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    Öğe
    Assessment of Preanalytical Errors by Six Sigma Method and the Pareto Principle Analysis
    (2023) Oktay, Saniye Başak; Hanikoglu, Ferhat
    Aim: In this study, we aimed to evaluate the preanalytical errors over a five year period using the Six Sigma methodology and Pareto Principle in the clinical biochemistry laboratory. Methods: Five-year sample rejection data between January 2015 and December 2019 in the clinical biochemistry laboratory were analyzed and classified according to the reasons for rejection. Six Sigma levels for the total and each preanalytical error were calculated with Westgard online formula. Preanalytical errors were evaluated according to their frequencies ranks and percentages with Pareto's principle. Results: The overall rate of five-year total critical preanalytical errors was 1.91% and the sigma level was 3.6. According to Pareto's chart, the three most common errors among the five-year preanalytical rejections were clotted sample (42.49%, sigma value:4), insufficient sample (23.53%, sigma value:4.2), and wrong container (8.01%, sigma value:4.5). Conclusion: Six Sigma is a quality management methodology used to evaluate laboratory performance processes according to universal quality criteria. Calculated sigma values of preanalytical errors in our laboratory were within the acceptable range. However, planned regulatory activities for frequently observed preanalytical errors should be a laboratory management strategy to reduce these error rates and improve our laboratory performance.
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    Öğe
    Does previous tuberculosis increase the risk of functional gastrointestinal disorders in children?
    (2024) Uygun, Hatice; Yavuz, Sibel; Erdem, Nurettin; Oktay, Saniye Başak; Ozen, Seval; Turgut, Mehmet
    Objective: Functional gastrointestinal disorders (FGIDs) encompass a range of chronic conditions of unknown etiology, including functional dyspepsia, irritable bowel syndrome, functional abdominal pain, and functional constipation. The exact pathogenic mechanisms behind tuberculosis (TB) are unclear. This study aimed to investigate whether children with previous TB are at an increased risk of developing FGIDs after completion of TB treatment. Materials and Methods: A total of 35 patients diagnosed with TB (age range, 24 to 216 months) and 49 age- and sex-matched healthy controls were included in this retrospective study. Patients were evaluated for the presence of FGID symptoms after at least 6 months had passed after cessation of TB treatment, while the control group was assessed at the time of their first examination according to the Rome IV criteria. Results: The overall prevalence of FGIDs was 42.9% (n=15) in the patient group versus 12.2% (n=6) in the control group. A significant difference was found between the groups in terms of the frequency of FGIDs and the diagnosis of functional abdominal pain (p = 0.001 and p < 0.001, respectively). Conclusions: This study demonstrated a higher prevalence of FGIDs in children with a history of TB compared to healthy controls, supporting the hypothesis that FGIDs are more common in children with previous TB. Children with previous TB may be at an increased risk for FGIDs, possibly due to chronic inflammation and immune system alterations associated with TB, highlighting the need for ongoing assessment of GI health in this population.