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  • Küçük Resim
    Öğe
    Characteristics and predictors of family accommodation in Turkish individuals with obsessive-compulsive disorder
    (2023) Kuru, Tacettin; Çelik Erden, Selime; Doğan, Veysel; Karakuş, Kadir
    Background/aim: Family accommodation (FA) is associated with disease severity and response to treatment rates in patients with obsessive-compulsive disorder (OCD) and is therefore particularly important in this patient group. This study investigated the structure of FA and associated factors in a Turkish society sample. Materials and methods: The study was carried out with 92 patients diagnosed with OCD for at least 1 year, who applied to Alanya ALKU Training and Research Hospital psychiatry outpatient clinic between February 2021 and March 2022. Sociodemographic data form, Family Accommodation Scale-Patient Form (FAS-PF), Dimensional Obsessive-Compulsive Scale (DOCS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Acceptance and Action Questionnaire (AAQ-II) were applied to all of the cases. Relatives filled out the Sociodemographic Data. Results: The mean age of the patients was 32.11 ± 11.56 years. Sixty-nine (75%) of the patients were women. Fifty (54.3%) patients were married. All participants reported FA behavior at least once in the previous week. FA exhibited no significant variation by sex (p = 0.679) or marital status (p = 0.256). Significant positive correlation was determined between DOCS-T (r = 0.370, p < 0.001), AAQ-II (r = 0.261, p = 0.013), BDI (r = 0.235, p = 0.024) and BAI (r = 0.342, p = 0.001) scores and the FAS-PF. In the regression analysis, only OCD disease severity predicted FA [(? = 0.295, p = 0.036, 95% confidence interval (95% CI) = 0.02 to 0.55)]. Higher FA scores were obtained in this study (23.93 ± 15.28) compared to previous research in Western societies (14.3 ± 15.2). Conclusion: Clinicians should consider FA in the examination of OCD patients. High FA values for both frequency and severity suggest that interventions directed toward FA may be associated with more positive outcomes in outpatient Turkish patients with OCD. © TÜBİTAK.
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    Öğe
    Correlation Between Suicidal Behavior and Depression, Anxiety, Stress Levels and Sociodemographic Characteristics in University Students
    (2025) Karakuş, Kadir; Uygur, Abdullah Burak; Celik, Selime; Al, Ahmet; Gölgeli, Umut; Öz, Ali Emre
    Aim: Studies conducted on university students have reported high levels of depression, anxiety and stress as well as suicidal thoughts and suicide attempts. This study aimed to determine the correlation between suicidal behavior and depression, anxiety, stress levels and sociodemographic characteristics in university students. Method: Participants who agreed to participate in this online study were asked to fill in the sociodemographic data form and the Depression Anxiety Stress Scale-21 (DASS-21). Among the 530 participants, 517 (97.6%), having read information about the study, agreed to participate, while 13 (2.4%) declined. Results: In this study, 36% of the participating university students had a history of major suicidal ideation, 6.4% currently experienced major suicidal ideation and 14.7% had attempted suicide. Depression, anxiety and stress scores were found to be higher in university students who had attempted suicide or currently experienced major suicidal ideation compared to those who had/did not (p?0.001). With regard to sociodemographic factors; perceived and actual academic performance levels, socioeconomic status, current dieting status, sleep problems, smoking, daily time spent online, chronic diseases, and past or current psychiatric treatment were found to be common risk factors for both current major suicidal ideation and suicide attempt status (p?0.05). Conclusion: Having found high levels of depression, anxiety and stress among university students in this study, we consider that it is necessary to investigate the factors associated with suicidal ideation and suicide attempts, and that comprehensive psychosocial support units and programs should be developed to protect students' mental health and reduce risk of suicide.
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    Öğe
    Duloksetinin Rat Beyin Dokularındaki Oksidan-Antioksidan Sistem Üzerine Etkisi
    (İbrahim İKİZCELİ, 2024) Karakuş, Kadir; Demirci, Kadir; Uz, Efkan; Yiğit, Ayşe; Özcankaya, Ramazan
    Amaç: Oksidatif stres (OS) ve depresyon arasındaki ilişki gösterildikten sonra antidepresanların OS üzerine etkisi önemli hale gelmiştir. Bu çalışmanın amacı duloksetinin rat beyin dokularındaki katalaz (CAT), süperoksit dismutaz (SOD), adenozin deaminaz (ADA), ksantin oksidaz (XO) ve glutatyon peroksidaz (GSH-Px) enzim aktiviteleri ile nitrik oksit (NO) ve malondialdehid (MDA) düzeylerine etkilerini araştırmaktır. Gereç ve Yöntem: Çalışmaya birinci grup kontrol grubu (n=10) ve ikinci grup duloksetin grubu (n=10) olmak üzere toplam yirmi tane Sprague-Dawley cinsi erkek rat alındı. Duloksetin grubuna günde bir defa 10 mg/kg dozunda intragastrik yoldan iki hafta süreyle duloksetin verildi. Kontrol grubuna da günde bir defa iki hafta süreyle intragastrik olarak su verildi. On beşinci günde tüm ratlar sakrifiye edilerek beyin dokuları çıkarıldı ve incelemeler yapıldı. Bulgular: Çalışmamızda duloksetinin rat beyin dokularında kontrol grubuna kıyasla SOD (P=0,026) enzim aktivitesini anlamlı düzeyde artırdığını ve XO (P=0,034), ADA (P=0,041) ve CAT (P=0,006) enzim aktivitelerini anlamlı düzeyde azalttığını saptadık. Ayrıca GSH-Px enzim aktivitesini anlamlı olmayan düzeyde artma ve MDA ile NO düzeylerinde ise anlamlı olmayan düzeyde azalma saptadık. Sonuç: Çalışmamızda antioksidan bir enzim olan SOD enzim aktivitesinin anlamlı düzeyde artması, organizmada reaktif oksijen ürünleri oluşumuna neden olabilen XO ve ADA enzim aktivitelerinin anlamlı düzeyde azalması ve LP göstergesi olan MDA’nın artmayıp, anlamlı düzeyde olmasa da azalması duloksetinin antioksidan durumu olumlu yönde değiştirebileceğini düşündürmektedir.
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    Öğe
    Evaluation of Coronavirus Anxiety Levels and Coping Strategies of Major Depressive Disorder, Generalized Anxiety Disorder, and Panic Disorder Patients During the Covid-19 Pandemic
    (2023) Celik, Selime; Uygur, Abdullah Burak; Karakuş, Kadir
    Objectives: This study aims to compare patients with major depressive disorder (MDD), generalized anxiety disorder (GAD), and panic disorder (PD), whom we have frequently seen in our hospital practice during the pandemic, with healthy controls (HC) in terms of coronavirus anxiety levels and coping strategies. Methods: In this study, the Sociodemographic Data Form, Coronavirus Anxiety Scale (CAS), Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and Coping Orientation to Problems Experienced (COPE) scale were applied to the participants. 30 MDD patients, 32 GAD patients, 31 PD patients and 38 HCs, totaling 131 participants, constituted the sample of the study. Results: Evaluation of the CAS scores of the participants revealed that HC scored 3.306 (p=0.002) points lower than GAD patients and 3.014 (p=0.005) points lower than PD patients, while HC and major depression patients were not statistically different in terms of CAS scores (p=0.880). In the comparison of coping strategies, HC scored 3.151 (p<0.001) points higher than MDD patients and 2.059 (p=0.004) points higher than GAD patients in terms of“active coping.”In terms of“planning,”HC scored 2.726 (p<0.001) points higher than MDD patients, 2.589 (p=0.001) points higher than GAD patients, and 2.171 (p=0.006) points higher than PD patients. Conclusion: This study found higher coronavirus anxiety levels in GAD and PD patients but no difference in MDD patients com- pared to HC during the COVID-19 pandemic, which may indicate that MDD patients can COPE better with coronavirus anxiety. Determining the coping strategies that individuals use to COPE with coronavirus anxiety during the COVID-19 pandemic may help mental health professionals to control disease-related stressors and contribute to the treatment process.
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    Öğe
    The Relationship Between Sociodemographic Factors, Severity of Depression and Anxiety, and Internet Addiction and Severity Among University Students in Alanya
    (2022) Uygur, Abdullah Burak; Celik, Selime; Güleken, Mehmet Diyaddin; Karakuş, Kadir; İdil, Ezgi
    Objective: This study was conducted to reveal the relationship between sociodemographic factors, severity of depression and anxiety, and internet addiction and severity among university students in Alanya. Methods: The sample consists of 537 students from different faculties who voluntarily accepted to participate in the research. The Sociodemographic Data Form, Beck Depression Inventory, Beck Anxiety Inventory, and Young Internet Addiction Scale were applied to the students. Results: Of the students, 74.5% (N=400) were defined as normal users, 25.3% (N=136) as mild–moderate internet addicts, and 0.2% (N=1) as severe internet addicts. Gender (P=.029), the purpose of internet usage being gaming (P=.012), information (P=.05), or pornography (P=.001), monthly income (P=.001), time spent on the internet (P=.001), tobacco use (P=.001), alcohol use (P=.001), number of siblings (P=.014), and history of psychiatric treatment (P=.049) were found to be sociodemographic factors associated with internet addiction. In addition, it was observed that students with internet addiction had higher depression (P=.001) and anxiety (P=.004) scores. Conclusion: The findings in the present study indicated that mild–moderate internet addiction is a relatively common problem among university students and carries a potential risk of developing into severe internet addiction. Simultaneous evaluation of university students for internet addiction when they attend psychiatric outpatient clinics for complaints of depression, anxiety, tobacco and alcohol addiction will make a significant contribution to the fight against internet addiction.
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    Öğe
    The Relationship Between Sociodemographic Factors, Severity of Depression and Anxiety, and Internet Addiction and Severity Among University Students in Alanya
    (2022) Uygur, Abdullah Burak; Çelİk, Selime; Güleken, Mehmet Diyaddin; Karakuş, Kadir; Idil, Ezgi
    Objective: This study was conducted to reveal the relationship between sociodemographic factors, severity of depression and anxiety, and internet addiction and severity among university students in Alanya. Methods: The sample consists of 537 students from different faculties who voluntarily accepted to participate in the research. The Sociodemographic Data Form, Beck Depression Inventory, Beck Anxiety Inventory, and Young Internet Addiction Scale were applied to the students. Results: Of the students, 74.5% (N = 400) were defined as normal users, 25.3% (N = 136) as mild–moderate internet addicts, and 0.2% (N = 1) as severe internet addicts. Gender (P = .029), the purpose of internet usage being gaming (P = .012), information (P = .05), or pornography (P = .001), monthly income (P = .001), time spent on the internet (P = .001), tobacco use (P = .001), alcohol use (P = .001), number of siblings (P = .014), and history of psychiatric treatment (P = .049) were found to be sociodemographic factors associated with internet addiction. In addition, it was observed that students with internet addiction had higher depression (P = .001) and anxiety (P = .004) scores. Conclusion: The findings in the present study indicated that mild–moderate internet addiction is a relatively common problem among university students and carries a potential risk of developing into severe internet addiction. Simultaneous evaluation of university students for internet addiction when they attend psychiatric outpatient clinics for complaints of depression, anxiety, tobacco and alcohol addiction will make a significant contribution to the fight against internet addiction. © 2022, Istanbul Universitesi. All rights reserved.