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    Efficacy and safety of omitting 5-fluorouracil bolus in combination chemotherapy regimens for gastrointestinal cancers: a systematic review and meta-analysis
    (Taylor & Francis Ltd, 2025) Ilhan, Yusuf; Balcik, Onur Yazdan; Sahin, Elif; Merc Cetinkaya, Aysegul; Almuradova, Elvina; Bardakci, Murat; Dinckal, Cigdem
    IntroductionThis meta-analysis aimed to evaluate the impact of omitting the 5-FU bolus in chemotherapy regimens for gastrointestinal cancers on treatment efficacy and toxicity.MethodsWe searched major databases and congress proceedings until 25 October 2024 to identify studies comparing 5-FU bolus and non-5-FU bolus regimens in patients with gastrointestinal cancers. The studies included those reporting on progression-free survival (PFS), overall survival (OS), and adverse events in metastatic gastrointestinal cancer patients.ResultsThe analysis included 7 studies with 12,698 patients. No significant differences in PFS (HR: 0.94, 95% CI: 0.83-1.07) or OS (HR: 0.96, 95% CI: 0.89-1.03) were found between the 5-FU bolus and non-bolus groups. However, significantly higher rates of grade 3-4 neutropenia (OR: 0.46, 95% CI: 0.37-0.57) and any grade thrombocytopenia (OR: 0.53, 95% CI: 0.35-0.80) were observed in the 5-FU bolus group. No significant differences were found for other toxicities like febrile neutropenia, diarrhea, or nausea.ConclusionsThis meta-analysis demonstrates that the omission of 5-FU bolus from the commonly used 5-FU-based chemotherapy regimens in gastrointestinal cancers, with the use of only 5-FU infusion, may reduce the risk of hematologic toxicities such as neutropenia and thrombocytopenia without affecting survival outcomes in metastatic gastrointestinal cancers.Protocol registrationwww.crd.york.ac.uk/prospero identifier is CRD42024602968.
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    Pet-Based Family Model as a Global New Family Form: A Qualitative Study
    (Springernature, 2025) Ozturk, Ali; Ceritli, Ismail; Sahin, Elif
    As a result of the transformative changes in the 21st century, various studies have highlighted a gap in the literature regarding the need for new definitions of the family, while also emphasizing that the position of domestic animals within the family has not been sufficiently examined in historical contexts. This paper addresses a new conceptualisation of the family unit, wherein domestic (or non-domestic) animals assume the role of a core member or the most significant member of the family. The theoretical framework of the article is based on the impact of the individualisation model developed by Beck and Beck-Gernsheim on relationships and ties. Phenomenological analysis based on qualitative methodology was used in the study and it was completed with face-to-face interviews with 17 people who were reached except for preliminary interviews by using the maximum diversity sampling technique and the data were analysed thematically. Despite various social, economic and physical challenges, the research results show that a close bond is established between pets and family members, with pets being seen as members of the family. The research also shows that pets have a positive effect on family relationships and are good for family members' physical and psychological well-being.