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    Can Serum Biomarker Values from Second-Trimester Aneuploidy Screening Predict the development of Retinopathy of Prematurity in Premature Infants?
    (2024) Sabancı, Şenol; Küçük, Mehmet Fatih; Savas, Hasan Basri; Süren, Elçin; Erol, Muhammet Kazim; Yavuz, And; Sipahioğlu, Haydar
    Objectives: This study aimed to evaluate serum biomarker values measured during second-trimester aneuploidy screening in terms of their predictive ability for the development of retinopathy of prematurity (ROP) in premature infants. Methods: This retrospective cohort study evaluated the data of 1985 idiopathic premature infants who underwent ROP screening from 2016 to 2022. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two subgroups based on the presence of proliferation. Comparisons were made concerning the serum multiple of the median values of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and alpha-fetoprotein (AFP) among aneuploidy screening biomarkers. Results: While 1628 premature infants were in the non-ROP group, 357 were in the ROP group. Of the infants with ROP, 72 were in the proliferative ROP group and 285 in the non-proliferative ROP group. There was no significant difference in the multiple of the median values of the evaluated serum biomarkers (uE3, hCG, and AFP) between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion: The multiple of the median values of second-trimester aneuploidy screening serum biomarkers were not able to predict the development of ROP in premature infants. This result may have been caused by the fact that the blood tests were taken only once and in the same weeks.
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    Is age-related macular degeneration a local manifestation of systemic disorder? Changes in nailfold capillaries at age-related macular degeneration
    (Springer London Ltd, 2020) Küçük, Mehmet Fatih; Ayan, Ayşe; Toslak, Devrim; Süren, Elçin; Yaprak, Lütfiye; Çetinkaya, Ersan; Çoban, Deniz Turgut
    Aims Determining whether nailfold capillary involvement is present in patients with Age-related macular degeneration (AMD) and whether there are different nailfold capillaroscopy findings between wet and dry types. Methods From January 2016 to December 2017, with an initial diagnosis of AMD, 53 consecutive adult patients (AMD group) and 91 age- and sex-matched healthy individuals were studied prospectively. There was no history of any other ocular disease and other disease affecting nailfold capillaries. All subjects underwent a complete ophthalmic examination. The classified and advanced stages of wet and dry types were not included. All nailfold capillaroscopy examinations were performed by the same rheumatologist. Results It was found that the frequency of major capillaroscopic findings such as capillary ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre capillary, and bushy capillaries increased in the AMD group according to the normal group, but no significant relationship was found for capillary aneurysm. In dry or wet type of AMD in terms of ectasia, micro-hemorrhage, tortuosity, neo-formation, bizarre structure, bushy structure, or aneurism of nailfold capillaries, no significant correlation was found. Conclusions Nailfold capillaroscopy can detect microvascular changes in the nailfold capillary, in early and late stages of AMD. There were morphological changes in the nailfold capillaries of AMD patients, suggesting that there are systemic superficial microvascular changes that may be due to the systemic nature of the disease.
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    The Outcomes of Limbal Conjunctival Autograft Transplantation in The Treatment of Primary and Recurrent Pterygiums
    (Bolu Abant İzzet Baysal Üniversitesi, 2020) Kalaycı, Mustafa; Çetinkaya, Ersan; Süren, Elçin; Küçük, Mehmet Fatih; Yiğit, Kenan; Coban, Deniz Turgut
    INTRODUCTION: To evaluate the results of limbal conjunctival autograft transplantation (LCAT) in patients with primary and recurrent pterygium. METHODS: Forty-two eyes of 38 patients were included in the study. 26 of them were primary, while 16 were recurrent pterygium. Limbal conjunctival autograft transplantation was performed after the pterygium excision to all eyes. Patients having a follow-up of at least 12 months were evaluated with respect to demographic data, pterygium grade, surgical complications, recurrence rate, refractive astigmatism and visual acuity. RESULTS: The mean age of the patients was 44 ± 8.5. Twenty-six (68.4%) patients were male and 12 (31.6%) were female. No recurrence were observed in primary pterygium group, whereas two recurrences were observed in recurrent pterygium group. The overall recurrence rate was 4.7%. Buttonhole complication occurred while forming the graft in three patients. Conjunctival inclusion cyst developed in 2 patients with recurrent pterygium. DISCUSSION AND CONCLUSION: Limbal conjunctival autograft transplantation seems to be an effective and safe surgical option in both primary and recurrent pterygiums.