Soc Brasil Pediatria, 2025) Gokceoglu, Arife Uslu; Tas, Nesrin
    Objective: The authors aim to evaluate characteristics of children with fUTI and results of renal bladder ultrasonography (RBUS) and late dimercaptosuccinicacid (DMSA) scan. Methods: This study is designed as retrospective analysis of RBUS and DMSA reports of children with fUTI. Age, gender, number of fUTI, presence of constipation and vesicouretheral reflux (VUR) were recorded. Results: The study included 160 children with fUTI with a median age of 7 years (6 months 18 years old). The majority of children in this study were girls (86.3 %), older than 60 months (73.1 %) and had one episode of fUTI. The recurrence rates of UTI were similar in both girls and boys. The total rate of constipation was 21.9 %. The rate of renal scarring on DMSA was 16.9 %. The rates of renal scarring were similar at three age groups and both genders. The rate of renal scarring was higher in children with recurrent UTI compared to those with one episode of fUTI (26.4 % and 12.5 %, respectively; p = 0.04). The rate of constipation in children with renal scarring and normal DMSA was similar (p = 0.07). The rate of trabeculation and thick bladder wall was higher in children with renal scarring at DMSA than children with no renal scarring (p = 0.03). Conclusion: The present study demonstrated that 16.9 % of children with fUTI had renal scarring. The rates of renal scarring were similar in both gender and age groups. Children with recurrent UTI and abnormal bladder results at RBUS had higher rates of renal scarring. (c) 2024 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).