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    Cognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity
    (Cell Press, 2025) Yulug, Burak; Yalcinkaya, Ali; Safa, Shair Shah; Karakus, Ayse; Sayman, Dila; Cankaya, Seyda; Sayman, Ceyhun
    Tension-type headache (TTH) is a widespread primary headache disorder that causes mild to moderate pain, which may be seen together with cognitive deficits. It is unclear if TTH-linked cognitive impairment is associated with functional alterations. Seventy-five participants were enrolled in the study. Mini Mental State Evaluation (MMSE) and Montreal Cognition Assessment (MoCA) tests were applied to evaluate cognitive impairment. A neuroimaging analysis was applied to determine whether the hippocampus responsible for pain and cognition was affected in TTH patients. Our functional data revealed significant alterations in the connectivity of the subiculum, hippocampal fissure, and left whole hippocampus. Among the significant functional brain alterations observed, the right subiculum consistently interacted with MoCA scores and increased pain intensity. Our findings suggest that TTH patients with cognitive impairment may exhibit unique functional alterations in the hippocampus. This suggests a potential negative association between pain modulation and cognitive processes in the hippocampus that may be responsible for the increased risk of dementia in these patients.
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    Emotional Burdens and Cognitive Decline: the Role of Anxiety in Mild Cognitive Impairment
    (Kafkas Üniversitesi, 2025) Sayman, Ceyhun; Aylak, Uğur; Çankaya, Şeyda; Yuluğ, Burak
    Aim: This study investigates the complex interactions between mild cognitive impairment (MCI), depression, and anxiety, focusing on how these factors affect cognitive function and progression risks. The goal is to inform early diagnostic strategies and targeted therapeutic interventions in individuals with MCI Matherial and Methods: This prospective study included 45 patients diagnosed with MCI (mean age: 66.1±7.7 years; 23 males [51%], 22 females [49%]) at a neurology outpatient clinic. Sociodemographic data, including education level and medical history, were collected. Cognitive and psychiatric assessments were conducted using the Montreal Cognitive Assessment (MoCA), Standardized Mini-Mental State Examination (SMMT), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Scale (HAS). Stratification was done according to anxiety severity, and comparisons were made across these groups on the cognitive performances. Results: Anxiety levels were significantly higher in females than males (p=0.001). While global MoCA and SMMT scores did not differ significantly by gender, males showed significantly better performance in verbal fluency (p=0.025) and a trend in abstract thinking (p=0.057). A significant decline in MoCA total scores was observed with increasing anxiety severity (p=0.024), with verbal fluency (p=0.011), abstract thinking (p=0.005), and attention (p=0.050) notably affected in the severe anxiety group. Conclusions: This study highlights anxiety as a key modifiable risk factor for cognitive impairment in MCI, with domain-specific deficits in executive function. Unlike depression, anxiety showed a stronger correlation with cognitive decline. These findings suggest that early identification and targeted treatment of anxiety in MCI could help delay progression to dementia and improve clinical outcomes.
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    Öğe
    High dose corticosteroid causes bradycardia in patients with multiple sclerosis
    (Wiley, 2024) Sayman, Ceyhun; Celik, Humeyra; Cankaya, Seyda; Oktem, Ece Ozdemir; Yulug, Burak
    [Abstract Not Available]
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    Öğe
    Migren Yönetiminde Unilateral Büyük Oksipital Sinir Blokajının Etkinliği: Hedefe Yönelik Yaklaşım
    (Alanya Alaaddin Keykubat University, 2025) Sayman, Ceyhun; Bayır, Buse Hasırcı; Gürsoy, Gizem; Şahin, Kerim; Çetinkaya, Yılmaz
    Amaç: Migren hem bireysel açıdan hem de halk sağlığı perspektifinden büyük acılara neden olan en yaygın ve engelleyici nörolojik bozukluklardan biridir. Hastalar, genellikle ağızdan alınan tedavilerin ya etkinlik eksikliği ya da yan etkileri nedeniyle sıkıntı yaşamaktadır. Son zamanlarda, Büyük oksipital sinir (greater occipital nerve- GON) blokajı migren tedavisinde potansiyel bir seçenek olarak öne çıkmıştır. Bu çalışma, bu nedenle, migren tedavisinde tek taraflı GON blokajını değerlendirmiştir. Yöntem: Bu prospektif çalışmaya toplam 35 migren hastası dahil edilmiştir. Başlangıçta ve GON blokajı tedavisinden sonra 1 hafta, 1 ay ve 3 ayda baş ağrılarının sıklığı, süresi, ağrı şiddeti ve analjezik kullanımını değerlendirilmiştir. Birincil sonuç ölçütleri, migren ataklarının sayısındaki, süresindeki ve görsel analog skala (visual analogue scale- VAS) kullanılarak ölçülen ağrı şiddetindeki değişiklikleri içermektedir. Bulgular: Migren ataklarının ortanca sayısının başlangıçta 12'den 3. aya kadar üçe düştüğü görülmüş ve anlamlı bir azalma gösterilmiştir (p=0.007). Migren ataklarının başlangıçtaki ortalama süresi 12 saatten 3. ayda 3 saate düşmüş (p < 0.0001) ve başlangıçtaki ortalama VAS skoru 10'dan 3. ayda 4'e iyileşmiştir (p < 0.0001). Ayrıca, alınan analjezik ilaç sayısı da başlangıçtaki 12 iken, 3. ayda 2’ye gerilemiştir (p=0.005). Sonuç: Sonuçlarımız, migren hastaları için tek taraflı GON blokajının, baş ağrısı sıklığını, şiddetini ve süresini önemli ölçüde azaltan etkili ve iyi tolere edilen bir müdahale olduğunu göstermektedir.
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    Öğe
    QSM-Based Evidence of Brain Iron Accumulation in THAP1 Dystonia with Biallelic Mutation
    (Wiley, 2025) Tarhan, Gullu; Kamaci, Ibrahim; Dusek, Petr; Capan, Nalan; Sayman, Ceyhun; Turan, Cagla; Ugur Iseri, Sibel Aylin
    [Abstract Not Available]
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    Öğe
    Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region
    (Springernature, 2025) Yulug, Burak; Yalcinkaya, Ali; Safa, Shair Shah; Sayman, Dila; Cankaya, Seyda; Karakus, Ayse; Sayman, Ceyhun
    Depressive cognitive impairment is seen in a significant number of patients with depression. However, it remains challenging to differentiate between patients with amnestic (those with subjective cognitive impairment complaints) and non-amnestic major depressive disorder, highlighting the urgent need for additional objective tools to help classify these patients more accurately. We analyzed cognitive state, alterations in regional entropy and functional connectivity measures of the brain between patients with major depression and healthy controls. The depressed cohort was categorized as either amnestic or non-amnestic, depending on self-reported experiences of forgetfulness. The superior temporal region and insula exhibited altered entropy and connectivity measures in individuals with depression and subjective cognitive impairment, which was correlated with impaired executive functions, a pattern not being evident in the control group. Our findings support the notion that insular and superior temporal entropic alterations are linked to subjective cognitive changes in the pathology of depression. These regions also hold potential as biomarkers for determining the underlying objective cognitive deficits in subjective cognitive complaints in patients with major depressive disorder (MDD). This underscores the need for improved diagnostic approaches and the implementation of practical dynamic neuroimaging modalities capable of addressing the current challenges in diagnosing subjective cognitive impairment in MDD, offering promise for the future management of patients with depression.