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    Öğe
    Diyaliz hastalarında etiyolojik farklılıkklar ve sigara içiciliği dikkate alınarak Hastaların bağımlılık düzeyi ve sosyal eğilimleri
    (Alanya Alaaddin Keykubat Üniversitesi, 2017) Çetin, Adil; Özdemir, Merve Betül; Arslan, İsmail; Tekin, Oğuz; Duranay, Murat
    Amaç: Diyaliz tedavisi gören kişilerin sigara bağımlılığıile sosyal eğilimleri arasında bir ilişki olup olmadığını araştırmayı amaçladık. Yöntem: Çalışmaya Ankara Eğitim ve Araştırma HastanesiNefroloji kliniğinde tedavi görmekte olan 106 hasta alındı. Çalışmaya alınan olgularyaş, cinsiyet, eğitim durumu, yerleşim yeri, ekonomik durum, sigara alışkanlıklarıve sosyal eğilimleri açısından değerlendirildi. Bulgular: Sigara bağımlılığı üzerinde cinsiyet, gelir durumu, Fatih Sosyal Eğilimler Ölçeğinin,sosyal uyum ve maddeden kaçınma skorlarının etkili olduğu görüldü.Sonuç: Çalışmamızda diyaliz hastalarında sigara içme durumuve riskleri ortaya konmuştur.
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    Öğe
    Post-Earthquake Realities: A Study on the Challenges of Relocated Hemodialysis Patients Following the Kahramanmaras Earthquake
    (Aves, 2025) Tugcu, Murat; Keles, Mustafa; Duranay, Murat; Huddam, Bulent; Yazici, Raziye; Ayar, Yavuz; Guzel, Fatma Betul
    On February 2023 T & uuml;rkiye experienced siniicant rtas ri.Background: In February 2023, T & uuml;rkiye experienced 2 significant earthquakes, measuring 7 .4 and 7.3 on the Richter scale and impacting 11 provinces. This study was performed to investigate the experiences of patients undergoing hemodialysis ftreatment in earthquake-affected areas who were relocated to alternative centers, with a focus on assessing the medical tchallenges that emerged thereafter. Methods: This study included 181 hemodialysis patients (71 females, 110 males) from 11 earthquake-affected provinces fwho were transferred to different dialysis centers because of infrastructure and superstructure damage at their original treatment facilities. Results: The predominant reason for relocation was damage to personal residences, reported by 77.4% of patients. Notably, 59.4% resumed hemodialysis with a delay of at least 1 day. Emergency complications were observed in 24.6% of patients, with hypervolemia (11.7%) being the most common. At the time of reporting, 23.1% of patients continued treatment at the relocated centers, while 78.8% expressed intent to return to their original facilities. Importantly, only 1 patient was reported to have died during the study period, highlighting the overall resilience of this population. Conclusion: Hemodialysis patients are particularly vulnerable to the impacts of earthquake-related disruptions. Dialysis centers in high-risk regions must adhere to construction standards that ensure operational resilience. Additionally, prioritizing the transfer and medical coordination of hemodialysis patients during disasters is essential to maintaining continuity of care and minimizing health risks.
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    Öğe
    Serum soluble Fas-ligand levels and flow-mediated vasodilation in patients undergoing peritoneal dialysis
    (2022) Huddam, Bülent; Azak, Alper; Karakuş, Volkan; Alp, Alper; Genek, Dilek Gibyeli; Koçak, Meral Gülay Kadıoğlu; Dere, Yelda; Soysal, Dilek Ersil; Duranay, Murat
    Flow-mediated vasodilation (FMD) has been demonstrated to be a useful, non-invasive tool for the detection ofendothelialdysfunction in atherosclerotic cardiovascular disease, the leading cause of mortality in end-stage kidney disease. The Fas/Fas ligand system of apoptosis resulting from activation of the caspase cascade- contributes to the pathophysiology of atherosclerosis. This ‘apoptotic’ system plays a central role in immune homeostasis. Vascular endothelial cells and inflammatory cells are the main resources of the Fas ligand. In this study, we aimed to investigate the role of soluble Fas ligand (sFasL) as a marker of FMD in peritoneal dialysis (PD) patients. Methods. A total of 43 patients undergoing maintenance PD and 40 healthy donors were enrolled in this cross-sectional observational study. Demographics, anthropometric measurements and clinical examinations were obtained. Endothelial function was evaluated by FMD of the brachial artery with high-resolution ultrasonography. Serum sFasL concentrations were measured with an enzyme-linked immunosorbent assay kit. Results. The enrolled partisipants were devited on 2 groups: PD patients who had been treated at least 12 weeks (group 1; mean age 41±14 years, M/F: 22/21) and gender matched 40 healthy controls (group 2; mean age 50±12 years, M/F: 19/20). The forearm FMD and serum sFasL levels were significantly lower in PD patients (3.95±2.01 vs 8.83 ± 6.17; p<0.001 and 54 ± 24 vs 73 ± 30; p=0.001). Forearm FMD was correlated with sFasL (r=0.289; p=0.008), age, BMI and uric acid (r= 0,32; p=0.003, respectively), hemoglobin (r= 0,293; p=0.007), calcium (r= 0,26; p=0.016), phosphate (r=- 0,250; p=0.023), magnesium (r= 0,255; p=0.020), 24 h SBP (r=- 0,257; p=0.019), creatinine and iPTH (r=- 0.50 and r=- 0,45; p[removed]