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Öğe Is thiol/disulphide homeostasis reliable as an additional serum marker to PSA in the diagnosis of prostate cancer?(Alanya Alaaddin Keykubat Üniversitesi, 2019) Topaktaş, Ramazan; Ürkmez, Ahmet; Kutluhan, Musab Ali; Akkoç, Ali; Özsoy, Emrah; Erel, ÖzcanAim: We aimed to investigate thiol/disulphide homeostasis as an additional serum marker to prostate specific antigen (PSA) in the diagnosis of prostate cancer. Patients and Methods: Prospective study was conducted among 174 patients with PSA levels of 2.5–20 ng/mL without suspicion of malignancy in rectal examination and who underwent prostate needle biopsy. A total of 75 patients were included in our study after exclusion criteria. Serum PSA, thiol, and disulphide levels of the patients were recorded prior to biopsy. In this study, 25 patients with pathology results indicating prostate cancer, 25 randomly selected patients with pathology results indicating chronic prostatitis, and 25 randomly selected patients with pathology results indicating benign prostate hyperplasia (BPH) were included. Results: Total and native thiol levels were higher in prostate cancer group than in BPH and chronic prostatitis groups; however, no statistically significant difference was observed (p> 0.05). When prostate cancer sub-groups were investigated, total and native thiol levels were noted to be higher in patients with a Gleason score of 7, 8, and 9 than in those with a Gleason score of 6; however, no statistically significant difference was observed (p> 0.05). Conclusions: Thiol levels were higher in prostate cancer group than in benign disease (BPH and chronic prostatitis) groups; these levels were also higher in group with high Gleason scores (Gleason 7, 8, or 9) than in group with a low Gleason score (Gleason 6); however, these differences were not statistically significant.Öğe Plasma thiol/disulphide homeostasis changes in patients with relapsing-remitting multiple sclerosis(2021) Özben, Serkan; Küçüksayan, Ertan; Köseoğlu, Mesrure; Erel, Özcan; Neşelioğlu, Salim; Özben, TomrisBackground: Multiple sclerosis (MS) is a neuroinflammatory disease and inflammation and oxidative stress play important roles in its pathology. Thiol/disulphide homeostasis (TDH) is a special oxidative stress biomarker that has been found to be affected in several disorders including MS. There is no study demonstrating the effects of attack status of the relapsing-remitting multiple sclerosis (RRMS) patients on TDH levels. Our aim was to determine TDH levels in three different periods of RRMS patients and healthy individuals. Methods: The study was carried out in 29 patients with RRMS without a prior attack in the last twelve months (MS Control), 21 RRMS patients having a clinical acute attack within the last week (MS relapse), 12 of 21 MS relapse patients one month after the onset of attack and following 1000 mg methylprednisolone for 7 days (MS Remission) and 30 age- and sex-matched healthy individuals. TDH status was determined using an automated spectrophotometric analysis method. TDH levels in all patient groups and control subjects were compared with each other. Results: The lowest native thiol, total thiol levels and native thiol/total thiol ratio were found in the MS relapse patients in comparison to the MS control, MS remission groups and healthy controls. In contrast, disulphide levels, disulphide/native thiol and disulphide/total thiol ratios were highest in the MS relapse group compared to the other patient groups and healthy subjects. Conclusion: Our findings indicate that increased oxidative stress in RRMS patients is reflected with decreased native and total thiol and increased disulphide levels. Since the formation of disulphide bonds is reversible, the progression of RRMS involving abnormal TDH may be controlled, converting disulphides to thiols. So, we suggest determining the dynamic TDH status as a novel and special biomarker in the diagnosis and prognosis of the RRMS patients. What’s known • Multiple sclerosis (MS) is a neuroinflammatory disease and inflammation and oxidative stress play important roles in its pathology. • Like other inflammatory diseases, oxidative stress is associated with MS playing an important role in the pathogenesis of MS. What’s new • Our study provides original data on dynamic Thiol/disulphide homeostasis (TDH) status in the relapsing-remitting multiple sclerosis (RRMS) patients at three different periods of the disease and examines whether plasma TDH can be used as a special oxidative stress biomarker in the diagnosis and follow-up of the RRMS patients and their response to the therapyÖğe Relationship of Biomarkers During Antegrade Cerebral Perfusion with Visceral Oxidative Stress and Neurological Outcomes(Alanya Alaaddin Keykubat Üniversitesi, 2025) Sungur, Elif Coşkun; Benli, Emre Demir; Enver, Levent; Özbek, Hamdi Mehmet; Erel, Özcan; Sarıtaş, AhmetAim: Antegrade selective cerebral perfusion (ASCP) is the standard brain preservation perfusion technique used in aortic surgery. We aimed to assess the relationship between visceral ischemia and neurological outcomes in the postoperative period by measuring oxidative stress blood biomarkers in blood samples taken from the descending aorta during antegrade selective cerebral perfusion. Patients and Methods: In this prospective observational and single-center study 54 patients were included. Group 1 (ASCP?20min) included the patients with ASCP times less than or equal to 20 minutes, and Group 2 (ASCP>20min) included the patients with ASCP times over 20 minutes. Blood samples were collected from the descending aorta and systemic blood to assess oxidative stress for all biomarkers at the end of ASCP. Blood samples were collected for other metabolic parameters in the preoperative period and postoperative day 0 (6th hour). Results: The PH and lactate levels in descending aorta and postoperative AST levels in Group 2 were statistically different in Group 1 (p < 0.001, p=0.004, p=0.012). There were statistical differences in descending aorta disulfide levels data between the groups. The ICU stay time, and the prolonged mechanical ventilator support were significantly different between the groups. Conclusion: The findings showed that parameters reflecting oxidative stress were significantly impacted by antegrade selective cerebral perfusion time, whereas new oxidative stress parameter levels were not affected. We consider the short-term antegrade selective cerebral perfusion time in the present study to be one of the main reasons for exposure to oxidative stress.Öğe The Effect of Regularly Performed Oderate-Intensity Exercise Program on Thiol/Disulfide Homeostasis, and Ischemia-Modified Albumin(2022) Pala, Mukaddes; Altan, Mehmet; Hanikoğlu, Ferahat; Neşelioğlu, Salim; Erel, Özcan; Metin, GökhanAim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels. Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method. Results: In the EG, total thiol levels were significantly higher compared to the CG (p<0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p<0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant. Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress.
