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  • Küçük Resim
    Öğe
    The effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model
    (2022) Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakaris, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak
    Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
  • [ X ]
    Öğe
    The Effects of Ferula elaeochytris on the Oxidant/Nitrosative Stress in Experimental Myoglobinuric Acute Renal Failure
    (Hacettepe Üniversitesi, 2025) Güngör, Meltem; Yalın, Serap; Ballı, Ebru; Bayrak, Gulsen; Yıldız, Fatma; Yıldırım, Metin; Pavlopoulou, Athanasia
    Free radicals and nitric oxide play an important role in the pathogenesis of Myoglobinuric Acute Renal Failure (mARF). Herein, we aimed to investigate the effects of Ferula elaeochytris on the oxidative-antioxidant system and nitrosative stress in experimental mARF. In our study, 56 Sprague-Dawley rats, equally divided in seven groups, were used as model organisms of experimentally induced mARF. A disease model of mARF was established with 50% glycerol in all groups except one. Moreover, 40 mg/kg and 80 mg/kg of F. elaeochytris root extract were administered intragastrically before and after model creation. The following were investgated in the kidney tissue: serum urea nitrogen, urea, creatinine, sodium and potassium levels of rats in all groups; urinary urea and creatinine levels; MDA, SOD, GPx, CAT, NO and nitrotyrosine parameters. In addition, histological changes in the kidney were recorder with electron microscopy. Significant changes were observed in the CAT, GPx and MDA values of all groups compared to the control group. Electron microscopy observations also supported these findings. Herein, we provide evidence regarding the limited protective and curative effects of Ferula elaeochytris on mARF through reduction of the oxidant/nitrosative stress.