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    Diagnosis of covid-19 in children and nursing approach: A systematic review
    (2021) Sarman, Abdullah; Tuncay, Suat; Sarman, Emine
    Aim: This study was carried out to summarize the systematic literature review on current information about Serious acute respiratory syndrome 2 (SARS-CoV-2 or Covid-19 in children and to determine nursing approach. Methods: Regarding the research, 156 publications were examined between 21 January and 15 November 2020. The review was conducted with the key words of “SARSCoV-2”, “coronavirus”, “Covid-19”, “child”, “nursing”, which are openly accessible on databases such as PubMed, Science Direct and the WHO. Results: Covid-19 infection may be asymptomatic or characterized by fever and fatigue in children; they can be potential carriers of the disease. Several upper respiratory symptoms have been seen, such as nasal congestion and a runny nose. In some patients, abdominal pain, nausea, vomiting and diarrhea occurs. Fever and cough were evident in pediatric patients. As the condition progresses, dyspnea, cyanosis and other signs may arise after typically one week of the disease, along with systemic toxic signs, including restlessness or malaise, decreased appetite, poor feeding and reduced activity. Children’s condition might progress quickly and turn to respiratory failure, which cannot be improved by conventional oxygen within 1-3 days. Metabolic acidosis, septic shock, irreversible bleeding and coagulation dysfunction can take place in such severe cases. However, Covid-19 may cause an inflammatory reaction in some children. Those starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with Covid-19 could have severe complications. Conclusion: This systematic review has shown that children generally develop mild Covid-19 disease and these infections are often acquired through community sources. Diagnosis of the disease is difficult in children and there is limited data on children with Covid-19. The disease mainly causes fever, respiratory symptoms and other flu-like manifestations in children. The signs and symptoms of the disease should be carefully monitored. Nurses should know the course and symptoms of the disease well in children and take precautions.
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    Irbesartan restored aquaporin-1 levels via inhibition of NF-kB expression in acute kidney injury model
    (Soc Espanola Nefrologia Dr Rafael Matesanz, 2024) Candan, Busra; Ilhan, Ilter; Sarman, Emine; Sevimli, Murat
    Introduction: Acute kidney injury (AKI) is a serious pathology that progress with dysfunction of regulating blood pressure and fluid balance, concentrating urine due to decrement of aquaporin-1 (AQP) levels during the inflammation process. Irbesartan (IRN), angiotensin receptor blocker, is widely used in the treatment of hypertension, which also has antiinflammatory, antioxidant and anti-apoptotic properties. The aim of this study is to investigate the protective effects of IRN in lipopolysaccharide (LPS)-induced kidney injury. Material and methods: Twenty-four rats divided into three groups as control, LPS and LPS + IRN group. After 6 h of LPS administration, rats were sacrificed. Blood samples and half of the kidney tissues were collected for biochemical analysis and remaining tissues were taken for histopathological and immunohistochemical analysis. Results: In the LPS group, glomerular congestion and shrinkage, degeneration of distal tubules, mononuclear cell infiltration, cellular debris and intense proteinous accumulation in the tubules, increased expressions of Cas-3, nuclear factor kappa beta-p65 (NF-kB p65), levels of creatinin, TOS, OSI and decreased levels of TAS, AQP-1 were found significantly. IRN treatment reversed all these parameters. IRN's restorated AQP-1 levels by its anti-inflammatory, antioxidant and anti-apoptotic effects due to inhibiting NF-kB expression. Conclusion: This study suggests that IRN can be used in conditions affecting the kidneys such as AKI. Further studies needed for detailed molecular investigation of IRN at different doses and durations. (c) 2023 Sociedad Espa nola de Nefrolog & imath;a. Published by Elsevier Espa na, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).