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    Red cell distribution width and subclinical left ventricular dysfunction in patients with ankylosing spondylitis
    (Alanya Alaaddin Keykubat Üniversitesi, 2018) Kocabaş, Hilal; Küçük, Murathan; Öncel, Can Ramazan; Yıldırım, Aytul Belgi; Kaçar, Cahit
    Aim: The aim of this study is to investigate the relationship between left ventricular function and red cell distribution width (RDW) measured by myocardial performance index in patients with Ankylosing Spondylitis (AS). Patients and Methods: The study included 35 patients with AS and 38 controls. Control group was consisted of age and gender matched individuals without any cardiologic complaint and systemic disease. Laboratory parameters including RDW tests and transthoracic echocardiographic evaluation were conducted consecutively on the entire cohort of ankylosing spondylitis patients and healthy individuals. Results: In our study, no statistically significant difference was found between two groups, in terms of general properties such as age, gender, Body Mass Index (BMI), body surface area, systolic and diastolic blood pressure, smoking, serum lipid levels and blood glucose levels. ESR and CRP levels of AS group were found to be significantly higher compared to that of control group. EF and FS, which are among the parameters of systolic function, were normal in all individuals of both groups and there was no significant difference between two groups. However, myocardial performance index (MPI ) was higher in patients with AS than in controls. In addition, we showed a significant positive correlation between RDW and MPI (r: 0.372 , p: 0.001). Conclusion: Myocardial performance index may be useful for the early diagnosis of potential heart failure, by providing an earlier diagnosis of left ventricular dysfunction in patients with ankylosing spondylitis. Also , red cell distribution width was significantly correlated with myocardial performance index in these patients.
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    Öğe
    The cardioprotective role of trimetazidine on cisplatin-induced cardiotoxicity
    (2020) Küçük, Murathan; Öncel, Can Ramazan
    [No abstract available]
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    Öğe
    The role of atrial myocardial deformation parameters in determining cardioversion success in atrial fibrillation patients
    (Gazi Univ, Fac Med, 2019) Öncel, Can Ramazan; Küçük, Murathan; Yıldırım, Aytül Belgi
    Aim: To investigate the role of left atrial myocardial deformation parameters measured by speckle tracking method in predicting cardioversion success in addition to conventional echocardiographic measurements in cardioversion (CV) planned patients with persistent atrial fibrillation (AF). Material and Methods: 60 patients scheduled for cardioversion were evaluated and 40 patients with atrial fibrillation were included in the study. Patients with sinus rhythm continuing after 24 hour monitoring were classified as group 1, and patients with AF were classified as group 2. Group 1 patients are divided into 2 groups according to 1st month ECG, as sinus rhythm maintained group and AF detected group. Results: The global left atrial strain S (LA S-S) and the global left atrial strain rate S (LA SR-S) measured before and after cardioversion were found to be significantly lower in the group with failed cardioversion (group 2) than those with successful group (group 1). The predictive value of LAVI value in cardioversion success was found to be 39 mL/m(2). At first month; LA SR-S measured before and after cardioversion in the maintained sinus rhythm group was significantly higher than the atrial fibrillation recurrence group. Also; the LA S-S, measured after cardioversion, was found to be significantly higher in the maintained sinus rhythm group. Conclusion: We showed that atrial myocardial deformation parameters could play role in determining CV success in patients with persistant atrial fibrillation. In addition; we determined that the LA SR-S value was as sensitive and specific parameter as LAVI in predicting cardioversion success.