Yazar "Sevil, Ergün" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Efficiency of resveratrol in the prevention and treatment of age-related hearing loss
    (2022) Müderris, Togay; Yar Sağlam, Atiye Seda; Ünsal, Döndü; Mülazimoğlu, Selçuk; Sevil, Ergün; Kayhan, Handan
    Age?related hearing loss (ARHL) is a major public health concern, which is characterized by gradual, progres? sive sensorineural hearing loss and deterioration of sound localization, with no effective treatment available to date. The aim of the present study was to evaluate the efficacy of resve? ratrol to prevent and treat ARHL. For this purpose, 32 male C57BL/6 mice were assigned to four groups: Early treatment, late treatment, control and sham control. The experiment lasted for 15 months. Treatment was started at three months of age in the early treatment group and at sixth months in the late treatment group. The auditory brainstem response test was performed once every three months. At the end of the study period, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)?2, NF??B, Bcl?2, Bcl?xL, Bax, Bcl?2 homologous antagonist/killer (Bak), caspase?3 and caspase?9 levels in the cochlear tissues of the animals were analyzed by reverse transcription?quantitative PCR. Hearing thresholds of the mice in the early treatment group were better than those in the other groups (P<0.001) at the end of the study. However, hearing levels in the late treatment group were not significantly different from those in the control groups (P>0.05), although mean thresholds were lower. The threshold shift in the early treatment group was significantly lower at all frequencies when compared with those in the control groups (P<0.001). The mRNA expression levels of pro?apoptotic genes Bax and Bak were lower (P<0.05), anti?apoptotic genes Bcl?2 and Bcl?xL were higher (P<0.05), NF??B, COX?2 and iNOS as genes that have a role in inflammation and caspase?3 and caspase?9 as genes with a vital role in apoptosis were lower (P<0.05) in the early treatment group when compared with the late treatment and control groups. These results suggested that resveratrol is effective in the prevention of ARHL, particularly when started prior to the beginning of hearing loss.
  • [ X ]
    Öğe
    Programming the auricle
    (Springer International Publishing, 2023) Sevil, Ergün; Cingi, Cemal; Milkov, Mario
    The incidence rate of ear abnormalities in neonates is between 15 and 50%. [1]. Mental anguish might result from an odd auricular appearance [2]. Evidence suggests that children born with ear abnormalities are more likely to struggle with anxiety, low self-esteem, and relationship issues [3]. As a result, correcting ear abnormalities is crucial for the emotional well-being of kids [3, 4]. © Springer Nature Switzerland AG 2023. All rights reserved.
  • [ X ]
    Öğe
    Tinnitus: Overview
    (Springer Science+Business Media, 2025) Celik, Elif Kaya; Sevil, Ergün; Cingi, Cemal
    One symptom of tinnitus is a persistent ringing or buzzing in the ears or head. A ringing sound, the Latin word “tinnire” is the origin of the English word tinnitus. It is common for people to hear the sound even when there are no other sounds around, and this impression is independent of any outside force. Objective tinnitus is a sound that others can hear, but subjective tinnitus only the patient hears. The sound of a gunshot or a loud concert, especially one with current sound equipment, can leave many people with ringing in the ears. Although this form of tinnitus is bothersome, it typically disappears after a few hours. Because it is a symptom and not an illness, tinnitus indicates something is wrong. While sensorineural hearing loss is the most common cause of tinnitus, other forms, such as pulsatile, vertigo-accompanied, fluctuating, or unilateral tinnitus, need further investigation. © 2025 Springer Nature Switzerland AG.