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    Association of ANKK1 and DRD2 gene polymorphisms with exercise addiction among elite athletes
    (Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Yeliz A.; Kasakolu, Anil; Bulgay, Celal; Biyikli, Turker; Kazan, Hasan H.; Koncagul, Seyrani; Bayraktar, Isik
    Exercise addiction is a behavior that may dysregulate athletic performance, and social and professional interactions of athletes. Whereas environmental factors including training routines and personal traits could contribute to exercise addiction, recent studies have emphasized the importance of genetic predisposition, leading to development of a subfield known as sports psychogenetics. In sports psychogenetics, ankyrin repeat and kinase domain containing 1 (ANKK1) and dopamine receptor D2 (DRD2) genes, located on chromosome 11 in a close proximity, have attracted research interest due to their involvement in dopaminergic signaling playing a crucial role in reward processing, motivation, cognition and behavior. Therefore, the present study aimed to investigate potential associations between 14 polymorphisms in ANKK1/DRD2 and exercise addiction among elite badminton players (n = 39) and elite wrestlers (n = 68). Exercise addiction was assessed using a psychometric screening instrument and allele frequencies of the selected polymorphisms were analyzed through genotyping with a single nucleotide polymorphism (SNP) microarray. Results indicated that two SNPs, rs7118900 and rs4436578, were significantly and independently associated with exercise addiction. Rs7118900 has previously been associated with an increased risk of drug addiction, neuroticism, and depressed effect whereas rs4436578 has been associated with neuroticism. In addition to those SNPS, rs2283265 and rs1125394 SNPs were also linked to exercise addiction in a branch-independent manner. Therefore, it is proposed that these SNPs could serve as genetic markers for identifying individuals at high risk of exercise addiction among athletes. However, further research is needed to understand the involvement of these SNPs in exercise addiction more comprehensively.
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    BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits
    (Springer, 2025) Bulgay, Celal; Zorba, Erdal; Kazan, Hasan H.; Bayraktar, Isik; Uca, Merve; Ergun, Mehmet A.; John, George
    PurposeRecent research suggests a link between brain-derived neurotrophic factor (BDNF) and the mTOR signaling pathway, a key regulator of protein synthesis and muscle growth. However, it remains unclear whether BDNF influences muscle growth and power performance. Our study aimed to investigate the relationship between the expression of BDNF and MTOR genes in human skeletal muscle and examine the association between genetically predicted higher expression of the BDNF gene and muscle fiber size, lean mass, power performance, and power athlete status. MethodsThe study involved 456,382 subjects, including 285 athletes, 112 physically active individuals with muscle fiber composition data, 291 sedentary individuals with gene expression data, 5451 controls, and 450,243 UK Biobank participants. The muscle fiber composition was evaluated using immunohistochemistry, while gene expression analysis was performed using RNA sequencing. BDNF genotyping was carried out using real-time PCR or microarrays. ResultsWe found that BDNF gene expression was positively associated with MTOR gene expression in the vastus lateralis (p < 0.0001). Furthermore, genetically predicted higher BDNF expression (i.e., carriage of the C allele of the rs6265 (Val66Met) BDNF polymorphism) was positively associated with the cross-sectional area of fast-twitch muscle fibers in athletes (p = 0.0069), appendicular lean mass (p = 2.6 x 10(-)(7)), personal best scores of power athletes (p = 0.029), and power athlete status (p = 0.0056). ConclusionOur study demonstrates a positive correlation between BDNF and MTOR gene expression in human skeletal muscle, with genetically predicted higher BDNF expression associated with greater muscle fiber size, lean mass, enhanced power performance, and power athlete status.