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Öğe Asemptomatik bireylerde yaş ve cinsiyete bağlı patellofemoral morfolojideki farklılıkların analizi: Manyetik rezonans görüntüleme çalışması(2019) Ergün, TarkanAmaç: Bu çalışmanın amacı manyetik rezonans görüntülerden yararlanarak asemptomatik bireylerde yaş ve cinsiyete bağlı patellofemoral morfolojideki farklılıkları ortaya koymaktır. Gereç ve Yöntem: 2018 Eylül–2018 Aralık tarihleri arası diz ağrısı bulunmayan 92 gönüllü birey prospektif olarak değerlendirildi. Olgular yaşlarına göre 3 grupta sınıflandırıldı: Grup I: 18–39 yaş (n=34 olgu); Grup II: 40–59 yaş (n=32 olgu) ve Grup III: 60 yaş ve üzeri (n=26 olgu). Tüm bireylerde statik patellofemoral yapıyı gösteren patellar morfoloji (patella medial ve lateral faset uzunluk oranı ve interfaset açısı), troklear geometri (troklear oluk açısı, troklear derinlik, troklear faset asimetri, lateral troklear eğim açısı ve patellar translasyon) ve patellar yükseklik (insall salvati indeksi) ile dinamik patellofemoral anatomiyi gösteren tibial tüberkül-troklear oluk (TT–TO) mesafesi ölçüldü. Bulgular: Her iki cinsiyet arasında troklear oluk açısı, troklear derinlik, troklear faset asimetri, patellar translasyon, Insall Salvati indeksi, patella medial/lateral faset oranı ve TT–TO mesafesinde anlamlı farklılık vardı (P değerleri 0.045, 0.001, 0.001, 0.006, 0.005, 0.001 ve 0.032, sırasıyla, Bağımsız örneklem t-testi). Olguların yaşı arttıkça trohlear oluk açısı (P=0.003) ve Insall Salvati indeksinde (P=0.017) pozitif yönlü, troklear derinlik ölçümünde (P=0.026) ters yönlü farklılık bulundu. Sonuç: Asemptomatik bireylerde patellofemoral morfolojide yaş ve cinsiyete bağlı belirgin farklılıklar bulunur. Kadınlar ve daha ileri yaştaki bireyler patellofemoral dizilim bozukluğu gelişimine daha eğilimli diz yapısına sahiptir.Öğe Perforation of terminal ileum by a toothpick(Ma Healthcare Ltd, 2020) Özen, Özkan; Torun, Ebru; Yüksel, Yavuz; Ergün, Tarkan; Başaran, Ismail[No abstract available]Öğe Recurrent stump appendicitis(W.B. Saunders, 2020) Yüksel, Yavuz; Ergün, Tarkan; Torun, Ebru; Özen, ÖzkanAcute appendicitis is one of the most common reasons for abdominal surgery. Stump appendicitis, one of the rare complications of appendicitis surgery, is an inflammation that develops in the remaining part of the appendix following surgery and occurs at a rate of 1/50.000 in cases with appendectomy. Although patients manifest the same findings as those with acute appendicitis on physical examination and laboratory tests, the history of previous appendectomy may cause delays in diagnosis. Complications such as perforation and peritonitis can develop if an early diagnosis cannot be made. In this article, we present the first case of recurrent stump appendicitis reported in the literature as far as we are aware. © 2020 Elsevier Inc.Öğe Relationship between cervical posterior subcutaneous fat tissue thickness and the presence and degree of cervical intervertebral disc degeneration(2022) Yüksel, Yavuz; Ergün, Tarkan; Torun, EbruObjective: This study aimed to investigate the relationship between cervical region subcutaneous fat tissue thickness and the presence and level of cervical intervertebral disc degeneration (IVDD). Methods: Magnetic resonance imaging examinations of patients referred to our clinic for the investigation of neck pain were evaluated retrospectively. A total of 300 women aged 30–40 years were included in the study. The presence and level of IVDD were evaluated for each patient. The cervical subcutaneous fat tissue thickness was also measured. Results: IVDD was determined as Grade 1 for 88 patients (29.3%), Grade 2 for 56 patients (18.6%), Grade 3 for 82 patients (27.3%), Grade 4 for 60 patients (20%), and Grade 5 for 14 patients (4.6%). Subcutaneous fat tissue thickness was higher in patients with cervical disc degeneration (mean: 6.28±0.19mm) than in those without cervical disc degeneration (mean: 5.33±0.18mm) (P = .001). There was a positive correlation between the degree of cervical disc degeneration and subcutaneous fat tissue thickness ( = 0.001, r = 0.245). Conclusion: An increase in the cervical fat tissue thickness is a predisposing factor for the development of degeneration of the intervertebral disc. There is a close relationship between subcutaneous fat tissue thickness and the degree of degeneration. Abbreviations: BMI = body mass index, IL-1 = interleukin-1, IVDD = intervertebral disc degeneration, MRI = magnetic resonance imaging, TNF = tumor necrosis factor, WI = weighted images.Öğe The relationship between quadriceps fat pad syndrome and patellofemoral morphology: a case-control study(2021) Yüksel, Yavuz; Ergün, Tarkan; Torun, Ebru; Ünal, Melih; Sonnow, Lena; Köse, ÖzkanBackground The purpose of this prospective case-control study is to investigate the relationship between quadriceps fat pad syndrome (QFPS) and patellofemoral morphology. Materials and methods Twenty-two patients with QFPS and 22 age- and gender-matched healthy volunteers were included. The diagnosis of QFPS was supported both clinically and radiologically. On magnetic resonance imaging (MRI), patellofemoral morphology was evaluated with 13 radiological measurements including trochlear sulcus angle, trochlear sulcus depth, trochlear facet asymmetry, trochlear condyle asymmetry, lateral trochlear inclination angle, patellar translation, tibial tubercle-trochlear groove (TT-TG) distance, Insall-Salvati ratio, patellotrochlear index, patellar tilt, the ratio between lateral and medial facet lengths, interfacet angle, and quadriceps tendon thickness. The mean of measurements was compared between groups using the Mann-Whitney U test. Results There were 22 patients (12 male, 10 female) with mean age of 30.81 +/- 1.41 (range 19-38) years in group I and 22 patients (12 male, 10 female) with mean age of 31.13 +/- 1.31 (range 19-39) years in group II. The mean age and the gender distribution were statistically similar between groups (p = 0.845, p = 1, respectively). All measured values except for patellar tilt (p = 0.038) and TT-TG distance (p = 0.004) were similar (p > 0.05 for the other variables). However, all of the measured variables were within the normal range. Conclusions QFPS may not be associated with anatomical variations of the patellofemoral joint. Further studies are required to understand the etiology and risk factors.Öğe Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder(Churchill Livingstone, 2021) Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Öktem, Ece Özdemir; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfi; Hanoğlu, Lütfi; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, BurakAim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on multiple levels that goes beyond their conventional effects on neurotransmitters. Method: The study was approved by the Local Ethics Committee of Istanbul Medipol University (10840098-604.01.01-E.65129) and followed the Helsinki Declaration principles. In our study, we have evaluated the effect of six weeks of treatment with antidepressants (escitalopram and duloxetine), and tested the underlying brain functional connectivity through a Graph analysis approach in a well-defined first-episode, drug-naive, and non-comorbid population with MDD. Results: Beyond indicating that there was a significant correlation between the antidepressant response and topological characteristics of the brain, our results suggested that global rather than regional network alterations may be implicated in the antidepressant effect. Conclusion: Despite the small-sample size and non-controlled study design, our study provides important and relevant clinical data regarding the underlying mechanisms of the antidepressants on topological dynamics in the human brain. © 2020 Elsevier Ltd
