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    Role of VEGF I/D variant in suspectibility to odontogenic cyst formation
    (Taylor & Francis Inc, 2023) Yildiz, Serkan; Nursal, Ayse Feyda; Yigit, Serbulent; Tumer, Mehmet Kemal
    Odontogenic cysts, are located in the jawbones, filled with fluid surrounded by epithelial lining and fibrous connective tissue. Vascular endothelial growth factor (VEGF) can induce physiological and pathological angiogenesis and is an endothelial cell-specific mitogen. The aim of the present study was to investigate whether any possible association between the VEGF insertion/deletion (I/D) variant and odontogenic cyst in Turkish population. Clinical information and venous blood samples were collected from 62 odontogenic cyst patients and 98 healthy controls. DNA was isolated from peripheral blood leukocytes. Genotyping of the VEGF I/D variant was done by the polymerase chain reaction (PCR) method. There was a statistically differece in terms of VEGF I/D allele frequencies between patients and controls. VEGF I/D variant I allele frequency was more prevalant in patients compared to controls (p = 0.006411, OR: 2.08, 95%Cl: 1.322-3.272). A statistically significant association was observed when the patients were compared with the controls according to D/D + I/D versus I/I genotype (p = 0.0508, OR: 1.925, 95%Cl: 0.872-4.246). The genotype distribution of VEGF I/D was not statistically different between patients and controls (p > 0.05). For the first time, our results provided evidence supporting the odontogenic cyst formation associated with the I/D variant at the promoter region of the VEGF gene in a group of Turkish population. Although it was seen in our study that the I/D variant in the promoter region of the VEGF gene supports odontogenic cyst formation, large-scale studies are needed to elucidate the effect of this variant on odontogenic cysts.
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    Öğe
    The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
    (2024) Yildiz, Serkan; Yigit, Serbulent; Nursal, Ayse Feyda; Karakus, Nevin; Tumer, Mehmet Kemal
    Background: Temporomandibular joint disorder (TMD), a set of conditions that affect the temporomandibular joint and related structures, is frequently linked to bruxism. The vitamin D receptor (VDR) affects calcium absorption, bone remodeling, and mineralization rate. The goal of this study was to evaluate the role of the VDR Bsm1 (rs1544410) variant in the susceptibility to bruxism in TMD. Method: A total of 321 people [221 TMD patients (135 with bruxism and 86 without bruxism) and 100 healthy controls] were included in the study. The VDR Bsm variant was genotyped using the PCR-RFLP method. Results: We found no significant difference between the all-TMD patient group and the control group regarding the VDR Bsm1 genotype and allele distribution (p>0.05). There was no deviation from HWE for the VDR variant in groups. There was no relationship between pain characteristics and VDR Bsml genotype distribution in patients with bruxism. Conclusions: Our results support the conclusion that the VDR Bsm1 variant is not a risk factor for the development of bruxism in TMD. The effect of the VDR Bsml variant on the risk of bruxism in TMD should be investigated in studies involving larger populations and other ethnicities.