Yazar "Ergun, Mehmet Ali" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • [ X ]
    Öğe
    ASSOCIATION BETWEEN MCT1 GENE POLYMORPHISM (rs1049434) WITH THE ATHLETIC PERFORMANCE OF ELITE TRACK AND FIELD ATHLETES
    (2023) Bulğay, Celal; Zorba, Erdal; Bayraktar, Işık; Kazan, Hasan; Ulucan, Korkut; Ergun, Mehmet Ali
    Monocarboxylate transporter 1 (MCT1; SLC16A1) is a proton-dependent cotransporter/exchanger, located on the apical membrane of cells. MCT1 is able to transport several monocarboxylates including lactate, pyruvate and acetate, which makes this protein critical in terms of the athletic performances. The rs1049434 polymorphism in the MCT1gene was frequently associated with the performance of the athletes in different populations. The present study aims to decipher any possible association of the rs1049434 polymorphism with the personal best of elite track and field athletes. A total of sixty elite athletes (31 sprint/power and 29 endurance) and twenty control/sedentary with the ages of 18-35 voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the personal best (PB) of the athletes. Whole exome sequencing (WES) was performed by the genomic DNA isolated from blood of the participants. Sport type, sex and PB were chosen as the parameters to compare within and between the groups by logistic regression models. The sex was not the criterion that was significantly different between or within the groups. Although PB scores were not significant within the sprint/power group, it was significant within the endurance group by the codominant (p=0.044), dominant (p=0.016) and over-dominant (p=0.048) models. The rs1049434 polymorphism in the MCT1 gene may be linked to the PB of the endurance athletes. However, other genetic alterations should be regarded to conclude the effect of this polymorphism. The multi-factorial genetic background that could associate with the athletic performance is still under investigation in our research group. Nevertheless, further studies with more participants are needed.
  • [ X ]
    Öğe
    Association of SOD2 Polymorphism (Rs4880) and Competitive Performance in Track and Field Athletes
    (2023) Kazan, Hasan; Bulğay, Celal; Zorba, Erdal; Bayraktar, Işık; Cerıt, Mesut; Ergun, Mehmet Ali
    The rs4880 polymorphism in the SOD2 gene has frequently been associated with the athletic performance of the athletes in different populations. However, there were not any studies in the Turkish elite athletes. Thus, the aim of the study is to evaluate the impacts of SOD2 rs4880 polymorphism on competitive performance of Turkish elite athletes. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 controls with the ages of 18-35 voluntarily participated in the study. World Athletics (WA) score table was used to determine the performance levels of the competitive performance/personal best (PB) of the athletes. Whole exome sequencing (WES) was performed by the genomic DNA isolated from peripheral blood of the participants. Sport type, sex and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. There were not any significances between the genotype and allele frequencies. Finally, there were not any associations between competitive performance and genotype frequencies within the sprint/power athletes while competitive performance was significantly (p=0.049) correlated with rs4880 polymorphism according to the over-dominant model within the endurance athletes. The rs4880 polymorphism in the SOD2 gene may be linked to the competitive performance of the endurance athletes. Still, further studies with more participants and analyzing multiple factors are needed.
  • [ X ]
    Öğe
    Athletic performance, sports experience, and exercise addiction: an association study on ANKK1 gene polymorphism rs1800497
    (Frontiers Media Sa, 2023) Bayraktar, Isik; Cepicka, Ladislav; Barasinska, Magdalena; Kazan, Hasan Huseyin; Zorba, Erdal; Ergun, Mehmet Ali; Eken, Ozgur
    Introduction: Exercise addiction is a phenomenon being able to affecting the athletic performance. The gene, ANKK1 and the polymorphism NM_178510.2:c.2137G > A (rs1800497) has been linked to the exercise addiction. However, further studies on diverse populations and sport branches are needed to totally explore the possible association of this polymorphism with the athletic performance. Thus, the present study aims to decipher any possible relations of the rs1800497 polymorphism with the athletic performance/personal best (PB) and sport experience of elite athletes. Methods: Sixty volunteer elite athletes (31 sprint/power and 29 endurance) and 20 control/sedentary participated in the study. The polymorphism was genotyped using whole exome sequencing approach and PB were determined according to the International Association of Athletics Federations (IAAF) score. Results: Our results underlined that there were not any significance differences for both allele and genotype frequencies between the groups in terms of athletic performance, although the frequency of allele G was higher (p > 0.05). Nevertheless, sport experience significantly associated with the rs1800496 polymorphism (p < 0.05). Discussion: In conclusion, genotype G/G could be inferred to be linked to the higher sport experience and athletic performance. Still, further studies with higher number of participants are needed to conclude the association of this polymorphism with athletic parameters.
  • Küçük Resim
    Öğe
    Evaluation of Association between PPARGC1A Gene Polymorphism and Competitive Performance of Elite Athletes
    (2022) Bulğay, Celal; Zorba, Erdal; Akman, Onur; Bayraktarı, Işık; Kazan, Hasan Hüseyin; Ergun, Mehmet Ali; Ulucan, Korkut
    Limited number of researches exist on the relationship between PPARGC1A gene polymorphism (rs8192678) and affects the athletic performance. Thus, the present study aims to decipher any possible association of the rs8192678 polymorphism in the PPARGC1A gene with the competitive performances of Turkish elite track and field athletes. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/sedentary with the ages of 18-35 voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the personal best (PB) of the athletes. Whole exome sequencing (WES) was performed by the genomic DNA sample isolated from blood of the participants. The association between rs8192678 polymorphism and PB was examined by one-way analysis of covariance (ANCOVA) with the adjustment of sex and sport experience. According to the results, there were not any significant deviation between the wild-type (G/G), heterozygote (G/A) and homozygote (A/A) genotypes within and between the groups (p>0.05). Our results underlined that there were not any significances for association of rs8192678 polymorphism with PBs within the groups of the sprint/power and endurance athletes. However, it is recommended that similar studies be conducted with more participants to provide clearer information about the research.
  • Küçük Resim
    Öğe
    Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes’ Competitive Performance
    (2023) Bulgay, Celal; Bayraktar, Işık; Kazan, Hasan Hüseyin; Yıldırım, Damla Selin; Zorba, Erdal; Akman, Onur; Ergun, Mehmet Ali; Cerit, Mesut; Ulucan, Korkut; Eken, Özgür; Ceylan, Halil İbrahim; Badicu, Georgian
    The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes’ performance. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/ physically inactive, aged 18–35, voluntarily participated in the study. The International Association of Athletics Federations (IAAF) score scale was used to determine the performance levels of the athletes’ personal best (PB). Whole exome sequencing (WES) was performed by the genomic DNA isolated from the peripheral blood of the participants. Sports type, sex, and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. The results showed no statistically significant difference between the CC, TC, and TT genotypes within and between the groups (p > 0.05). Additionally, our results underlined that there were no statistically significant differences for the association of rs2228570 polymorphism with PBs within the groups of the (p > 0.05) athletes. The genetic profile in the selected gene was similar in elite endurance, sprint athletes, and in controls, suggesting that rs2228570 polymorphism does not determine competitive performance in the analyzed athlete cohort. © 2023 by the authors.
  • [ X ]
    Öğe
    Investigation of the ACTN3 Gene Polymorphism (rs1815739) and FMS Values in Young Runners: Cross-Sectional Research
    (2023) Bulğay, Celal; Bayraktar, Işık; Odemıs, Merıc; Yildirim, Damla Selin; Ergun, Mehmet Ali; Cerıt, Mesut; Ulucan, Korkut
    Objective: The present study aims to examine investigation the ?-actinin-3 (ACTN3) gene polymorphism (rs1815739) and functional movement screen (FMS) values in young runners competing at the national level. Material and Methods: Forty-five young runners (29 male 64.4%, 16 female 35.6%) competing at the national level in different clubs affiliated to the Turkish Athletic Federation and training regularly at least 5 days a week voluntarily participated in the study. The DNA isolation of oral swab samples was carried out using the spin column (MN Macherey-Nagel, Germany) method. The genotyping pro- cess was performed using the real-time polymerase chain reaction method. Results: The FMS test battery was used to determine the functional capacity. According to the findings obtained, it was determined that in the FMS evaluation of the female runners, the runners with the CC genotype had a significantly higher mean score compared to the runners with the CT genotype (p<0.033) while in the male runners, the runners with the CT genotype had a significantly higher mean score compared to the runners with the TT genotype (p<0.031). However, in the FMS evaluation of the overall runners, no significant difference was found (p>0.205). Conclusion: It is thought that the FMS test battery and the ACTN3 gene polymorphism, which is among the important variables responsible for non-impact injuries, can be effective in the level of muscle damage, the type of muscle injury, the prediction of injuries and reducing the risk factors that may cause injuries.