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  • Küçük Resim
    Öğe
    A collision tumor with squamous cell carcinoma of skin overlying breast and invasive breast carcinoma
    (2021) Günizi, Özlem Ceren; Çalış, Hasan
    Invasive breast cancer is the most common carcinoma in women. Invasive ductal carcinoma, not otherwise specified (NOS), is the largest group of invasive breast cancers. The second most common cancer of skin is squamous cell carcinoma (SCC). Collision tumor is a very rare and unusual tumor. It is defined as the concrescence of two distinct primary neoplasms at one site. Herein, we report a 56-year-female patient who had a collision tumor in the right breast, composed of moderately differentiated squamous cell carcinoma (SCC) and invasive breast carcinoma NOS. In the literature, collision tumors in the breast are very rare and reported in various combinations, but there is only one reported case with SCC and invasive breast cancer, the same as in our case.
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    Öğe
    Endometrium karsinomu tedavisi sonrası edinilmiş vulvar Lenfanjioma sirkumskriptum : Olgu Sunumu
    (Alanya Alaaddin Keykubat Üniversitesi, 2018) Erdem, Dilek; Günizi, Özlem Ceren; Çelik, Yiğit Nilüfer
    Lenfanjiomalar, cilt ve ciltaltı dokuyu etkileyen lenfatik sistemin nadir görülen hamartomatöz malformasyonlarıdır. En sık görülen tip Lenfanjiyoma sirkumskriptumdur. Vulvar lenfanjiyoma circumscriptum (LC), yaygın görülen semptomları cinsel işlev bozukluğu ve enfeksiyon ile ağrılı, siğil bir lezyon olarak ortaya çıkabilen nadir bir durumdur. Konjenital formu çocuklarda görülürken, edinilmiş formu enfeksiyon, kanser,Crohn hastalığı, geçirilmiş pelvik cerrahiye bağlı olarak erişkinlerde oluşabilir. Bu yazıda, endometrium kanseri nedeniyle cerrahi tedavi sonrası bir yıldır vulvar lezyon ve kaşıntı şikayeti olan 73 yaşında kadın hastada edinilmiş tipte LS olgusunu sunduk. LS’yi genital siğil gibi diğer durumlardan ayırt etmek, hastalığın gidişatını değerlendirmek ve altta yatan hastalığın teşhis ve tedavisini uygulamak açısından önemlidir. Bu nedenle, bu nadir benign durumun klinik görünümünün yanında farklı histolojik görünümünü de tanımak önemlidir.
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    Öğe
    Investigation of Inflammation and Autophagy due to Biglycanmediated TLR2/4 Signaling in Oral Lichen Planus Tissues
    (2024) Günizi, Özlem Ceren; Günizi, Hüseyin; Ecıroglu, Hamıyet; Yıldız, Fatma
    Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis. We aimed to investigate the role of Biglycan (BGN) in Toll-like receptors (TLR)2/4- CD14 and TLR4-CD44 mediated signaling mechanisms in the pathogenesis of OLP. Methods: Twenty-one patients with a previous diagnosis of OLP and 21 patients with normal oral mucosa were included. RNA was isolated from biopsy samples of patients, and the gene expression of BGN, TLR2, TLR4, CD14, and CD44 was analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry. Results: According to our findings, the fold change rates of BGN, TLR2, TLR4, and CD14 mRNA levels in tissues obtained from patients with OLP were higher compared with the control group. TLR2, TLR4, and CD14 fold change rates were statistically significant (p<0.05). CD44 co-receptor mRNA levels were higher in the control group (p<0.05). Similar results were obtained by immunohistochemical analysis. Conclusion: BGN expression has a pro-inflammatory effect in various disease models. The BGN levels in the tissues of patients with OLP were higher than those of the control group, but the difference was not statistically significant. However, TLR2/4-CD14 and CD44 levels were upregulated, as well as CD44 levels were downregulated. We suggest that inflammation signaling is activated and autophagy is inhibited in OLP. BGN-dependent inflammation and autophagy signaling in OLP are evaluated for the first time.
  • Küçük Resim
    Öğe
    The effects of metamizole on hematopoietic progenitor cells: Suppression of hematopoiesis stimulation in vitro
    (2023) Maytalman, Erkan; Samur, Dilara Nemutlu; Günizi, Özlem Ceren; Kozanoğlu, lknur
    BACKGRAUND: There is evidence that the adverse effects of metamizole occur due to the effect of the drug on the hematopoietic stem/progenitor cells, and therefore, the disruption of hematopoiesis. Therefore, our study aimed to evaluate the effects of metamizole on hematopoietic stem/progenitor cells using cell culture techniques. MATERIAL AND METHODS: In our study, samples were taken from stem cell products of healthy allogeneic stem cell transplant donors. The colony-forming unit (CFU) assay was used for the cells obtained from these samples. In addition, the drug effects on cell proliferation were evaluated with the MTT. Furthermore, the cell colonies were labelled with immunofl uorescent antibodies and the effects of metamizole on cell types formed in culture were evaluated. RESULTS: We determined that metamizole negatively affects the proliferation of cells, especially starting from 10 ?M. As a result of the evaluation of colonization, we saw that the number of colonies decreased with increasing concentrations. Granulocyte-macrophage colonies were more affected at increasing concentrations than other colonies. As a result of the evaluations of our in vitro study, it was also shown as an important fi nding that the individual effects of the drug were highly variable. CONCLUSION: CFU method can be used as a suitable method to investigate the effects of drugs and toxic substances on hematopoiesis. We also think it may be suitable for pre-analysing hematopoietic side effects in new drug research. In addition, using stem cell samples in studies may contribute more easily to the in vitro simulation of hematopoietic differentiations (Fig. 7, Ref. 29)
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    Öğe
    Tongue solitary angiokeratoma
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Günizi, Hüseyin; Günizi, Özlem Ceren
    Angiokeratomais a capillary vascular malformation, characterized clinically by solitary ofmultiple papules or plaques. From a clinical point of view, it can show eithera generalized and diffuse form of presentation, or all localized one.Clinically, five varieties are generally recognized: 1. solitary papularangiokeratomas, 2.scrotal or vulvaranjiokeratomas, 3.multiple papular and plaquelike angiokeratoma circumscriptum, 4.bilaterallesions on the dorsum of toes and fingers,5.generalized systemic type angiokeratoma corporis diffusum. Isolated mucosalangiokeratoma of the tongue is extremely rare. We report an unusual case ofsolitary angiokeratoma on the tongue.
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    Öğe
    Tonsillektomi materyallerinde aktinomiçes
    (Alanya Alaaddin Keykubat Üniversitesi, 2020) Günizi, Özlem Ceren; Günizi, Hüseyin
    Amaç: Tonsillektomi çocuk yaş grubunda en sık yapılan ameliyatlardan birisidir. Actinomiçes türleri Gram-pozitif, spor oluşturmayan fakültatif anaerobik bakterilerdir. Aktinomikoz, subakuttan kronik enfeksiyona kadar apse oluşumu ile karakterize bir hastalıktır.Gereç ve Yöntemler: Ocak 2016 - Ocak 2019 tarihleri arasında Alanya Alaaddin Keykubat Üniversitesi Eğitim ve Araştırma Hastanesinde tonsillektomi uygulanan 185 hastanın tonsillektomi materyalleri ile çalıştık.Bulgular: Tonsillektomi yapılan 98 (% 53) erkek ve 87 (% 47) kadın 185 hasta çalışmaya dahil edildi. Ortalama yaş 12.6 (dağılım 3-56) idi. Toplam 64 hastada Actinomiçes varlığı gösterildi.Sonuç: Actinomyces türleri bademcik dokusu florasında fırsatçı enfeksiyona neden olan bakterilerdir. Tonsiller Aktinomikoz kolonizasyonu yetişkinlerde ve büyük çocuklarda daha yaygındır.