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    Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome
    (Walter De Gruyter Gmbh, 2021) Kucuksayan, Ertan; Ozben, Serkan; Tuac, Selma Topaloglu; Koseoglu, Mesrure; Erel, Ozcan; Neselioglu, Salim; Ozben, Tomris
    Objectives: Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods: A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results: Plasma total (401 +/- 27 mu mol/L) and native thiol (354 +/- 30 mu mol/L) levels were significantly lower, but disulphide level (24 +/- 6 itmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 +/- 36, 424 +/- 37, 15 +/- 5 mu mol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRL SSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions: Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.
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    Role of Oxidative Stress and Inflammatory Biomarkers in COVID-19 Pneumonia
    (2024) Ikıtımur, Hande; Kolbas, İlker; Cengiz, Mahir; Yavuzer, Serap; Yüksel, Bilge Özgür; Hanikoglu, Ferhat; Erel, Ozcan
    Introduction: SARS-CoV-2 causes severe lung damage and respiratory failure through oxidative stress. Biomarkers play a role in inflammation, in revealing the effects of oxidative stress, and in the regulation of treatment. The aim of our study was to reveal oxidative stress in COVID-19 patients by determining oxidative biomarkers and to examine the relationship of these parameters with lung involvement. Methods: The prospectively designed study included 45 patients hospitalized with the diagnosis of COVID-19 and 38 healthy controls. Total thiol, native thiol, disulfide, myeloperoxidase, ischaemia-modified albumin, and acute phase reactant levels to determine oxidative stress and inflammation were compared between the groups. Thorax tomography scoring was performed to determine the severity of pneumonia. The association of oxidative biomarkers with length of hospital stay and radiological score was evaluated. Results: We found that native thiol and total thiol levels decreased, and disulfide and myeloperoxidase levels increased in COVID-19 patients compared to the control group. A negative correlation was found between the duration of hospitalization and native thiol and total thiol levels (r=-0.312, p=0.043; r=-0.309, p=0.049). Native thiol and total thiol were negatively correlated with lung involvement on thorax tomography (r=-0.450, p=0.002; r=-0.436, p=0.003). MPO level was positively correlated with the duration of hospitalization (r=0.317, p=0.034). Discussion and Conclusion: These oxidative/inflammatory parameters play an important role in the lung involvement and disease monitoring of COVID-19 patients and can be used in the management of patients.