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    Congenital analbuminemia in unrelated algerian and Turkish families is caused by the same molecular defect in the albumin gene
    (Seoul National University, Institute for Cognitive Science, 2018) Caridi, Gianluca; Maout, Abdelbasset; Artan, Reha; Campagnoli, Monica; Lugani, Francesca; El Amine Abada, Mohamed; Sayar, Ersin; Galliano, Monica; Minchiotti, Lorenzo
    [No abstract available]
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    Hearing evaluation with ABR in pediatric patients with celiac disease
    (Aves, 2020) Yaprak, Neslihan; Sayar, Ersin; Derin, Alper Tunga; Bostancı, Aslı; Turhan, Murat; Yılmaz, Aygen
    Background/Aims: Celiac disease (CD) is an autoimmune and genetic disease that is triggered by gluten intolerance. We aimed to investigate whether Celiac disease have any effect on Auditory Brainstem Response (ABR) waves compare to a healthy control group, and present its association with sensorineural hearing loss (SNHL). Materials and Methods: Thirty-eight patients aged 2 to 16 years old were included in the study. The patients had confirmed diagnosis of Celiac disease through duodenal biopsies and transglutaminase Antibody (Ab) (+). The control group consisted of 18 children aged 3 to 17 years old who were all admitted to the pediatric gastroenterology department due to complaints of constipation and transglutaminase Ab (-). All children underwent Auditory-Brain-Stem-Evoked Responses (ABR). The data were gathered using click stimulus at 10/s frequency 90dB HL. Results: The results of ABR examination did not show any difference between the patient group and control group as regards the latency of the waves I, III, V. No difference was observed between the two groups in the interpeak latecies I-III, I-V and III-V. None of the patients was observed to have clinical hearing loss. Discussion: The exact pathogenesis of neurological damages observed in Celiac disease is still unknown. Humoral immune mechanisms are the most frequently attributed cause. Conclusion: Although no significant difference was found in hearing values between the study group and healthy control group, there is a need for further research on this subject.
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    Oxidant-Antioxidant Balance and Trace Elements in Children with Functional Dyspepsia
    (2021) Savaş, Hasan Basri; Sayar, Ersin
    Objective: Functional dyspepsia (FD) is the most common functional abdominal pain disorder among children and adolescents according to the Rome IV criteria. The aim of the study was to determine the possible effect of the equilibrium of oxidant and antioxidant and trace elements in pediatric FD. Material and Methods: The patient group consisted of 23 children who were diagnosed with FD according to the Rome IV Questionnaire on Pediatric Gastrointestinal Disorders. The control group consisted of 23 children aged 11-17 who did not meet the Rome IV criteria and had no chronic disease. Measurements of zinc, copper levels and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit. Routinely measured hemogram and vitamin B12 and vitamin D test results were obtained from the patient files retrospectively. Results: In comparison of the control group, the pediatric FD group had significantly higher levels of oxidized thiol, ischemia-modified albumin, neutrophil and neutrophil/lymphocyte, a significantly lower lymphocyte count and reduced thiol ratio, and significantly lower vitamin D, native thiol, and copper levels. Conclusion: FD is potentially related to inflammation, serum copper content, and oxidative stress. However, the relationship between FD and inflammation, copper levels, and oxidative stress has not been adequately investigated in children. As a conclusion of this clinical trial, thiol balance, ischemia modified albumin, neutrophil/lymphocyte ratio, vitamin D and copper content will likely be essential for diagnosis and follow-up in pediatric FD
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    Thiol disulfide balance oxidative stress and paraoxonase 1 activities in children and adolescents aged 6-16 Years with specific learning disorders
    (2021) Savaş, Hasan Basri; Sayar, Ersin; Kara Tayfun
    Introduction: Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters. Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods. Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion: The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.