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Caffeic Acid Based Polyurethane Membrane Modified Screen-Printed Electrodes and Their Application for the Simultaneous Determination of Melatonin and Serotonin
(Taylor & Francis Inc, 2025) Erel, Ensar; Tunc, Merve Goksin Karaaslan; Koytepe, Suleyman; Ates, Burhan; Yilmaz, Ismet
Caffeic acid (CA) based polyurethane (PU) films were synthesized and characterized for the simultaneous determination of melatonin (MT) and serotonin (5-HT). The CA based PUs were synthesized using a polyol mixture of 4,4'-diisocyanodiphenylmethane (MPI), polyethylene glycol-200 (PEG), and CA. The PEG-CA monomer units in the polyol were varied in molar ratios of 99:1, 97:3, 95:5, and 90:10. The synthesized PUs were characterized by FTIR spectroscopy and thermal analysis. These CA based PU films were coated onto screen-printed carbon electrodes (SPCEs) with varying thicknesses and used for the simultaneous determination of MT and 5-HT. Electrochemical responses of MT and 5-HT were evaluated using differential pulse voltammetry. The limit of detection and correlation coefficient for MT were 280 mu M and 0.9797, respectively, while for 5-HT, the detection was 150 mu M with a correlation coefficient of 0.9690. The precision, expressed as the relative standard deviation was 2.633% for MT and 4.668% for 5-HT. These findings suggest that CA based PU-modified electrodes hold potential in medical and biomedical applications.