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    Öğe
    Acute respiratory injury model in rats
    (İstanbul Veteriner Hekimler Odası, 2023) Özsoy, Şule; Yılmaz, Banu Karakuş; Oran, Duygu Sultan
    Aim: Acute respiratory distress syndrome (ARDS) can develop as a result of many diseases and It causes a high rate of death. Research on treatment is still continuing. Thats why, we aimed to create an acute respiratory tract injury model with low mortality risk in rats. Material and method: Three 160 gr Winstar Hannover male rats were used in the prestudy. One of the rats was left as a control and was sacrificed. The other two were intubated and intratracheal lipopolysaccharide (LPS) administered. One of the rats which LPS was applied was sacrificed 6 hours and the other 12 hours later, and the lungs, brain, heart, kidney, liver and intestines were examined histopathologically. Results: In both of the rats treated with LPS, inflammation was observed in the peribronchial areas, which decreased more intensely towards the periphery of the lung. However, it was noted that inflammation was more intense in the lung of the rat, which was sacrificed after 12 hours. No pathological findings were detected in other organs. Conclusion: In the LPS-induced acute respiratory tract injury model, the lung periphery remains intact, allows a controlled, local inflammation, and doesn’t affect other organs, significantly reducing the mortality risk of the subjects. This model’s feature is important for the sustainability of research.
  • [ X ]
    Öğe
    Aircool
    (İstanbul Veteriner Hekimler Odası, 2023) Yılmaz, Banu Karakuş; Oran, Duygu Sultan; Özsoy, Şule
    Introduction:World Health Organization(WHO) defines sudden deathes as "deaths happening within 24 hours of the begining of symptoms". Sudden cardiac deaths account for 15-20% of all deaths. The first aim after cardiac arrest is to provide spontaneous circulation, and then the most important thing is to prevent the progress of neurological damage. Aim:Provide the patient with chilled oxygen therapy and to establish a system that will enable the therapeutic hypothermia application to be initiated as early as possible. For this purpose, we have produced a medical device to be used in the laboratory of experimental animals in order to study animal models before human models. While this device is avaible prototypical for human studies, it is sufficient to induce hypothermia for animal experiments specifically.Device:It has the feature that cooling oxygen to (–4) degrees. In addition,the device is avaible to the appropriate pressure and volume of oxygen to the experimental animal. In the creation process of the device, its compliance with medical standards was taken into account. Although the device was developed to develop a new method in the treatment of therapeutic hypothermia, it can also be used in studies planned to with cold air or other gases in animal experiments. The most important disadvantage of the current prototype device is that it is not compatible with mechanical ventilators, and we continue to work on this subject.Innovative aspect of the device:There is no treatment way in which only oxygen is used by cooling in order to create hypothermia for therapeutic purposes in the world. The currently used technique cool the patient by placing a cannula in the large vein and cooling the blood passing around the cannula, or methods that allow the patient to cool down by injecting a large amount of cold serum into the vein. We have determined our method is a faster, more effective and reliable method compared to the currently used methods.Result:The device can be used in animal experiment studies where the therapeutic hypothermia method will be used in experimental animal laboratories, for educational purposes in veterinary faculties, and in pre-production studies in pharmaceutical companies.