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    Öğe
    Nasal CPAP and BiPAP as the Initial Respiratory Support in Preterm Infants: A Randomized Controlled Trial
    (Georg Thieme Verlag Kg, 2025) Arayici, Sema; Simsek, Gulsum Kadioglu; Say, Birgul; Oncel, Mehmet Yekta; Sari, Fatma Nur; Uras, Nurdan; Dizdar, Evrim
    Objective This study aimed to compare the nasal continuous positive airway pressure (nCPAP) and bi-level positive airway pressure (BiPAP) in preterm infants with respiratory distress syndrome (RDS). Method Preterm infants (<= 32 weeks of gestation) were randomly assigned, at birth, into two study groups: nCPAP or BiPAP. Primary outcomes (surfactant administration and failure of non-invasive respiratory support within the first 72 hours), and secondary outcomes (duration of ventilation support, pneumothorax, bronchopulmonary dysplasia, patent ductus arteriosus, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity, time to total enteral feeding, length of hospital stay, and mortality) were assessed. Results A total of 188 preterm infants with RDS were analysed. Mean gestational age was 28.8 +/- 1.8 weeks (nCPAP) versus 29 +/- 1.9 weeks (BiPAP). There were no statistically significant differences between groups in the failure of non-invasive respiratory support (25% vs. 33%, RR: 0.74, 95% CI: 0.47-1.17) or surfactant administration (35% vs. 38%, RR: 0.92, 95% CI: 0.49-1.71). No significant differences were observed in secondary outcomes between the two groups. Subgroup analysis of infants<30 weeks yielded similar results. Conclusion Although two-level CPAP theoretically offers benefits, BiPAP was not superior to nCPAP as initial support in preterm infants with RDS. This underscores the continued value of the simpler, well-established nCPAP and the need for multicentre trials involving preterm infants of varying gestational ages.
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    Öğe
    Yenidoğanda Nadir Bir Solunum Sıkıntısı Nedeni: Primer Siliyer Diskinezi
    (2024) Say, Birgul; Sağlam, Celal
    Primer siliyer diskinezi (PSD), solunum yolunu kaplayan silyaların yapısını ve işlevini etkileyen nadir bir kalıtsal hastalıktır. PSD’de yenidoğanlarda solunum sıkıntısı yaygındır. Açıklanamayan solunum sıkıntısı ve lober kollaps, situs inversus veya uzun süreli oksijen tedavisi gereksinimi olan term bebeklerde PSD için tanısal bir çalışma düşünülmelidir. Bu raporda, yenidoğan döneminde PSD tanısı konulan bir olgu sunulmaktadır.